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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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<meta name="description" content="EBRAINS - Cellular Level
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title="OBJECTIVES" alt="OBJECTIVES">
OBJECTIVES
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href="#ouc" id="navbarDropdown" role="button"
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WORKFLOWS / USE CASES</a>
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<a class="dropdown-item" href="./online-use-cases.html"><span class="item-text">EXPLORE ALL</span></a>
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<!-- end of dropdown menu online use cases -->
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LIVE PAPERS
</a>
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<a class="dropdown-item" target="_blank" href="https://bspmonitors.cineca.it/hpc-monitor/#"><span class="item-text">HPC MONITOR</span></a>
</div>
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<a class="nav-link page-scroll" href="#whoWeAre"
title ="TEAM" alt="TEAM">
TEAM
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title="CONTACTS" alt="CONTACTS">
CONTACTS
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<p class="p-x-large">EBRAINS</p><!--<span id="js-rotating"></span></h1>-->
<p class="p-x-large">Cellular Level Simulation</p>
<h1>Interactive Workflows and Use Cases</h1>
<br>
<br>
<p class="p-heading p-x-large"><span id="js-rotating">Build, Reconstruct, Simulate</span>
<br>data-driven brain models</p>
<a class="btn-solid-lg page-scroll" href="#objectives">DISCOVER</a>
</div>
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<div class="section-title">OBJECTIVES</div>
<h2>
Reconstruct and simulate data-driven scaffold
models of brain and brain tissue
</h2>
<p>
In coordination with the other parts of the HBP,
we have four long-term objectives
<ul>
<li>
establish a generic strategy to reconstruct and simulate the multi-level organisation of the brain for different brain areas, whole brains and species;
</li>
<li>
use this strategy to build high-fidelity reconstructions, first of the mouse brain and ultimately, of the human brain;
</li>
<li>
support in silico experiments using the models;
</li>
<li>
support community-driven reconstructions and simulations, and comparisons between models based on different tools and approaches.
</li>
</ul>
</p>
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</span>
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<a href="./online-use-cases.html" target="_blank">
<h4 class="card-title">Workflows and Use Cases</h4>
</a>
<p>We provide tools and services that enable you to work through a number of pipelines; these are categorised by level of expertise and by their service maturity level.</p>
</div>
</div>
<!-- end of card -->
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<a href="https://wiki.ebrains.eu/" target="_blank">
<h4 class="card-title">Community driven</h4>
</a>
<p>Results, methods and code are shared and made public to boost collaborative scientific advancements</p>
</div>
</div>
<!-- end of card -->
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</span>
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<h4 class="card-title">Co-design</h4>
<p>A co-design loop between science and engineering ensures the required substantial technical and scientific innovations</p>
</div>
</div>
<!-- end of card -->
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<hr style="width:100%;">
<!-- Workflows and Use Cases -->
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<div class="text-container">
<div class="section-title">WORKFLOWS AND USE CASES</div>
<h2>Choose The Tools That Better Suit Your Needs</h2>
<p>Interactive Workflows and Use Cases are selected procedures
that guide the users through the resolution of
realistic scientific problems. A dedicated
<a href="https://humanbrainproject.github.io/hbp-sp6-guidebook/">Guidebook</a>
instructs the users on how to best exploit the
utilities offered by the Platform.
<br>
<ul class="list-unstyled li-space-lg">
<li class="media">
<i class="fas fa-square"></i>
<div class="media-body">Grouped by topic</div>
</li>
<li class="media">
<i class="fas fa-square"></i>
<div class="media-body">Accessible via interactive panels</div>
</li>
<li class="media">
<i class="fas fa-square"></i>
<div class="media-body">Implemented as either Web Applications or Python Jupyter Notebooks</div>
</li>
</ul>
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<div class="counter-value number-count" data-count="14">1</div>
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</div>
<div class="cell">
<div class="counter-value number-count" data-count="6">1</div>
<div class="counter-info">Jupyter<br>Notebooks</div>
</div>
<div class="cell">
<div class="counter-value number-count" data-count="8">1</div>
<div class="counter-info">Web<br>Applications</div>
</div>
</div>
<div class="text-container center-btn-cont">
<a class="text-center btn-solid-reg page-scroll"
href="./online-use-cases.html">EXPLORE</a>
</div> <!-- end of button-container -->
<!-- end of counter -->
</div> <!-- end of text-container -->
</div> <!-- end of col -->
</div> <!-- end of row -->
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<hr style="width:100%;">
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<div class="section-title">MONITORS</div>
<h2>
Visualize HPC systems available resources
</h2>
<p>
<ul>
<li>
The HPC Status Monitor allows a real-time check
of the availability status of the HPC systems
accessible from the platform and provides an
instant snapshot of the resource quotas
available to the user on each system
</li>
</ul>
</p>
</div> <!-- end of text-container -->
</div> <!-- end of col -->
<div class="col-lg-6 vertical-center" style="text-align: center">
<div style="margin:auto" class="image-container">
<a target="_blank" href="https://bspmonitors.cineca.it/hpc-monitor/">
<img style="width: 100% !important" class="" src="./static/images/monitor_hpc.svg" alt="alternative">
</a>
</div> <!-- end of image-container -->
</div> <!-- end of col -->
</div> <!-- end of row -->
</div> <!-- end of container -->
</div> <!-- end of basic-1 -->
<!-- end of monitors -->
<hr style="width:100%;">
<!-- Testimonials -->
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<div class="container">
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<div class="col-lg-12">
<div style="text-align:center; margin-bottom:10px"
class="section-title">LIVE PAPERS</div>
<h2>Live Papers</h2>
<p class="p-heading">
The "Live Papers" are highly interactive documents that
give you access to the resources presented in recently
published scientific articles related to the tools and
services available on the Platform
</div> <!-- end of col -->
</div> <!-- end of row -->
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<div class="testimonial-text">
An efficient analytical
reduction of detailed
nonlinear neuron models.
<br>
Nat. Commun.</div>
<div class="testimonial-author">Amsalem et al. 2020</div>
</div>
</div>
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Graph-theoretical Derivation
of Brain Structural
Connectivity.
<br>
Appl. Math. Comput. </div>
<div class="testimonial-author">Giacopelli et al. 2020</div>
</div>
</div>
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The microcircuits of
striatum in silico.
<br>
PNAS
</div>
<div class="testimonial-author">Hjorth et al. 2020</div>
</div>
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Computational modeling of
inhibitory transsynaptic
signaling in hippocampal
and cortical neurons
expressing intrabodies
against gephyrin.
<br>
Front. Cell. Neurosci.
</div>
<div class="testimonial-author">
Lupascu et al. 2020
</div>
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Circadian Modulation of
Neurons and Astrocytes
Controls Synaptic Plasticity
in Hippocampal Area CA1.
<br>
Cell. Rep.
</div>
<div class="testimonial-author">McCauley et al. 2020</div>
</div>
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Parameter tuning
differentiates granule cell
subtypes enriching
transmission properties
at the cerebellum input
stage.
<br>
Commun. Biol.
</div>
<div class="testimonial-author">Masoli et al. 2020</div>
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Copyright © 2020 Human Brain Project. All Rights Reserved.
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This project is supported by the European Union
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