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ca3_hs.eml
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<?xml version="1.0" ?>
<eml>
<stepper class="FixedODE1Stepper" id="Default"/>
<system class="System" id="/">
<property name="StepperID">
<value>Default</value>
</property>
<variable class="Variable" id="SIZE">
<property name="Value">
<value>1.0</value>
</property>
</variable>
<variable class="Variable" id="F">
<property name="Value">
<value>96520</value>
</property>
</variable>
<variable class="Variable" id="R">
<property name="Value">
<value>8.3134</value>
</property>
</variable>
<variable class="Variable" id="PI">
<property name="Value">
<value>3.14</value>
</property>
</variable>
<variable class="Variable" id="celsius">
<property name="Value">
<value>30</value>
</property>
</variable>
<variable class="Variable" id="T">
<property name="Value">
<value>303.14</value>
</property>
</variable>
<variable class="Variable" id="Rm">
<property name="Value">
<value>60000</value>
</property>
</variable>
<variable class="Variable" id="cm">
<property name="Value">
<value>0.001</value>
</property>
</variable>
<variable class="Variable" id="Ra">
<property name="Value">
<value>0.02</value>
</property>
</variable>
<variable class="Variable" id="vrest">
<property name="Value">
<value>-65</value>
</property>
</variable>
<variable class="Variable" id="vinit">
<property name="Value">
<value>-65</value>
</property>
</variable>
<variable class="Variable" id="vk">
<property name="Value">
<value>-91</value>
</property>
</variable>
<variable class="Variable" id="vna">
<property name="Value">
<value>50</value>
</property>
</variable>
<variable class="Variable" id="cai_init">
<property name="Value">
<value>5.0e-5</value>
</property>
</variable>
<variable class="Variable" id="cao">
<property name="Value">
<value>2</value>
</property>
</variable>
<variable class="Variable" id="v">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="dt">
<property name="Value">
<value>1</value>
</property>
</variable>
<variable class="Variable" id="t">
<property name="Value">
<value>1</value>
</property>
</variable>
<variable class="Variable" id="gna11">
<property name="Value">
<value>2.0</value>
</property>
</variable>
<variable class="Variable" id="gcatbar">
<property name="Value">
<value>0.45</value>
</property>
</variable>
<variable class="Variable" id="gcat31">
<property name="Value">
<value>0.45</value>
</property>
</variable>
<variable class="Variable" id="gcat32">
<property name="Value">
<value>0.45</value>
</property>
</variable>
<variable class="Variable" id="gcat33">
<property name="Value">
<value>0.45</value>
</property>
</variable>
<variable class="Variable" id="gcatbar_C4565">
<property name="Value">
<value>0.72</value>
</property>
</variable>
<variable class="Variable" id="gcanbar">
<property name="Value">
<value>0.0025</value>
</property>
</variable>
<variable class="Variable" id="gcalbar">
<property name="Value">
<value>0.0025</value>
</property>
</variable>
<variable class="Variable" id="gkdr">
<property name="Value">
<value>0.08</value>
</property>
</variable>
<variable class="Variable" id="gka">
<property name="Value">
<value>0.0001</value>
</property>
</variable>
<variable class="Variable" id="gkm">
<property name="Value">
<value>0.00002</value>
</property>
</variable>
<variable class="Variable" id="gkc">
<property name="Value">
<value>0.00005</value>
</property>
</variable>
<variable class="Variable" id="gkahp">
<property name="Value">
<value>0.0000018</value>
</property>
</variable>
<variable class="Variable" id="gpas">
<property name="Value">
<value>1.66666666667e-05</value>
</property>
</variable>
<variable class="Variable" id="cai">
<property name="Value">
<value>5.0e-5</value>
</property>
</variable>
<variable class="Variable" id="ina">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ina11">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="icat">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="icat_alpha1G">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="icat_alpha1H">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="icat_alpha1I">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="iC4565">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ican">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ical">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ica">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ikdr">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ika">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ikm">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ikc">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ikahp">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ipas">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ion">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="current">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Ist">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MC3">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MC">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MO">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MI">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MIs">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MC2">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="IC3">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="IC2">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_MIs2">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="M_C3">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="M_C2">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="M_C">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="M_O">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="M_OP">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_OP">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="Na_O">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="OPs">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="M_IF">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ina11_wt">
<property name="Value">
<value>0.0</value>
</property>
</variable>
<variable class="Variable" id="ina11_mt">
<property name="Value">
<value>0.0</value>
</property>
</variable>
<variable class="Variable" id="mn">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="hn">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ml">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="nth">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="lth">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ntg">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ltg">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="nti">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="lti">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ntC4565">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="ltC4565">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="nkdr">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="lkdr">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="nka">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="lka">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="mkm">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="okc">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="wkahp">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="seg">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="area">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="diam">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="dx">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="g">
<property name="Value">
<value>0</value>
</property>
</variable>
<process class="ExpressionFluxProcess" id="cai">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>0.1*(-0.15*ica.Value+(-1.0*cai.Value)/5.0)</value>
</property>
<property name="VariableReferenceList">
<value>
<value>cai</value>
<value>:/:cai</value>
<value>1</value>
</value>
<value>
<value>ica</value>
<value>:/:ica</value>
<value>0</value>
</value>
</property>
</process>
<variable class="Variable" id="r3">
<property name="Value">
<value>15</value>
</property>
</variable>
<variable class="Variable" id="L3">
<property name="Value">
<value>25.5</value>
</property>
</variable>
<process class="ExpressionAssignmentProcess" id="diam">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>2.0*r3.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>diam</value>
<value>:/:diam</value>
<value>1</value>
</value>
<value>
<value>r3</value>
<value>:/:r3</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="dx">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>L3.Value/1.0</value>
</property>
<property name="VariableReferenceList">
<value>
<value>dx</value>
<value>:/:dx</value>
<value>1</value>
</value>
<value>
<value>L3</value>
<value>:/:L3</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="area">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>PI.Value*diam.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>area</value>
<value>:/:area</value>
<value>1</value>
</value>
<value>
<value>PI</value>
<value>:/:PI</value>
<value>0</value>
</value>
<value>
<value>diam</value>
<value>:/:diam</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="g">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>4.0 * Ra.Value*dx.Value/(PI.Value*diam.Value*diam.Value)</value>
</property>
<property name="VariableReferenceList">
<value>
<value>g</value>
<value>:/:g</value>
<value>1</value>
</value>
<value>
<value>Ra</value>
<value>:/:Ra</value>
<value>0</value>
</value>
<value>
<value>dx</value>
<value>:/:dx</value>
<value>0</value>
</value>
<value>
<value>PI</value>
<value>:/:PI</value>
<value>0</value>
</value>
<value>
<value>diam</value>
<value>:/:diam</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="icat">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>icat_alpha1G.Value+icat_alpha1H.Value+icat_alpha1I.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>icat</value>
<value>:/:icat</value>
<value>1</value>
</value>
<value>
<value>icat_alpha1G</value>
<value>:/:icat_alpha1G</value>
<value>0</value>
</value>
<value>
<value>icat_alpha1H</value>
<value>:/:icat_alpha1H</value>
<value>0</value>
</value>
<value>
<value>icat_alpha1I</value>
<value>:/:icat_alpha1I</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="ica">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>icat.Value + ican.Value + ical.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>ica</value>
<value>:/:ica</value>
<value>1</value>
</value>
<value>
<value>icat</value>
<value>:/:icat</value>
<value>0</value>
</value>
<value>
<value>ican</value>
<value>:/:ican</value>
<value>0</value>
</value>
<value>
<value>ical</value>
<value>:/:ical</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="ion">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>ina11.Value+icat.Value+ican.Value+ical.Value+ikdr.Value+ika.Value+ikm.Value+ikc.Value+ikahp.Value+ipas.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>ion</value>
<value>:/:ion</value>
<value>1</value>
</value>
<value>
<value>ina11</value>
<value>:/:ina11</value>
<value>0</value>
</value>
<value>
<value>icat</value>
<value>:/:icat</value>
<value>0</value>
</value>
<value>
<value>ican</value>
<value>:/:ican</value>
<value>0</value>
</value>
<value>
<value>ical</value>
<value>:/:ical</value>
<value>0</value>
</value>
<value>
<value>ikdr</value>
<value>:/:ikdr</value>
<value>0</value>
</value>
<value>
<value>ika</value>
<value>:/:ika</value>
<value>0</value>
</value>
<value>
<value>ikm</value>
<value>:/:ikm</value>
<value>0</value>
</value>
<value>
<value>ikc</value>
<value>:/:ikc</value>
<value>0</value>
</value>
<value>
<value>ikahp</value>
<value>:/:ikahp</value>
<value>0</value>
</value>
<value>
<value>ipas</value>
<value>:/:ipas</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="current">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>ion.Value+Ist.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>current</value>
<value>:/:current</value>
<value>1</value>
</value>
<value>
<value>ion</value>
<value>:/:ion</value>
<value>0</value>
</value>
<value>
<value>Ist</value>
<value>:/:Ist</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionFluxProcess" id="v">
<property name="Priority">
<value>-5</value>
</property>
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>-1.0*current.Value/cm.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>v</value>
<value>:/:v</value>
<value>1</value>
</value>
<value>
<value>current</value>
<value>:/:current</value>
<value>0</value>
</value>
<value>
<value>cm</value>
<value>:/:cm</value>
<value>0</value>
</value>
</property>
</process>
<variable class="Variable" id="cat_human_alpha1G_n_inf">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_l_inf">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_tau_n">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_tau_l">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_vv">
<property name="Value">
<value>0</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_gbar">
<property name="Value">
<value>0.008</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_vhalfn">
<property name="Value">
<value>-49.3</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_vhalfl">
<property name="Value">
<value>-74.2</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_kn">
<property name="Value">
<value>4.6</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_kl">
<property name="Value">
<value>-5.5</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_q10">
<property name="Value">
<value>2.3</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_qt">
<property name="Value">
<value>1.0</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_pcabar">
<property name="Value">
<value>0.0001</value>
</property>
</variable>
<variable class="Variable" id="cat_human_alpha1G_z">
<property name="Value">
<value>2</value>
</property>
</variable>
<process class="ExpressionAssignmentProcess" id="cat_human_alpha1G_vv">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>lt(t.Value,dt.Value)*(-65)+geq(t.Value,dt.Value)*cat_human_alpha1G_vv.Value</value>
</property>
<property name="VariableReferenceList">
<value>
<value>cat_human_alpha1G_vv</value>
<value>:/:cat_human_alpha1G_vv</value>
<value>1</value>
</value>
<value>
<value>t</value>
<value>:/:t</value>
<value>0</value>
</value>
<value>
<value>dt</value>
<value>:/:dt</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="cat_human_alpha1G_n_inf">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>1/(1+exp(-(v.Value-cat_human_alpha1G_vhalfn.Value)/cat_human_alpha1G_kn.Value))</value>
</property>
<property name="VariableReferenceList">
<value>
<value>cat_human_alpha1G_n_inf</value>
<value>:/:cat_human_alpha1G_n_inf</value>
<value>1</value>
</value>
<value>
<value>v</value>
<value>:/:v</value>
<value>0</value>
</value>
<value>
<value>cat_human_alpha1G_vhalfn</value>
<value>:/:cat_human_alpha1G_vhalfn</value>
<value>0</value>
</value>
<value>
<value>cat_human_alpha1G_kn</value>
<value>:/:cat_human_alpha1G_kn</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="cat_human_alpha1G_l_inf">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>1/(1+exp(-(v.Value-cat_human_alpha1G_vhalfl.Value)/cat_human_alpha1G_kl.Value))</value>
</property>
<property name="VariableReferenceList">
<value>
<value>cat_human_alpha1G_l_inf</value>
<value>:/:cat_human_alpha1G_l_inf</value>
<value>1</value>
</value>
<value>
<value>v</value>
<value>:/:v</value>
<value>0</value>
</value>
<value>
<value>cat_human_alpha1G_vhalfl</value>
<value>:/:cat_human_alpha1G_vhalfl</value>
<value>0</value>
</value>
<value>
<value>cat_human_alpha1G_kl</value>
<value>:/:cat_human_alpha1G_kl</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="cat_human_alpha1G_tau_n">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>lt(-56,v.Value)*( (0.8+0.025*exp(-v.Value/14.5))/cat_human_alpha1G_qt.Value ) + geq(-56,v.Value)*( (1.71*exp((v.Value+120)/38))/cat_human_alpha1G_qt.Value )</value>
</property>
<property name="VariableReferenceList">
<value>
<value>cat_human_alpha1G_tau_n</value>
<value>:/:cat_human_alpha1G_tau_n</value>
<value>1</value>
</value>
<value>
<value>v</value>
<value>:/:v</value>
<value>0</value>
</value>
<value>
<value>cat_human_alpha1G_qt</value>
<value>:/:cat_human_alpha1G_qt</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionAssignmentProcess" id="cat_human_alpha1G_tau_l">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">
<value>lt(-60,v.Value)*( (12.3+0.12*exp(-v.Value/10.8))/cat_human_alpha1G_qt.Value ) + geq(-60,v.Value)*( 137/cat_human_alpha1G_qt.Value )</value>
</property>
<property name="VariableReferenceList">
<value>
<value>cat_human_alpha1G_tau_l</value>
<value>:/:cat_human_alpha1G_tau_l</value>
<value>1</value>
</value>
<value>
<value>v</value>
<value>:/:v</value>
<value>0</value>
</value>
<value>
<value>cat_human_alpha1G_qt</value>
<value>:/:cat_human_alpha1G_qt</value>
<value>0</value>
</value>
</property>
</process>
<process class="ExpressionFluxProcess" id="cat_human_alpha1G_ntg">
<property name="StepperID">
<value>Default</value>
</property>
<property name="Expression">