Comparison of trajectories/DEGs for complex experimental designs

[JonasDBM]

Hi,

very cool preprint and tool!

I am curious to know if scLANE is capable of handling more complex experimental settings such as multi-condition, multi-timepoints, multi-sample scRNA seq datasets to compare DEGs along trajectories between multiple conditions.

Many thanks for your help!

Best,

Jonas

[rhondabacher]

Hi Jonas,

Thank you for the interest! Yes, scLANE can be used for this type of analysis. @jr-leary7 is out of the office this week, but when he returns he can send additional information and we'd be happy to set up a chat if it would be helpful to discuss further.

Best,
Rhonda

[JonasDBM]

Hi Rhonda,

great, many thanks for your response and offer! Looking forward to hear from @jr-leary7 but no rush! :)

Best,

Jonas

[jr-leary7]

Hi @JonasDBM -- sorry for the late response ! I'd be happy to help you out with running scLANE. I would probably recommend the GLMM mode as a starting point for your use case, but if you can tell me more about your data I can help more !

[jr-leary7]

hi @JonasDBM - any updates / further questions ?