mixed (zero and first order) absorption model

[harishkaushikbugworks]

Hello Matt,

Iam trying to build mixed (zero and first order) absorption model of donepezil from transdermal patch application in nlmixr
I need your help in writing code for modelling these kind of profiles

Iam
Choi2015_Article_Poppk of donepezil patch.pdf
attaching the paper, iam referring to

Regards
HKK

[mattfidler]

Typically this is performed by splitting the dose in the dataset into two groups:

1. Group one is to the central compartment; In nlmixr this can be the name of the compartment like central or the compartment number like 1. The dose is the total amount of the dose the system.
2. Group two is to the depot compartment; In nlmixr this can be the name of the compartment like depot or the compartment number like 2.

In the model you would specify the depot compartment like:

model({
d/dt(depot) <- -ka*depot
d/dt(central) <- ka*depot - kel*central
f(central) <- fc
f(depot) <- 1 - fc
})

I haven't read the paper, so you should adjust the model to match the paper (ie number of compartments, maybe there is a PD component etc)