Question about install nlmixr

[vvn076725282]

Hi,officer

Could you please help me? I can't use library(nlmixr). it says

ld: warning: directory not found for option '-L/opt/R/arm64/gfortran/lib/gcc/aarch64-apple-darwin20.2.0/11.0.0'
ld: library not found for -lgfortran
clang: error: linker command failed with exit code 1 (use -v to see invocation)
make: *** [nlmixr.so] Error 1
ERROR: compilation failed for package ‘nlmixr’

• removing ‘/Library/Frameworks/R.framework/Versions/4.1-arm64/Resources/library/nlmixr’
• restoring previous ‘/Library/Frameworks/R.framework/Versions/4.1-arm64/Resources/library/nlmixr’
  Warning in install.packages :
  installation of package ‘nlmixr’ had non-zero exit status

The downloaded source packages are in
‘/private/var/folders/74/vpcrzbw13p119hdy0yclqzgh0000gn/T/RtmpYSmegO/downloaded_packages’

[vvn076725282]

Also My laptop is macbook M1

[vvn076725282]

And I already download the fortran tool-chain from https://github.com/fxcoudert/gfortran-for-macOS/releases

[mattfidler]

Thanks for your patience,

I do not have any mac computers, but I have a mac runner. The runner script is here:

https://github.com/nlmixr2/nlmixr2/blob/main/.github/workflows/R-CMD-check.yaml

For this build you have to:

• install homebrew

From homebrew you should install some tools:

brew install --cask xquartz
brew install cairo
brew install libgit2
brew install udunits

Then since you have the fortran tool-chain installed, you will need to install the links to it:

sudo ln -s /usr/local/bin/gfortran-10 /usr/local/bin/gfortran
sudo mkdir /usr/local/gfortran
sudo ln -s /usr/local/gfortran-10 /usr/local/gfortran 

Then you will have to modify your Makvars file. Start R and run the following commands:

try(dir.create("~/.R"))
writeLines(c("GCCBASE:=$(shell brew --prefix gcc)","FLIBS=-L$(GCCBASE)/lib/gcc/10/lib -lm",""),"~/.R/Makevars")

Depending on your architecture, you may need to reinstall symengine from source. First restart the R console and then use the following command:

install.packages("symengine", type="source")

After that you should be able to install RxODE and nlmixr from source.

Since this is a bit complicated, it is easier to use the docker image on the mac. @RichardHooijmaijers knows more about the docker image.