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In the “Modify RNA Builder” mode after adding phosphate to nucleosides in RNA Builder, in the Sequence mode the order of nucleotides is disrupted #4892

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ViktoriaTkacheva opened this issue Jun 26, 2024 · 4 comments
Open

In the “Modify RNA Builder” mode after adding phosphate to nucleosides in RNA Builder, in the Sequence mode the order of nucleotides is disrupted #4892

ViktoriaTkacheva opened this issue Jun 26, 2024 · 4 comments
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@rrodionov91
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bug Macromolecules Priority: High RNA Builder Bucket: RNA builder related issues Sequence mode Bucket: Sequence mode related issues
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@ViktoriaTkacheva
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ViktoriaTkacheva commented Jun 26, 2024 •
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Steps to Reproduce

  1. Switch to the Macro mode

  2. Draw such a sequence of nucleosides, but it is important to manually drag each bond from AP R1 to AP R2 (do not use the “Select Connection Points” window)

    image

  3. Switch to the Sequence mode and select all letters

    image

  4. Right-click on them and choose the “Modify in RNA Builder” option

    image

  5. Select any phosphate in the RNA Builder

  6. Click on the “Update” button and choose the “Yes” option

Actual behavior
The order of nucleotides is disrupted

image

Expected behavior
After adding phosphate, the order of nucleotides remains the same

Screenshots

2024-07-04_13h36_22.mp4

Desktop (please complete the following information):

  • OS: Windows 10 Pro (version 22H2) x64
  • Browser: Сhrome
  • Version: (125.0.6422.142) x64

Ketcher version 2.22.0-rc.7, Build at 2024-06-20; 18:48:41

Issue found while testing #4388
@ViktoriaTkacheva ViktoriaTkacheva added bug Priority: High Macromolecules RNA Builder Bucket: RNA builder related issues Sequence mode Bucket: Sequence mode related issues labels Jun 26, 2024
@ViktoriaTkacheva ViktoriaTkacheva added this to the Ketcher 2.24.0-rc.1 milestone Jun 26, 2024
@AlexeyGirin
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Verified.
image

Ketcher Version 2.23.0-rc.1 Build at 2024-07-02; 08:57:41
Indigo Version 1.22.0-rc.1.0-g2bef0ce6c-wasm32-wasm-clang-19.0.0
Win 10
Chrome Version 126.0.6478.127 (Official Build) (64-bit)

@ViktoriaTkacheva
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Bug reproduced.

2024-07-04_13h36_22.mp4

@rrodionov91 rrodionov91 self-assigned this Aug 7, 2024
@rrodionov91
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Does not reproduce anymore

@rrodionov91 rrodionov91 closed this as not planned Won't fix, can't repro, duplicate, stale Aug 7, 2024
@ViktoriaTkacheva
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The bug is reproduced

2024-08-23_17h01_16.mp4

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@rrodionov91 rrodionov91

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bug Macromolecules Priority: High RNA Builder Bucket: RNA builder related issues Sequence mode Bucket: Sequence mode related issues
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@rrodionov91 @AlexeyGirin @ViktoriaTkacheva