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ISRCA.em
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ISRCA.em
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@{
ISRCA_I = -49.37365888139317
ISRCA_gate = 0.02932301538170902
ISRCA_amp = {
"V" : 19.0,
"EMB" : 19.0,
"LAT" : 19.0,
"NEO" : 19.0,
"SAN" : 3.762,
"A" : 19.0,
}
}
System System(/CELL/CYTOPLASM/SRUP/ISRCA)
{
StepperID ODE;
Variable Variable( I )
{
Value @ISRCA_I;
}
Variable Variable( gate )
{
Value @ISRCA_gate;
}
Variable Variable( GX ){
Value @( SERCA[SimulationMode]);
}
Process ISRCAAssignmentProcess( I )
{
StepperID PSV;
Priority 16;
VariableReferenceList
[ Cao :..:Ca ] # Ca2+ concentration in SR (uptake site compartment)
[ Cai :../..:Ca ] # Ca2+ concentration in cytoplasm
[ PLBphos :..:PLBphos ]
[ dE :.:dE ]
[ y :.:gate ]
[ ATP :../..:ATPtotal ]
[ I :.:I 1]
[ SR_f :../..:SR_activity 0 ]
[ GX :.:GX ]
[ Cm :../../../MEMBRANE:Cm ];
KmCaSR 3.0e-3; # (M)
hill 2.0;
amplitudePKAf 1.0; # to modulate PKA effect
a -3.93e-4; # (mM) dimensionless?
b 6.85e-7; # (M)
kmcacp_minimum 1e-8; # (M)
KmATP 0.1e-3; # (M)
k1 0.01;
k3 1.0;
k4 0.01;
amplitude @(ISRCA_amp[SimulationMode]);
# amplitude 19.0;
# amplitude 0.0755681818181818;
# amplitude 4.29942857142857;
# amplitude 0.57;
}
# Variable Variable( dEA )
# {
# Value 0.0123040417866;
# }
Variable Variable( dE )
{
Value -1.55351689138e-05;
}
Process ZeroVariableAsFluxProcess( E )
{
Priority 12;
VariableReferenceList
[ y :.:gate 1 ]
[ dy :.:dE 0 ];
}
Process IonFluxProcess( j )
{
Priority 11;
VariableReferenceList
[ out :../..:CaTotal 2 ] # Ca2+ concentration in cytoplasm
[ in :..:Ca -2 ] # Ca2+ concentration in SR (uptake site compartment)
[ ATP :../..:ATPtotal 1 ]
[ ADP :../..:ADPtotal -1 ]
#[ Pi :../..:Pi -1 ]
[ i :.:I 0 ]
[ N_A :/:N_A 0 ]
[ F :/:F 0 ]
[ z :/:zCa 0 ];
@# stoichiometryCa = 2.0 がここに反映されている
}
}
@{'''
Author Hitomi I. SANO
Author Yasuhiro Naito
Version 0.2 2008-11-30 17:24:45 +0900
<ICaPump name="ISRCA" initial_value="-49.37365888139317"
className="org.simBio.bio.kuzumoto_et_al_2007.current.carrier.ICaPump">
<link name="Cm" initial_value="../../membrane capacitance" />
<link name="Vi" initial_value="../../volume" />
<link name="F" initial_value="/Faraday constant" />
<link name="Cai" initial_value="../../Ca" units="mM" />
<link name="Cao" initial_value="../Ca" units="mM" />
<link name="ATP" initial_value="../../ATPtotal" units="mM" />
<link name="ADP" initial_value="../../ADPtotal" units="mM" />
<link name="Pi" initial_value="../../Pi" units="mM" />
<link name="current" initial_value="/dummy" />
<link name="currentCa" initial_value="../currentCa" />
<link name="PLBphos" initial_value="../PLB/PLBphos" units="mM" />
<variable name="gate" initial_value="0.02932301538170902" />
<parameter name="amplitude" initial_value="19.0" />
<parameter name="stoichiometryCa" initial_value="2.0" units="pA/mM" />
<parameter name="KmCaSR" initial_value="3.0" units="mM" />
<parameter name="a" initial_value="-3.93E-4" units="mM" />
<parameter name="b" initial_value="6.85E-4" units="mM" />
<parameter name="hill" initial_value="2.0" />
</ICaPump>
<current name="currentCa" initial_value="11.903628470056404" units="pA">
<link name="in" initial_value="../Ca" units="mM" />
<link name="out" initial_value="../../CaTotal" units="mM" />
<link name="Vi" initial_value="../volume" />
<link name="Vo" initial_value="../../volume" />
<link name="F" initial_value="/Faraday constant" />
<parameter name="valence" initial_value="2.0" units="dimension_less" />
</current>
'''}