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BND SV Calls Use 0-Based Coordinates Instead of 1-Based #536

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zaka-edd opened this issue Jan 2, 2025 · 0 comments
Open

BND SV Calls Use 0-Based Coordinates Instead of 1-Based #536

zaka-edd opened this issue Jan 2, 2025 · 0 comments

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@zaka-edd
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zaka-edd commented Jan 2, 2025

When running Sniffles2, I noticed that BND structural variant calls are being reported with 0-based coordinates instead of the expected 1-based VCF standard. For example:
chr21 24015867 Sniffles2.BND.4M26D N N[chrM:0[ 60 PASS PRECISE;SVTYPE=BND;...

In this example, chrM:0 suggests a 0-based position. This issue causes downstream compatibility problems with tools that strictly enforce 1-based VCF conventions.

Thank you for looking into this issue :)

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