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INaK.em
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INaK.em
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@{
INaK_I = 71.0920500406155
INaK_gate = 0.5355938158215787
INaK_amp = {
"V" : 10.8,
"EMB" : 10.8,
"LAT" : 10.8,
"NEO" : 10.8,
"SAN" : 14.5,
"A" : 14.5,
}
}
System System(/CELL/MEMBRANE/INaK)
{
StepperID ODE;
Variable Variable( I )
{
Value @INaK_I;
}
Variable Variable( vgate )
{
Value 1.76804588672e-06;
}
Variable Variable( gate )
{
Value @INaK_gate;
}
Variable Variable( Couabain )
{
MolarConc 0.0;
}
Variable Variable( E1A )
{
Value 0.209952775275;
}
Variable Variable( E2A )
{
Value 0.532101004335;
}
Variable Variable( GX ){
Value @( NaK_ATPase[SimulationMode]);
}
Process INaKAssignmentProcess( I )
{
StepperID PSV;
Priority 20;
VariableReferenceList
[ Nai :../../CYTOPLASM:Na 0 ]
[ Ki :../../CYTOPLASM:K 0 ]
[ PKA :../../CYTOPLASM:PKA 0 ]
[ Vm :..:Vm 0 ]
[ vrtf :..:_vrtf 0 ]
[ T :/:T 0 ]
[ Nao :/:Na 0 ]
[ Ko :/:K 0 ]
[ R :/:R 0 ]
[ F :/:F 0 ]
[ ATP :../../CYTOPLASM:ATPtotal 0 ]
[ GX :.:GX 0 ]
[ Couabain :.:Couabain 0 ]
[ dy :.:vgate 1 ]
[ y :.:gate 0 ]
[ E1A :.:E1A 1 ]
[ E2A :.:E2A 1 ]
[ I :.:I 1 ]
[ Cm :..:Cm 0 ];
KmNai 4.05e-3; # control dissociation constant for intracellular Sodium (M)
KmKi 32.88e-3; # dissociation constant for intracellular Potassium (M)
nHNa 1.06; # Hill coefficient of Sodium
nHK 1.12; # Hill coefficient of Potassium
amplitudePKAf 1.0; # to modulate PKA effect
# PKA phosphorylation parameter
ratio 0.35;
KmPKA 0.0005e-3; # (M)
hill 5.0;
KmNao 69.8e-3; # dissociation constant for extracellular Sodium (M)
KmKo 0.258e-3; # dissociation constant for extracellular Potassium (M)
ramda -0.82; # relative depth of access channel
k2 0.04; # rate constant for the reaction E2Na->E1Na
k3 0.01; # rate constant for the reaction E1K->E2K
k4 0.165; # rate constant for the reaction E2K->E1K
KmATP 0.094e-3; # hydrolysis coefficient of ATP (M)
amplitude0 @(INaK_amp[SimulationMode]); # (pA/pF)
# amplitude0 10.8; # (pA/pF)
# amplitude0 1.43; # (pA/pF)
}
Process ZeroVariableAsFluxProcess( gate )
{
Priority 15;
VariableReferenceList
[ y :.:gate 1 ]
[ dy :.:vgate 0 ];
}
Process IonFluxProcess( j )
{
Priority 11;
VariableReferenceList
[ Ke :/:K -2 ]
[ Ki :../../CYTOPLASM:K 2 ]
[ Nae :/:Na 3 ]
[ Nai :../../CYTOPLASM:Na -3 ]
[ ATP :../../CYTOPLASM:ATPtotal -1 ]
[ ADP :../../CYTOPLASM:ADPtotal 1 ]
#[ Pi :../../CYTOPLASM:Pi 1 ]
[ i :.:I 0 ]
[ N_A :/:N_A 0 ]
[ F :/:F 0 ]
[ z :/:zNa 0 ];
}
@MembranePotential( 'I' )
@addToTotalCurrent( 'currentNa', 'I', 3 )
@addToTotalCurrent( 'currentK', 'I', -2 )
@addToTotalCurrent( 'current', 'I' )
}
@{'''
Author Yasuhiro Naito
Version 0.1 2008-11-27 06:26:40 +0900
<INaK name="INaK" initial_value="71.0920500406155"
className="org.simBio.bio.kuzumoto_et_al_2007.current.carrier.INaK">
<link name="Vm" initial_value="../Vm" units="mV" />
<link name="Cm" initial_value="../membrane capacitance" />
<link name="current" initial_value="../current" />
<link name="currentNa" initial_value="../currentNa" />
<link name="currentK" initial_value="../currentK" />
<link name="Vi" initial_value="../volume" />
<link name="Nai" initial_value="../Na" units="mM" />
<link name="Nao" initial_value="../../Na" units="mM" />
<link name="Ki" initial_value="../K" units="mM" />
<link name="Ko" initial_value="../../K" units="mM" />
<link name="ATP" initial_value="../ATPtotal" units="mM" />
<link name="ADP" initial_value="../ADPtotal" units="mM" />
<link name="Pi" initial_value="../Pi" units="mM" />
<link name="PKA" initial_value="../PKA" units="mM" />
<link name="R" initial_value="/Gas constant" />
<link name="T" initial_value="/absolute temperature" units="K" />
<link name="F" initial_value="/Faraday constant" units="Coulomb/mM" />
<variable name="gate" initial_value="0.5355938158215787" />
<parameter name="stoichiometryNa" initial_value="3.0" units="pA/mM" />
<parameter name="stoichiometryK" initial_value="-2.0" units="pA/mM" />
<parameter name="amplitude0" initial_value="10.8" units="pA/pF" />
<parameter name="Couabain" initial_value="0.0" units="mM" />
<parameter name="amplitude" initial_value="10.8" units="pA/pF" />
</INaK>
'''}