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Compute per channel percent strong #51

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niranjchandrasekaran opened this issue Aug 20, 2020 · 0 comments
Open

Compute per channel percent strong #51

niranjchandrasekaran opened this issue Aug 20, 2020 · 0 comments
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Experiment Discusses the rationale, results, and implications of an isolated experiment

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@niranjchandrasekaran
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While working on CPJUMP-Stain2, @shntnu and I observed that the proportion of compounds with a strong signal (percent strong metric) was similar if the analysis was performed with individual channels or across all channels. We wanted to find out if this behavior was seen in other datasets as well.

I chose one of the platemaps (H-BIOA-002-1) from BBBC022 and computed the channel-wise correlation values. Based on the results below, it looks like BBBC022 also behaves similarly.

BBBC022 channel-wise percent strong comparison

Click to expand!

3 BBBC022_H-BIOA-002-1_channels

BBBBC022 all channels percent strong

Click to expand!

3 BBBC022_H-BIOA-002-1_all

Performing this experiment with a larger dataset, such as LINCS, may help answer whether the above plots are technical artifacts or if this behavior is consistent across datasets.

@niranjchandrasekaran niranjchandrasekaran added the Experiment Discusses the rationale, results, and implications of an isolated experiment label Aug 20, 2020
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