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GO:0047186, EC 2.34.1.45 has been updated #29625

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kaxelsen opened this issue Jan 30, 2025 · 2 comments
Open

GO:0047186, EC 2.34.1.45 has been updated #29625

kaxelsen opened this issue Jan 30, 2025 · 2 comments

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@kaxelsen
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kaxelsen commented Jan 30, 2025

The Go term should be updated according to the new information in EC 2.3.1.45.

Name: N-acetylneuraminate 9-O-acetyltransferase
Synonyms: N-acetylneuraminate 7(8)-O-acetyltransferase; sialate O-acetyltransferase; N-acetylneuraminate 7,8-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase; glycoprotein 7(9)-O-acetyltransferase; acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase; N-acetylneuraminate O7-(or O9-)acetyltransferase; acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase; CASD1; acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase; N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
Definition: Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-9-O-acetyl-beta-neuraminate + CoA. Source: [EC:2.3.1.45], [RHEA:81827]
Comments: The enzyme, found in animals, is essential for the formation of acetylated sialoglycans. The acetyl group has been shown to spontaneously move between the 9-O, 8-O, and 7-O positions of the neuraminate, with 9-O acetylation being most favoured.

@pgaudet
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pgaudet commented Jan 30, 2025

thanks @kaxelsen
Does that mean that this EC is no linked to https://www.rhea-db.org/rhea/20808 anymore ? GO should also remove that cross-reference?

@kaxelsen
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Exactly. RHEA:20808 will change status to obsolete.

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