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Revise GO:0097250 mitochondrial respirasome assembly #29227

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hattrill opened this issue Nov 14, 2024 · 0 comments
Open

Revise GO:0097250 mitochondrial respirasome assembly #29227

hattrill opened this issue Nov 14, 2024 · 0 comments
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@hattrill
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GO:0097250 mitochondrial respirasome assembly
is defined as "The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex."

and
GO:0033617 mitochondrial cytochrome c oxidase assembly
GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0034551 mitochondrial respiratory chain complex III assembly
GO:0034553 mitochondrial respiratory chain complex II assembly

have a part_of rel

But the 'respirasome' is really a grouping term for supercomplexes formed by CI, CIII and CIV. Specifically for

PMID: 30030361 and PMID:32311046 say that there are various supercomplexes of CI, CIII, CIV; the stoichiometry 1:2:1 is the 'respirasome', 2:2:2 is termed the ‘respiratory megacomplex’

As there seem to be a handful of factors that are specifically associated with the assembly of these complexes such as human HIGD1A, HIGD2A, RAB5IF, we need this term but with a few changes.

Think that we can keep the name 'mitochondrial respirasome assembly' as there is a fairly loose usage in the literature and tweak the defintion to
"The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex."

remove the has_part:
GO:0033617 mitochondrial cytochrome c oxidase assembly
GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0034551 mitochondrial respiratory chain complex III assembly
GO:0034553 mitochondrial respiratory chain complex II assembly
(if we want to group these with a parent, we should make a grouping term for the mitochondrial OXPHOS complex assembly, as respiratory is just CI-IV)

We could either place 'mitochondrial respirasome assembly' under and change the defintion of GO:0033108 mitochondrial respiratory chain complex assembly to include supercomplexes formation:
"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex or between respiratory chain complexes to form high-order structures."

or alternatively, if we want to group the assmebly of CI-CV and the respirasome, could make mitochondrial OXPHOS complex assembly term?

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