[NTR] CD57-positive enterocyte described by Stellar pipeline snRNAseq + CODEX/Phenocycler John Hickey

[emquardokus]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label

• CD57-positive enterocyte

Synonyms (add reference(s), please)
CD57+ enterocyte

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
Description:
Definition: An enterocyte of the human duodenum (small intestine) expressing CD57 or HNK-1.
Localization: Primarily enriched in the duodenum in gland structures, with rare presence in other regions of the intestine.
Characteristics: These cells exhibit a distinct profile compared to other enterocytes. They are less abundant and often found in glandular regions of the duodenum.
Significance: While CD57 is traditionally a marker for NK cells and certain T cells, in this context, it identifies a unique subset of enterocytes that may have specialized functions in the small intestine (CD57 is present on many cell types but its combination with CD45 may most likely mark immune cells. This is similar to many molecules like CD56 happy to explain more).
Definition for Cell Ontology:
CD57-positive enterocyte: An enterocyte of the human duodenum expressing beta-1,3-glucuronyltransferase 1 (B3GAT1), also known as CD57 or HNK-1. These cells have a distinct expression profile compared to other enterocytes and are enriched within the duodenal epithelium.

Hickey, John W., Winston R. Becker, Stephanie A. Nevins, Aaron Horning, Almudena Espin Perez, Chenchen Zhu, Bokai Zhu, et al. 2023. “Organization of the Human Intestine at Single-Cell Resolution.” Nature 619 (7970): 572–84. https://doi.org/10.1038/s41586-023-05915-x.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
enterocyte of epithelium proper of duodenum CL:1000340

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

human duodenum UBERON:0002114

Your ORCID
Ellen M. Quardokus 0000-0001-7655-4833
John W. Hickey 0000-0001-9961-7673

Additional notes or concerns
Additional Clarifications
Regional Localization:
CD57-positive enterocytes: Enriched in the duodenum (small intestine).
Markers Associated with Immune Cells:
While CD57 is traditionally associated with immune cells (e.g., NK cells), its expression on enterocytes marks unique epithelial subsets with specific functions or maturation states.
Disease Association:
Hickey et al 2023. Nature 619 (7970): 572–84. study focused on healthy intestinal tissues. The expression of this marker in enterocytes within healthy samples suggests that they are part of normal physiological processes rather than disease states.
Need for Specific Designations:
CD57-positive enterocytes: The expression of this marker highlights a subset with distinct maturation stages or functional roles, contributing to the diversity of the intestinal epithelium.
Summary
We identified this enterocyte type to capture the heterogeneity within the intestinal epithelium:
CD57-positive enterocytes represent a rare, specialized population in the duodenum.