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Improve M2 ref conf compute performance #5561

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ldgauthier opened this issue Jan 4, 2019 · 0 comments · Fixed by #6457
Closed

Improve M2 ref conf compute performance #5561

ldgauthier opened this issue Jan 4, 2019 · 0 comments · Fixed by #6457
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@ldgauthier
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The somatic likelihoods model becomes very expensive when evaluated at every reference position. MT calling takes about 40 minutes in GVCF mode and 5 minutes without ref conf. Ideas for optimization include:

  • Reducing the convergence threshold for alleleFractionsPosterior method (my initial attempts here didn't make a big improvement)
  • Using a simplified likelihoods model for reference sites (similar to lnLikelihoodRatio used for active region determination)
  • Keeping LOD calculation from active region determination and only calculating it once
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