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JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(109 seqs, 19 countries) #2538

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xz-keg opened this issue Mar 27, 2024 · 26 comments
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JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(109 seqs, 19 countries) #2538

xz-keg opened this issue Mar 27, 2024 · 26 comments

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@xz-keg
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xz-keg commented Mar 27, 2024

From branch 37 of sars-cov-2-variants/lineage-proposals#1253 and sars-cov-2-variants/lineage-proposals#1437

JN.1.18+S:F456V(T22928G)

GISAID query: G22599C, T22928G,C18894T, -6705,-C774T,-25658,-7789
No. of seqs: 5(USA 3 Singapore 1(from Saudi Arabia) Bangladesh 1)

First: EPI_ISL_18851598, Singapore from Saudi Arabia, 2024-1-12
Latest: EPI_ISL_19011021, USA, 2024-3-16

Usher places it in JN.1.16.1(R346T+F456L)+S:L456V (C22928G) . However that means position 22928 has to mutate from T->C->G in a short time, which is highly unlikely.
@AngieHinrichs @corneliusroemer

A better explanation shall be JN.1.18(R346T)+S:F456V(T22928G).

usher

image

@FedeGueli
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Thank you i noticed you havve excluded a couple more of convergent lineages are they among the ones already tracked?

@xz-keg
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xz-keg commented Mar 27, 2024

Thank you i noticed you havve excluded a couple more of convergent lineages are they among the ones already tracked?

No. They are singlets, one under JN.1.30.1 and another under an undesignated JN,1 branch

@FedeGueli
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Thank you i noticed you havve excluded a couple more of convergent lineages are they among the ones already tracked?

No. They are singlets, one under JN.1.30.1 and another under an undesignated JN,1 branch

thx just checked one is Singlet 6 of # 1089 while the other is unknown till you spotted i will add with credits to the tracking issue

@FedeGueli
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FedeGueli commented Mar 31, 2024

7 now two more GBW one from NZL

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(5 seqs, 4 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(7 seqs, 5 countries) Mar 31, 2024
@xz-keg
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xz-keg commented Apr 4, 2024

+1 Canada

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(7 seqs, 5 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(8 seqs, 6 countries) Apr 4, 2024
@xz-keg
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xz-keg commented Apr 8, 2024

14, India

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(8 seqs, 6 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(14 seqs, 7 countries) Apr 8, 2024
@xz-keg
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xz-keg commented Apr 12, 2024

20, Australia

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(14 seqs, 7 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(20 seqs, 8 countries) Apr 12, 2024
@FedeGueli
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21

@FedeGueli
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24 now (+4 with 2 from Qatar ) ping @corneliusroemer

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(20 seqs, 8 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(24 seqs, 9 countries) Apr 15, 2024
@FedeGueli
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31 now @corneliusroemer i suggest to designate this one.

@FedeGueli
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35 now with 4 new sequences coming from New Zealand, i suggest designating it.

@FedeGueli
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36 now last from England

@xz-keg
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xz-keg commented Apr 24, 2024

37, Japan, UK,

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(24 seqs, 9 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(37 seqs, 12 countries) Apr 24, 2024
@FedeGueli
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43 (+6 California,Illinois, NJ, Queensland, England )

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(37 seqs, 12 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(43 seqs, 12 countries) Apr 28, 2024
@FedeGueli
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53 +6 South Australia +3 Canada +1 Sweden

@FedeGueli
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59 (5 England +1 Japan)

@FedeGueli
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One of the UK sequences got S:S31Del and two additional spike mutations
Jn.1.18>S:f456V > C13620T > 11749G, T21610C, S:R190S (G22132T),S:E780A (A23901C), C27649T, ORF10:N36S(A29664G)
Query: del21653, C13620T

@xz-keg
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xz-keg commented May 5, 2024

65, South Korea, UAE,

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(43 seqs, 12 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(65 seqs, 14 countries) May 5, 2024
@FedeGueli
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83

@FedeGueli
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88, designation needed

@FedeGueli
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106 in 17 countries + airports samples that i didnt count in countries ,now
ping @corneliusroemer now also Australia and New Zealand

@xz-keg
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xz-keg commented May 18, 2024

109, Thailand, Peru, Germany, Norway, Brazil

@xz-keg xz-keg changed the title JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(65 seqs, 14 countries) JN.1.18+S:F456V misplaced as JN.1.16.1+S:L456V(109 seqs, 19 countries) May 18, 2024
@FedeGueli
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+1 Jap

@xz-keg
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xz-keg commented May 28, 2024

Designated JN.1.18.3

@FedeGueli
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Jn.1.18.3 via 978a25a

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