System keeps antisense base layout and enumeration even after chain stops being antisense (and vice versa)

[AlexeyGirin]

Steps to Reproduce

1. Go to Macro - Snake mode
2. Load from HELM using paste from clipboard: RNA1{[nC62r](T)P.[nC62r](G)P.[nC62r](C)P}|RNA2{R(A)P.R(C)P.R(G)P}$RNA1,RNA2,2:pair-2:pair$$$V2.0
   
3. Remove hydrogen bond

Actual behavior
System keeps antisense base layout and enumeration even after chain stops being antisense

Expected behavior
System removes antisense base layout and change enumeration back to sense chain

As per requirement:

2.7. The antisense chain should be "flipped" in relation to the sense chain (see mockups) - bases of the new chain should be oriented in the opposite way, terminal indicators of the left-most sugar (associated with the base of a highest number) should be changed from 5' to 3' (or opposite) and/or of the left most amino acid from N to C (or opposite), and the numbering should go in the opposite direction.

If the sense chain was oriented bases down, the antisense chain should be oriented bases up.
If the sense chain was oriented bases up, the antisense chain should be oriented bases down.
If the left most sugar/amino acid of the sense chain has a terminal indicator of 5'/N, then the left most sugar/amino acid of the antisense chain should have a terminal indicator of 3'/C.
If the left most sugar/amino acid of the sense chain has a terminal indicator of 3'/C, then the left most sugar/amino acid of the antisense chain should have a terminal indicator of 5'/N.
If the numbering of the sense chain increases from left to right, the numbering of the antisense chain should increase right to left.
If the numbering of the sense chain increases from right to left, the numbering of the antisense chain should increase left to right.

Versions

• Ketcher Version 2.28.0-rc.1 Build at 2024-12-03; 17:04:52
• Indigo Version 1.27.0-rc.1.0-g8d656a341-wasm32-wasm-clang-19.0.0
• Chrome Version 131.0.6778.109 (Official Build) (64-bit)
• Win10

Issue found while testing - #5678

[rrodionov91]

Fixed in #6099. Backmerged in #6111. Not linked because github does not allow to link more than 10 issues to PR

[AlexeyGirin]

Fixed.

Versions

• Ketcher Version 2.28.0-rc.2 Build at 2024-12-10; 18:40:08
• Indigo Version 1.27.0-rc.1.0-g8d656a341-wasm32-wasm-clang-19.0.0
• Chrome Version 131.0.6778.140 (Official Build) (64-bit)
• Win10