Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Design topology not obeyed #3

Open
agarrubio opened this issue Nov 16, 2023 · 0 comments
Open

Design topology not obeyed #3

agarrubio opened this issue Nov 16, 2023 · 0 comments

Comments

@agarrubio
Copy link

agarrubio commented Nov 16, 2023

In the colab ipynb https://colab.research.google.com/github/generatebio/chroma/blob/main/notebooks/ChromaDemo.ipynb, I have tried 3 times to create a TIM-barrel (CATH 3.20.20) with different lengths in the range of known TIM-barrels.
None of the 3 times did I get something resembling a TIM-barrel. All three times I got a 4-strand antiparallel beta sheet, surrounded by several helices that do not form a barrel.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant