CYTOCHROME C OXIDASE POLYPEPTIDE 7A (PTHR10510) Respirasome assembly

[hattrill]

• PTHR ID & PTN node:
  PANTHER:PTN000828143
  CYTOCHROME C OXIDASE POLYPEPTIDE 7A (PTHR10510)
• Sequences with problematic annotation (ID + gene/protein name):
  COX7A FBgn0040529
  COX7AL FBgn0037579
  COX7AL2 FBgn0085201
• Type of Issue: Erroneous source or erroneous propagation, or other issue
  mitochondrial respirasome assembly GO:0097250

In humans and mice, COX7A2L/Cox7a2l is annotated with mitochondrial respirasome assembly GO:0097250. This point is debated somewhat in the literature (PMID: 27545886,PMID:30428348), but the major issue here is that COX7A2L is very similar to COX7A1. COX7A1 has not been characterised as a respirasome assmebly factor but is a component of complex IV.

In flies,
COX7A FBgn0040529
COX7AL FBgn0037579
COX7AL2 FBgn0085201
are all more similar to human COX7A1 than COX7A2L.

Therefore block the propagation of terms from PANTHER:PTN000828143 to these genes.

This branch should be reviewed to try to separate the COX7A2L from the COX7A1 sequences.