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create modules for jaxqtl #15

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zixuanzhang opened this issue Apr 24, 2024 · 1 comment
Open

create modules for jaxqtl #15

zixuanzhang opened this issue Apr 24, 2024 · 1 comment
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enhancement New feature or request

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@zixuanzhang
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modules including:

  • cis/nominal scan for eQTL mapping
  • regression of gene expression on non-genotype covariates
  • logistic regression of PIP for cis-SNPs per gene on annotation file (i.e., nominal scan on each col of annotation)
@zixuanzhang zixuanzhang added the enhancement New feature or request label Apr 24, 2024
@zixuanzhang
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For running logistic regression on PIP, jaxQTL gives different beta and SE estimate (but similar p values) compared to statsmodel result. This is caused by different stopping rule. jaxQTL used diff in log likelihood whereas sm used diff in parameter estimate (jaxqtl can replicate sm results if use the same stopping rule).
In this case running logit on PIP instead of 0/1 outcome, using Bernoulli likelihood is probably suboptimal since here y is not Bernoulli random variable.

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