VEP 113

[dnil]

Description of feature

Out now! 😸

https://github.com/Ensembl/ensembl-vep/releases/tag/release%2F113.0
https://grch37.ensembl.org/info/docs/tools/vep/script/vep_download.html

Nice with CADD 1.7, gnomad 4.1 and interesting with the Parlogues plugin to somewhat selectively bring in variants from paralogous regions. Thinking about that KRT6-family eg.

[jemten]

@ramprasadn has tested version 113 and found that certain BNDs are not annotated by VEP, Ensembl/ensembl-vep#1774

[dnil]

Well spotted!

[ramprasadn]

VEP 113 is now integrated into our pipeline for those interested in utilizing it.

However @dnil, it appears that BNDs overlapping intergenic variants are not being annotated by this version. The Ensembl team has acknowledged this issue and is actively investigating it. I hope they will resolve it in the next release. Given this bug, I don’t believe it is suitable for production use at CG at this time. I will close this issue for now. Please feel free to reopen it if necessary.