Trehalose-phosphatase (IPR003337)

[sjm41]

• InterPro ID / label
  Trehalose-phosphatase (IPR003337)

• Example sequences with problematic annotation (ID + gene/protein name):
  Fly CG5177 (FBgn0031908/Q9VM18)

• Description of issue
  This entry is associated with the GO term 'catalytic activity' (following a previous review IPR003337 -> GO:0003825 #116). That high-level term isn't so helpful in itself, and it seems the signature in fly CG5177 and other plant proteins isn't associated with catalytic activity. From PMID 27469628:
  "It has been shown that the TPP (T6P phosphatase) domains of Tps1 in some plant species have lost their catalytic activity. [29]"
  "We found that recombinant Tps1-TPP and CG5171, but not CG5177, dephosphorylated T6P under our experimental conditions"
  "the function of the TPP domain proteins CG5171 and CG5177 remains unknown"

Can we remove the GO term?

[sarach06]

Hi Steven,
Many thanks for this. Yes, I removed the term from this entry and added a sentence mentioning this, with the reference you provided. It will be visible in InterPro 96.0.
Best regards,
Sara

[sjm41]

Thanks Sara.