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Query BTE/Translator for all edges in DrugMechDB #181

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andrewsu opened this issue May 17, 2021 · 3 comments
Open

Query BTE/Translator for all edges in DrugMechDB #181

andrewsu opened this issue May 17, 2021 · 3 comments

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@andrewsu
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DrugMechDB (https://github.com/SuLab/DrugMechDB) is a database of drug mechanisms expressed as paths (or small graphs) through a knowledge graph. Let's take each edge in DrugMechDB, formulate a TRAPI query, and see if BTE can find it. Output will be some sort of report that describes what percentage of DrugMechDB edges are found, stratified by edge type.

Mike created an initial analysis in this repo https://github.com/SuLab/DMDB_Analysis/tree/main/1_code and in particular this notebook https://github.com/SuLab/DMDB_Analysis/blob/main/1_code/4_dmdb_bte_trapi_analysis.ipynb. Would be good to finish/finalize this.

@newgene
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newgene commented Jun 1, 2021

final result will depend on the fix of #185

@r76941156
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Final result will depend on the fix of #212

@andrewsu
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Rebooting this issue as a rotation project for Hanbing. Let's start with cell 20 in https://github.com/SuLab/DMDB_Analysis/blob/main/1_code/1_basic_dmdb_analysis.ipynb, which lists the common metapaths used in DrugMechDB. Starting with one of the more common metapaths, let's create a corresponding TRAPI query and see how many examples BTE (and/or other Translator tools) can retrieve.

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