To compile and run the "game" use
make
make will automatically install all the dependencies except for SDL2 and SDL2_image, it is currently configured to copy all these files from the install location for brew on Apple Silicon (/opt/homebrew/Cellar/). You will need to install SDL2 and SDL2_image yourself and point the Makefile at the install directories, using the variables on lines 20 and 21: SDL_DIR and SDL_IMAGE.
If, for example, you ran brew install SDL2 SDL2_image on an intel chip, homebrew would install the libs and includes in /usr/local/homebrew instead, so the make file will need to be configured with this value instead.