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SUGGESTION Add specific anchoring residues for alleles H2-Db, Kb, Dd, Hd and Kd from https://doi.org/10.1084/jem.20190179 #1047

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PierreLaplante opened this issue Jan 9, 2024 · 2 comments · Fixed by #1110
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SUGGESTION Add specific anchoring residues for alleles H2-Db, Kb, Dd, Hd and Kd from https://doi.org/10.1084/jem.20190179 #1047

PierreLaplante opened this issue Jan 9, 2024 · 2 comments · Fixed by #1110
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4.3.0

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@PierreLaplante
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This paper defined anchoring residues for 6 of the MHC-I mice alleles, for 8, 9, 10 and 11-mer peptides, and found increased discrimination of immunogenic neoepitopes.

Would you consider adding the option to define them as anchoring residues in the pipeline?
@susannasiebert
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This is a great suggestion. I will discuss this with the team.

@susannasiebert susannasiebert added this to the 4.1.0 milestone Jan 9, 2024
@susannasiebert susannasiebert modified the milestones: 4.1.0, 4.2.0 Feb 28, 2024
@susannasiebert susannasiebert linked a pull request Jun 12, 2024 that will close this issue
Added support for mouse specific allele anchor positions #1110
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@susannasiebert
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This feature is now available in version 4.3.0.

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Added support for mouse specific allele anchor positions ldhtnp/pVACtools
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@susannasiebert @PierreLaplante