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The somatic likelihoods model becomes very expensive when evaluated at every reference position. MT calling takes about 40 minutes in GVCF mode and 5 minutes without ref conf. Ideas for optimization include:
Reducing the convergence threshold for alleleFractionsPosterior method (my initial attempts here didn't make a big improvement)
Using a simplified likelihoods model for reference sites (similar to lnLikelihoodRatio used for active region determination)
Keeping LOD calculation from active region determination and only calculating it once
The text was updated successfully, but these errors were encountered:
The somatic likelihoods model becomes very expensive when evaluated at every reference position. MT calling takes about 40 minutes in GVCF mode and 5 minutes without ref conf. Ideas for optimization include:
alleleFractionsPosterior
method (my initial attempts here didn't make a big improvement)lnLikelihoodRatio
used for active region determination)The text was updated successfully, but these errors were encountered: