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Can I use a specific gene set instead of the one in msigdbr? #11

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Phoenix12580 opened this issue Aug 11, 2024 · 1 comment
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enhancement New feature or request

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@Phoenix12580
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There are no parameter settings in runGSEA that would allow the user to perform gene set specific enrichment
What should I do if I want to enrich for a specified set of genes?
Thank you very much for your work, this is a very good tool!

@mass-a mass-a added the enhancement New feature or request label Aug 12, 2024
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mass-a commented Aug 12, 2024

Hello!
you are correct, currently runGSEA() only runs against MSigDB gene sets. I'll add the "enhancement" tag, we may implement custom gene sets in the future.
In fact this function is a simple wrapper to fgsea::fora() - perhaps in the meantime you should be able to edit the function to take a custom gene set?
Best
-massimo

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