2024-02-08 Release

New terms

term id	term label
HP:6000219	Reduced methylmalonate semialdehyde dehydrogenase activity in cultured fibroblasts
HP:6000218	Reduced circulating xanthine oxidase activity
HP:6000217	Reduced circulating acyl-CoA oxidase activity
HP:6000216	Reduced HMG-CoA lyase activity in cultured fibroblasts
HP:6000223	Recent history of caustic substance ingestion
HP:6000222	Painful defecation
HP:6000221	Positive stool occult blood test
HP:6000220	Pharyngeal mass
HP:6000211	Elevated CSF dihydrouracil concentration
HP:6000210	Elevated CSF N-carbamyl-beta-alanine concentration
HP:6000209	Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration
HP:6000208	Elevated CSF 5-hydroxymethyluracil concentration
HP:6000215	Reduced circulating 3-hydroxyisobutyryl-CoA hydrolase activity
HP:6000214	Decreased 3-hydroxyisobutyrate dehydrogenase activity
HP:6000213	Elevated circulating Angiotensin-converting enzyme concentration
HP:6000212	Elevated CSF dihydrothymine concentration
HP:6000203	Elevated CSF cholestanol concentration
HP:6000202	Cerebrospinal fluid erythrocytes
HP:6000201	Reduced hepatic glucose-6-phosphate translocase activity
HP:6000200	Reduced hepatic glucose-6-phosphatase activity
HP:6000207	Elevated CSF thymine concentration
HP:6000206	Reduced CSF pyridoxal-5'-phosphate concentration
HP:6000205	Elevated CSF myelin basic protein concentration
HP:6000204	Elevated CSF apolipoprotein B concentration
HP:6000195	Elevated mitochondrial citrate synthase synthase activity
HP:6000194	History of adrenalectomy
HP:6000193	Anti-osteoprotegerin antibody positivity
HP:6000192	Silica dust exposure
HP:6000199	Reduced 3-beta-hydroxysteroid-delta-5-desaturase activity in cultured fibroblasts
HP:6000198	Reduced muscle phosphorylase kinase activity
HP:6000197	Reduced muscle phosphoglycerate mutase activity
HP:6000196	Reduced muscle lactate dehydrogenase activity
HP:6000251	Small intestinal intraepithelial lymphocytosis
HP:6000250	Gastric intraepithelial lymphocytosis
HP:6000249	Enlarged gastric folds
HP:6000248	Synovial fluid crystals
HP:6000255	Demonstration of Leishmania in tissue
HP:6000254	Abnormal proximal convoluted tubule morphology
HP:6000253	Necrotizing vasculitis
HP:6000252	Fetal lung hyperechogenicity
HP:6000243	Reduced circulating cortisol-binding globulin concentration
HP:6000242	Decreased circulating complement component 1s concentration
HP:6000241	Diminished prolactin response to thyrotrophin-releasing hormone stimulation
HP:6000240	Reduced circulating pyrimidine 5-prime-nucleotidase activity
HP:6000247	Esophageal mass
HP:6000246	Elevated CSF D-2-hydroxyglutaric acid concentration
HP:6000245	Elevated circulating granulocyte-macrophage colony-stimulating factor concentration
HP:6000244	Decreased circulating thyroglobulin concentration
HP:6000235	Inappropriately low concentration of acetoacetate
HP:6000234	Elevated circulating dihydroxyphenylacetic acid concentration
HP:6000233	Carcinoid tumor of the pancreas
HP:6000232	Splenic necrosis
HP:6000239	Elevated circulating tumor necrosis factor alpha concentration
HP:6000238	Elevated CSF 5-amino-4-imidazolecarboxyamide concentration
HP:6000237	Elevated circulating 3-hydroxybutyryl-carnitine concentration
HP:6000236	Iappropriately low concentration of beta-hydroxybutyrate
HP:6000227	Prosthetic heart valve
HP:6000226	Elevated aortic transvalvular pressure gradient
HP:6000225	Single second heart sound
HP:6000224	Delayed passage of meconium
HP:6000231	Abnormal tissue enzyme activity
HP:6000230	Decreased muscle caveolin-3 level
HP:6000229	High-set nipples
HP:6000228	Failure to increase oxygen saturation on hyperoxia test
HP:6000187	Anti-thrombospondin type I domain-containing 7A antibody positivity
HP:6000186	Anti-soluble liver antigen/liver pancreas antibody positivity
HP:6000185	Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio
HP:6000184	Filum terminale lipoma
HP:6000191	Seminal vesicle cyst
HP:6000190	Abnormal seminal vesicle morphology
HP:6000189	Decreased circulating ficolin 3 concentration
HP:6000188	Antisperm antibody positivity
HP:6000179	History of gastric bypass surgery
HP:6000178	Purulent drainage from Stensen duct
HP:6000177	Uvular swelling
HP:6000176	Anterior neck swelling
HP:6000183	Thickened tympanic membrane
HP:6000182	Absent otoacoustic emissions
HP:6000181	History of radiation therapy
HP:6000180	Triggered by volatile organic compounds
HP:6000175	Occipital location
HP:6000174	Lateral neck mass
HP:6000173	Ear pain exacerbated by manipulating tragus or pinna
HP:6000172	Tympanic membrane bulging
HP:6000275	4-hydroxyphenyllactic aciduria
HP:6000274	2--hydroxyphenylacetic aciduria
HP:6000273	Elevated circulating decanoylcarnitine concentration
HP:6000272	Elevated circulating octanoylcarnitine concentration
HP:6000267	Elevated circulating methionine sulfoxide concentration
HP:6000266	2-oxoadipic aciduria
HP:6000265	Elevated urinary 3-hydroxykynurenine level
HP:6000264	Fetal tachycardia
HP:6000271	Elevated circulating glycylproline concentration
HP:6000270	Elevated CSF saccharopine concentration ...

2024-01-16 Release

Important note about this release

This "patch release" was necessary due to two lost subclass axioms ("Cleft lower alveolar ridge" and "Cleft lip") in the previous release. Please use today's release instead of https://github.com/obophenotype/human-phenotype-ontology/releases/tag/v2024-01-11.

New HPO terms

term id	term label
HP:6000171	Abdominal wall mass
HP:6000170	Pain alleviated by testicle elevation
HP:6000169	History of total parenteral nutrition dependence
HP:6000168	History of recent central venous catheter
HP:6000163	Shoulder localization
HP:6000162	Excessive licorice consumption
HP:6000167	Use of intrauterine device
HP:6000166	Maternal zinc deficiency
HP:6000165	Maternal folate deficiency
HP:6000164	Pregnancy conceived despite intrauterine device

Full Changelog: v2024-01-11...v2024-01-16

2024-01-11 Release

Important note about this release

A "patch release" was necessary due to two lost subclass axioms ("Cleft lower alveolar ridge" and "Cleft lip") in the this release. Please use this release instead: https://github.com/obophenotype/human-phenotype-ontology/releases/tag/v2024-01-16.

New Terms

HPO ID	HPO Label
HP:4000214	Diminished breath sounds
HP:6000091	Postpartum exacerbation
HP:6000090	Dermal flame figures
HP:6000089	Brown tumor
HP:6000088	Reduced muscle alpha-1,4-glucosidase activity
HP:6000095	Draining sinus tract in skin
HP:6000094	History of outdoor activities
HP:6000093	Propylthiouracil exposure
HP:6000092	Retinoid exposure
HP:6000083	Reduced hepatic dihydropyrimidinase activity
HP:6000082	Reduced hepatic beta-ureidopropionase activity
HP:6000081	Reduced alpha-aminoadipic semialdehyde synthase activity in cultured fibroblasts
HP:6000080	Reduced phosphoserine phosphatase activity in cultured fibroblasts
HP:6000087	Penile swelling
HP:6000086	History of urethral procedure or catheterization
HP:6000085	Angulation of penis
HP:6000084	Sunken fontanelle
HP:6000075	Subcutaneous arteriolar thrombosis
HP:6000074	Pharyngeal myxoma
HP:6000073	Renal lymphangiectasia
HP:6000072	Thinning of outer muscular layer of small bowel
HP:6000079	Metachromatic intraneuronal lipid deposits
HP:6000078	Nasal hamartoma
HP:6000077	Pancreatic islet beta cell iron deposition
HP:6000076	Renal vasculitis
HP:6000067	Increased myocardial pyrophosphate uptake
HP:6000066	Triggered by extension of leg
HP:6000065	Esophageal fibrosis
HP:6000064	Excessive eructation
HP:6000071	Heterotopic dermal ossification
HP:6000070	Cutaneous granuloma
HP:6000069	Brief tear break-up time
HP:6000068	Ameliorated by nerve block
HP:6000123	Elevated urinary 2'-deoxyadenosine level
HP:6000122	Increased urinary N-acetylglucosamine-rich oligosaccharide level
HP:6000121	Elevated urinary xanthurenic acid level
HP:6000120	Elevated urinary sulfatide level
HP:6000127	Elevated urinary creatine/creatinine ratio
HP:6000126	Decreased urinary bile acid level
HP:6000125	Elevated urinary dolichol level
HP:6000124	Positive 2,4-dinitrophenylhydrazine urine test
HP:6000115	Decreased urine creatinine level
HP:6000114	Elevated urinary 5-hydroxymethyluracil level
HP:6000113	Elevated urinary succinyladenosine level
HP:6000112	Hockey-stick palmar crease
HP:6000119	Elevated urinary dihydrothymine level
HP:6000118	Elevated urinary dihydrouracil level
HP:6000117	Elevated urinary AICA-riboside level
HP:6000116	Elevated urinary deoxyuridine level
HP:6000107	Cervical motion tenderness
HP:6000106	Costovertebral angle tenderness
HP:6000105	Vaginal mass
HP:6000104	Twin pregnancy
HP:6000111	Monoarticular
HP:6000110	Large joint predominance
HP:6000109	Supernumerary finger flexion crease
HP:6000108	Abnormal penile discharge
HP:6000099	Airway mucosal thickening
HP:6000098	Contact lens wearer
HP:6000097	Spontaneous lens capsule rupture
HP:6000096	Corneal transplant history
HP:6000103	Precipitous labor
HP:6000102	Breast intraductal papilloma
HP:6000101	Corneopalpebral synechiae
HP:6000100	Hyperpolarized transepithelial nasal potential difference
HP:6000027	Oil-drop brown pigmentation of the corneal limbus
HP:6000026	History of spicy food intake
HP:6000025	Dark cerumen
HP:6000024	Synesthesia
HP:6000031	Phaeohyphomycosis
HP:6000030	Placidity
HP:6000029	Social Anxiety
HP:6000028	Hazardous alcohol use
HP:6000019	Anthracycline exposure
HP:6000018	Internal anal sphincter achalasia
HP:6000017	Elevated circulating soluble FASL concentration
HP:6000016	Elevated circulating vitamin B12 concentration
HP:6000023	Lack of sufficient daily physical activity
HP:6000022	Collagenoma
HP:6000021	Decreased circulating thrombopoietin concentration
HP:6000020	Binge drinking
HP:6000011	Excessive guilt
HP:6000010	Linear Hyperpigmentation along Blaschko's lines
HP:6000009	Cerebriform connective tissue nevus
HP:6000008	Hemidiaphragm elevation
HP:6000015	Tympanic membrane hypermobility
HP:6000014	Pain worse when lying flat ...

2023-10-09 Release

New Terms

term id	term label
HP:4000189	Elevated circulating neuron-specific enolase concentration
HP:4000191	Increased circulating alpha-mannosidase activity
HP:4000190	Reduced leukocyte alpha-mannosidase activity
HP:4000213	Elevated circulating hyaluronic acid concentration
HP:4000212	Increased circulating vitamin A concentration
HP:4000209	Abnormal erythrocyte adenosine deaminase activity
HP:4000208	Reduced erythrocyte galactose-1-phosphate uridylyltransferase activity
HP:4000211	Reduced glycerol kinase activity in cultured fibroblasts
HP:4000210	Reduced isovaleryl CoA dehydrogenase activity in cultured fibroblasts
HP:4000205	Reduced beta-mannosidase activity in cultured fibroblasts
HP:4000204	Reduced mitochondrial acetyl-CoA acetyltransferase activity in cultured fibroblasts
HP:4000207	Reduced branched-chain alpha-keto acid dehydrogenase activity in cultured fibroblasts
HP:4000206	Reduced 3-methylcrotonyl CoA carboxylase activity in cultured fibroblasts
HP:4000201	Abnormal circulating alpha mannosidase activity
HP:4000200	Reduced holocarboxylase synthetase activity in cultured fibroblasts
HP:4000203	Reduced erythrocyte arginase activity
HP:4000202	Reduced alpha-N-acetylgalactosaminidase activity in cultured fibroblasts
HP:4000197	Reduced N-acetylgalactosamine-6-sulfate sulfatase in cultured fibroblasts
HP:4000196	Reduced heparan-alpha-glucosaminide N-acetyltransferase activity in cultured fibroblasts
HP:4000199	Reduced erythrocyte porphobilinogen deaminase activity
HP:4000198	Reduced acetylglucosamine-6-sulfate sulfatase activity in cultured fibroblasts
HP:4000193	Reduced leukocyte N-sulfoglucosamine sulfohydrolase activity
HP:4000192	Reduced leukocyte cathepsin D activity
HP:4000195	Abnormal enzyme activity in cultured fibroblasts
HP:4000194	Pseudohyperkalemia
HP:0020224	Mammary duct ectasia
HP:0020225	Breast abscess
HP:0020226	Nipple tenderness
HP:0020227	Floating gallbladder
HP:5200207	Inattentiveness illusion
HP:5200205	Illusions
HP:5200204	Disturbed perception with a stimulus
HP:5200203	Proprioceptive hallucination
HP:5200202	Abnormal interpretation of external stimuli
HP:5200201	Gustatory hallucination
HP:5200200	Olfactory hallucination
HP:5200221	Decreased comfort with casual physical contact
HP:5200220	Decreased facial expression reciprocity
HP:5200218	Derealization
HP:5200217	Depersonalization
HP:5200216	Abnormal perceptual state
HP:5200215	Visceral hallucination
HP:5200214	Somatic hallucination
HP:5200213	Decreased emotional vulnerability
HP:5200212	Increased social interactions
HP:5200211	Subjective eidetic images
HP:5200210	Autoscopy
HP:5200209	Pareidolia
HP:5200208	Illusions due to affect
HP:5200239	Consonant expressive impediment
HP:5200238	Vowel expressive impediment
HP:5200237	Pronunciation difficulties
HP:5200235	Thought disorder
HP:5200234	Flight of ideas
HP:5200233	Anticipatory anxiety
HP:5200232	Phobia
HP:5200231	Hypervigilance
HP:5200230	Maladaptive fear-related cognitions
HP:5200227	Thought blocking
HP:5200243	Abnormal change in social behavior
HP:5200242	Cognitive distortion
HP:5200241	Recurrent maladaptive behavior
HP:5200240	Delayed spoken language comprehension
HP:5200335	Addictive sex behavior
HP:5200334	Addictive gambling behavior
HP:5200333	Addictive spending behavior
HP:5200332	Addictive non-substance behaviors
HP:5200331	Addictive sedative use
HP:5200330	Suicide behaviors
HP:5200329	Problematic alcohol consumption
HP:5200328	Decreased emotional expression
HP:5200327	Decreased sexual behavior
HP:5200325	Increased comfort with casual physical contact
HP:5200323	Increased emotional vulnerability
HP:5200322	Increased emotional expression
HP:5200321	Increased sexual behavior
HP:5200320	Decreased seeking of relationships
HP:5200342	Autophagia
HP:5200341	Addictive cannabis use
HP:5200339	Self-cutting
HP:5200338	Excessive fire setting
HP:5200337	Compulsive stealing
HP:5200336	Addictive video game use
HP:5200363	Prolonged NREM sleep
HP:5200362	Short NREM sleep
HP:5200361	Prolonged rem sleep
HP:5200360	Short rem sleep
HP:5200359	Prolonged N3 sleep
HP:5200358	Prolonged N2 sleep
HP:5200357	Prolonged N1 sleep
HP:5200356	Sleep onset rapid eye movement period
HP:5200353	Hypnopompic sle...

2023-09-01 Release

New features

• The Japanese and Spanish translations have been added to HPO! The Japanese Language profiles were developed by GEM Japan Clinical Phenotype group for the purpose of precise phenotyping of patients in genome projects. Expert translation by clinical geneticists and AI translation were utilized. It has been used widely in clinical genome projects for rare diseases in Japan. The Spanish translation is a collaboration by
  • INGEMM- Institute of Medical and Molecula Genetics-Hospital Univ. La Paz, IdiPAZ and CIBER, Madrid, Spain
  • CIACER y Laboratorio de Medicina Genómica, Universidad Icesi, Cali, Colombia
  • Instituto de Genética Humana, Facultad de Medicina, Bogotá, Colombia
  • Department of Pediatrics, Hospital Univ. Doce de Octubre, Madrid, Spain
  • Grupo de Investigación en Enfermedades Raras, Laboratorio de (Epi)Genética Molecular, BioAraba, Hospital Univ.Araba - Txagorritxu. Spain.

New terms

term id	term label
HP:0035015	Elevated circulating short-chain acylcarnitine concentration
HP:0035016	Elevated circulating C4 acylcarnitine concentration
HP:0035017	Elevated circulating medium-chain acylcarnitine concentration
HP:0035018	Elevated circulating long-chain acylcarnitine concentration
HP:0035019	Elevated circulating C5 acylcarnitine concentration
HP:0035020	Elevated circulating C18 acylcarnitine concentration
HP:0035021	Elevated circulating C16 acylcarnitine concentration
HP:0035022	Elevated circulating very long-chain acylcarnitine concentration
HP:0035023	Elevated circulating acetylcarnitine concentration
HP:0035024	Elevated circulating methylmalonylcarnitine concentration
HP:0035025	Elevated circulating 3-hydroxyhexadecanoylcarnitine concentration
HP:0035026	Elevated circulating C6 acylcarnitine concentration
HP:0035027	Elevated circulating methylglutarylcarnitine concentration
HP:0035028	Elevated circulating 3-hydroxyisovalerylcarnitine concentration
HP:0035029	Elevated circulating 3-hydroxyhexanoylcarnitine concentration
HP:0035030	Elevated circulating carnitine concentration
HP:0035031	Elevated circulating tiglylcarnitine concentration
HP:0035032	Reduced circulating acetylcarnitine concentration
HP:0035033	Reduced circulating octadecenoylcarnitine concentration
HP:4000187	Spermatogonial maturation arrest

Other changes

• Remove a few new-line characters in comments and definitions by @matentzn in #9937
• remove assertion that abn digestive system is child of neoplasm by @LCCarmody in #10019
• Adding Japanese and Spanish language translations to HPO by @matentzn in #10009
• Rename contralateral injury by @matentzn in #10022
• Refresh imported terms by @matentzn in #10059

Full Changelog: v2023-07-21...v2023-09-01

2023-07-21 Release

New terms

term id	term label
HP:0034794	Pyriform sperm head
HP:0034795	Excess residual spermatozoal cytoplasm
HP:0034796	Cardiomyocyte hyaline bodies
HP:0034797	Hepatic hemophagocytosis
HP:0034798	CSF hemophagocytosis
HP:0034799	Splenic hemophagocytosis
HP:0034800	Urinary bladder granulomatosis
HP:0034801	Epidermal necrosis
HP:0034802	Exacerbated by flexion
HP:0034803	Hemolacria
HP:0034804	Corneal foreign body sensation
HP:0034805	Buttock pain
HP:0034806	Vaginal foreign body sensation
HP:0034807	Paroxysmal nocturnal dyspnea
HP:0034808	Eyelid pain
HP:0034809	Abnormal sperm physiology
HP:0034810	Small acrosomal area
HP:0034811	Bent sperm flagella
HP:0034812	Spermiation failure
HP:0034813	Hypospermatogenesis
HP:0034814	Conjunctival membrane
HP:0034815	Extreme oligozoospermia
HP:0034816	Mild oligozoospermia
HP:0034817	Moderate oligozoospermia
HP:0034818	Severe oligozoospermia
HP:0034819	Iris nodule
HP:0034820	Koeppe nodules
HP:0034821	Bussaca nodules
HP:0034822	Abnormal CSF ion concentration
HP:0034823	Decreased CSF copper concentration
HP:0034824	Diffuse pulmonary lymphoid hyperplasia
HP:0034825	Ameliorated by steroid medication
HP:0034826	Triggered by medication exposure
HP:0034827	Triggered by levothyroxin exposure
HP:0034828	Reduced muscle laminin alpha-2 chain staining
HP:0034829	Adrenal cortical sclerosis
HP:0034830	Reduced hepatic fructose-1,6-phosphate aldolase activity
HP:0034831	Pancreatic hamartoma
HP:0034832	Liver angiomyolipoma
HP:0034833	Cardiac lipoma
HP:0034834	Peripheral nerve polyglucosan inclusion bodies
HP:0034835	Cardiac polyglucosan accumulation
HP:0034836	Cystic nephroma
HP:0034837	Absent dermal elastic fibers
HP:0034838	Cleavage at junction of stratum corneum and stratum granulosum
HP:0034839	Lymphoid hyperplasia
HP:0034840	Absence of epidermal lamellar bodies
HP:0034841	Gastrointestinal granulomatosis
HP:0034842	Enlarged sperm head vacuole
HP:0034843	Ureteral hamartoma
HP:0034844	Fetal methimazole exposure
HP:0034845	Fetal procarbazine exposure
HP:0034846	Fetal fluorouracil exposure
HP:0034847	Fetal cytarabine exposure
HP:0034848	Fetal tetracycline exposure
HP:0034849	Fetal quinine exposure
HP:0034850	Fetal cyclophosphamide exposure
HP:0034851	Fetal metronidazole exposure
HP:0034852	Fetal phenobarbital exposure
HP:0034853	Fetal phenytoin exposure
HP:0034854	Periumbilical
HP:0034855	Maternal obesity during pregnancy
HP:0034856	Maternal amniocentesis
HP:0034857	Typified by highly variable age of onset
HP:0034858	Abnormal leukocyte enzyme concentration or activity
HP:0034859	Reduced leukocyte beta-glucuronidase activity
HP:0034860	Reduced leukocyte alpha-L-fucosidase activity
HP:0034861	Reduced leukocyte arylsulfatase B activity
HP:0034862	Reduced leukocyte steroid sulfatase activity
HP:0034863	Reduced leukocyte arylsulfatase A activity
HP:0034864	Decreased alpha-galactosidase A activity
HP:0034865	Positive fecal parasite test
HP:0034866	Positive stool infectious agent test
HP:0034867	Positive stool giardia antigen
HP:0034868	Entamoeba histolytica antibody positive in stool
HP:0034869	Reduced erythrocyte free porphyrin concentration
HP:0034870	Reduced circulating urocanic acid concentration
HP:0034871	Decreased urinary epinephrine level
HP:0034872	Decreased CSF epinephrine concentration
HP:0034873	Decreased circulating epinephrine concentration
HP:0034874	Decreased circulating norepinephrine concentration
HP:0034875	Decreased urinary norepinephrine level
HP:0034876	Decreased urinary metaepinephrine level
HP:0034877	Decreased CSF metanephrine concentration
HP:0034878	Decreased circulating metanephrine concentration
HP:0034879	Ovarian mass
HP:0034880	Adrenal mass
HP:0034881	Uterine mass
HP:0034882	Prostatic calculus
HP:0034883	Decreased portal vein velocity
HP:0034884	Uterine cervix mass
HP:0034885	Abnormal urinary uromodulin level
HP:0034886	Decreased urinary uromodulin level
HP:0034887	Increased urine phenylacetylglutamine level
HP:0034888	Decreased urine guanidinoacetic acid level
HP:0034889	Positive urine infectious agent nucleid acid test
HP:0034890	Positive CMV urine nucleic acid test
HP:0034891	Positive Neisseria gonorrhoeae urine nucleic acid test
HP:0034892	Positive enterovirus urine nucleic acid test
HP:0034893	Elevated brain glycine level by MRS
HP:0034894	Elevated brain polyol compounds by MRS
HP:0034895	Elevated brain gamma-aminobutyric acid by MRS
HP:0034896	History of recent anticoagulant ingestion
HP:0034897	Decreased circulating antidiuretic hormone concentration
HP:0034898	Elevated circulating growth hormone-releasing hormone concentration
HP:0034899	Abnormal amniotic fluid protein concentration
HP:0034900	Decreased amniotic fluid alpha-fetoprotein concentration
HP:0034901	Increased circulating vitamin E concentration
HP:0034902	Abnormal circulating calcitonin concentration
HP:0034903	Decreased circulating calcitonin concentration
HP:0034904	Decreased circulating thyrotropin releasing hormone concentration
HP:0034905	Elevated circulating uroporphyrin concentration
HP:0034906	Increased urine pentacarboxylporphyrin level
HP:0034907	Increased urine hexacarboxylporphyrin level
HP:...

2023-06-17 Release

New with this release

• 44 new terms, many of which are behavioural phenotypes. This release, soon after the previous one, was performed to accommodate for a user meetup on the subject.

New terms:

HPO ID	Label
HP:0034782	Obstipation
HP:0034783	Posttussive emesis
HP:0034784	Vasculitis by anatomical site
HP:0034785	Vasculitis by histology
HP:0034786	Leukocytoclastic vasculitis
HP:0034787	Accumulation of lipid droplets in small-bowel enterocytes
HP:0034788	Pericardial friction rub
HP:0034789	Muscular vasculitis
HP:0034790	Abnormal muscle succinate dehydrogenase staining
HP:0034791	Increased muscle succinate dehydrogenase staining
HP:0034792	Decreased muscle succinate dehydrogenase staining
HP:0034793	Small intestinal hamartoma
HP:5200111	Avoids emotional intimacy
HP:5200110	Preferes being alone
HP:5200108	Nonfunctional or atypical use of objects in play
HP:5200105	Reduced imaginative play skills
HP:5200104	Abnormal play
HP:5200103	Reduced social responsiveness
HP:5200102	Reduced social smiling
HP:5200101	Limited Repertoire of gestures
HP:5200100	Facial expressions not directed to others
HP:5200127	Aggression toward non caregivers
HP:5200126	Aggression toward cargivers
HP:5200125	Aggression toward others
HP:5200124	Indifference to social norms
HP:5200123	Abnormal response to social norms
HP:5200122	Difficulty communicating ones emotions
HP:5200121	Treats people like objects
HP:5200120	Abnormality in emotional social interactions
HP:5200119	Difficulty understanding humor
HP:5200118	Difficulty recognizing another's emotions
HP:5200117	Poor recognition of injustice
HP:5200116	Difficulty understanding nonliteral meaning of conversation
HP:5200113	Offers information
HP:5200137	Reduced attempt to get or direct attention of peers
HP:5200136	Reduced social reciprocity with peers
HP:5200135	Delay in the acquisition of play skills
HP:5200134	Jumping
HP:5200133	Intense attachment to unusual objects
HP:5200132	Atypical sensory examination of objects
HP:5200131	Reduced use of language for social purposes
HP:5200130	Insistence on sameness
HP:5200129	Abnormal rituals
HP:5200128	Deficit applying language skills across context

Other changes

• Fix grouped xrefs in HP:0010780 by @cthoyt in #9812
• Replace behavior terms by @LCCarmody in #9811
• Behaviours june 2023, 2nd attempt by @matentzn in #9816
• June 17th 2023 release by @matentzn in #9849
• Check for making sure all HP terms have parents and labels by @matentzn in #9846
  Full Changelog: v2023-06-06...v2023-06-17

2023-06-06 Release

New features

• hp.json now contains only HPO terms, not imported terms
• Added the Chinese language profile to HPO International Edition, provided by https://www.chinahpo.net/chpo/About.html
• Added partial translations for Nyangumarta, Dusun, Tiwi to HPO International Edition

New terms

HPO ID	Label
HP:0034693	Reduced hepatic methionine adenosyltransferase activity
HP:0034694	Substantia nigra dopaminergic neuron loss
HP:0034696	Intramuscular lipoma
HP:0034697	Cutaneous telangiectasia
HP:0034698	Abnormal aromatase activity
HP:0034699	Elevated aromatase activity
HP:0034700	Reduced aromatase activity
HP:0034701	Corneal amyloidosis
HP:0034702	Abnormal keratinocyte morphology
HP:0034703	Keratinocyte vacuolization
HP:0034704	Parotid gland adenocarcinoma
HP:0034705	Pulmonary vasculitis
HP:0034706	Reduced hepatic D-glycerate kinase activity
HP:0034707	Lymph-node hemophagocytosis
HP:0034708	Superior pubic ramus hypoplasia
HP:0034709	Uterine adenofibroma
HP:0034710	Pulmonary hamartoma
HP:0034711	Peripheral axonal distension
HP:0034712	Decreased alpha-mannosidase activity
HP:0034713	Abnormal hepatocyte morphology
HP:0034714	Hepatic melanin-like lysosomal pigmentation
HP:0034715	Reduced uroporphyrinogen decarboxylase activity
HP:0034716	Reduced heme oxygenase activity
HP:0034717	Cerebral cortex swollen achromatic neurons
HP:0034718	Vacuolated hepatocytes
HP:0034719	Lack of oocyte pronucleus formation
HP:0034720	Self-healing squamous epithelioma
HP:0034721	Elevated circulating pristanic acid concentration
HP:0034722	Sarcoplasmic bodies
HP:0034723	Elevated CSF hydroxyproline concentration
HP:0034724	Reduced CSF cystine concentration
HP:0034725	Abnormal beta-mannosidase activity
HP:0034726	Elevated beta-mannosidase activity
HP:0034727	Reduced alpha-L-fucosidase activity
HP:0034728	Abnormal alpha-L-fucosidase activity
HP:0034729	Elevated alpha-L-fucosidase activity
HP:0034730	Elevated circulating S-adenosyl-L-homocysteine concentration
HP:0034731	Elevated circulating S-adenosyl-L-methionine concentration
HP:0034732	Exercise-triggered malignant hyperthermia
HP:0034733	Anesthesic-triggered malignant hyperthermia
HP:0034734	Elevated CSF argininosuccinic acid concentration
HP:0034735	Elevated CSF aspartylglucosamine concentration
HP:0034736	Elevated circulating alpha-oxoadipic acid concentration
HP:0034737	Abnormal erythrocyte metabolite concentration
HP:0034738	Reduced erythrocyte glutathione concentration
HP:0034739	Elevated CSF sarcosine concentration
HP:0034740	Reduced CSF methionine concentration
HP:0034741	Elevated circulating homoarginine concentration
HP:0034742	Elevated urinary formiminoglutamic acid level
HP:0034743	Elevated CSF proline concentration
HP:0034744	Elevated urinary S-sulfocysteine level
HP:0034745	Elevated circulating S-sulfocysteine concentration
HP:0034746	Sertoli cell hyperplasia
HP:0034747	CSF infectious agent
HP:0034748	CSF mycobacteria
HP:0034749	Fungal bloodstream infection
HP:0034750	Supraclavicular lymphadenopathy
HP:0034751	Inguinal lymphadenopathy
HP:0034752	Axillary lymphadenopathy
HP:0034753	Positive Murphy sign
HP:0034754	Bilious emesis
HP:0034755	Ameliorated by NSAID
HP:0034756	Maternal exposure history
HP:0034757	Maternal barbiturate exposure
HP:0034758	Maternal narcotic exposure
HP:0034759	Ameliorated by ethosuximide
HP:0034760	Reduced epidermal extracellular matrix protein 1 protein expression
HP:0034761	Neurofibroma by anatomical location
HP:0034762	Tongue neurofibroma
HP:0034763	Cardiac neurofibroma
HP:0034764	Gastric neurofibroma
HP:0034765	Renal neurofibroma
HP:0034766	Muscle fiber polyglucosan inclusion bodies
HP:0034767	Abnormal rete ridge morphology
HP:0034768	Rete ridge elongation
HP:0034769	Pulmonary Langerhans cell histiocytosis
HP:0034770	Lumbar hypolordosis
HP:0034771	Battle sign
HP:0034772	Decreased skull base length
HP:0034773	Oscillopsia
HP:0034774	Decreased blink rate
HP:0034775	Abnormal blink rate
HP:0034776	Elevated blink rate
HP:0034777	Purulent sputum
HP:0034778	Maternal hyperthyroidism
HP:0034779	Perineal
HP:0034780	Gadolinium exposure
HP:0034781	Purulent parotid gland drainage
HP:4000184	Reduced erythrocyte adenosine triphosphate concentration
HP:4000186	Elevated erythrocyte adenosine triphosphate concentration
HP:4000183	Abnormal erythrocyte adenosine triphosphate concentration
HP:5201014	Asymmetric bilateral cleft lip
HP:5201013	Microform bilateral cleft lip
HP:5201012	Incomplete bilateral cleft lip
HP:5201011	Complete bilateral cleft lip
HP:5201010	Microform cleft of the upper lip
HP:5201009	Complete cleft of the upper lip

Pull requests

• Make sure hp.json is the simple product without external terms by @matentzn in #9715
• Update Scott B contributor ORCID by @matentzn in #9718
• Update hp.Makefile by @iimpulse in #9735
• Harmonise ORCIDs contribution ctd. by @matentzn in #9747
• Add Chinese translation (CHPO release on 20230511) by @kaichop in #9772
• Add all-translations table to HPO by @matentzn in #9739
• new terms for bilateral cleft lips by @sabrinatoro in #9710
• Add Nyangumarta, Dusun, Tiwi to HPO international by @matentzn in #9784
• HPO release 6 June 2023 by @matentzn in #9789

New Contributors

• @kaichop made their...

2023-04-05 Release

New Features

• you can now find an international version of HPO at http://purl.obolibrary.org/obo/hp/hp-international.owl. This will contain translations of many HPO phenotypes into french, czech, turkish and dutch. More languages are being added in future releases.
• The individual language profiles can be browsed at https://github.com/obophenotype/human-phenotype-ontology/tree/master/src/ontology/translations, and accessed using the persistent IRI prefix http://purl.obolibrary.org/obo/hp/translations/, for example: http://purl.obolibrary.org/obo/hp/translations/hp-fr.babelon.tsv to obtain the latest french language profile as a spreadsheet. We do not currently provided official PURLs for the versioned language profiles, but they can be accessed using regular GitHub versioning like this: https://github.com/obophenotype/human-phenotype-ontology/blob/v2023-04-05/src/ontology/translations/hp-fr.babelon.tsv.
• The French translation of HPO is carried out by INSERM, US14- Orphanet, with funding from the French Ministry of Health, Direction Générale de la Santé, in the framework of the French National Plan for Rare Diseases.

New Terms

HPO ID	Label
HP:0034521	Periorificial hyperkeratosis
HP:0034522	Eosinophilic lymph node infiltration
HP:0034523	Blood parasite
HP:0034524	Bloodstream trypomastigotes
HP:0034525	Adamantinoma
HP:0034526	Abnormal enzyme activity in muscle tissue
HP:0034527	Reduced muscle phosphoglycerate kinase activity
HP:0034528	Reduced fibroblast type III procollagen synthesis
HP:0034529	Reduced muscle myoadenylate deaminase activity
HP:0034530	Bent long bone
HP:0034531	Tracheal rupture
HP:0034532	Increased myocardial glycogen content
HP:0034533	Triggered by monoamine oxidase inhibitor
HP:0034534	Triggered by serotonin reuptake inhibitor
HP:0034535	Ameliorated by acetazolamide
HP:0034536	Ameliorated by exposure to medication
HP:0034537	Ameliorated by vitamin B12
HP:0034538	Ameliorated by thiamine
HP:0034539	Ameliorated by dantrolene
HP:0034540	Ameliorated by biotin
HP:0034541	Reduced bone-marrow megakaryocyte size
HP:0034542	Hairshafts with longitudinal grooves
HP:0034543	Mycobacterium bacteremia
HP:0034544	Decreased delta-aminolevulinate dehydratase activity
HP:0034545	Elevated circulating pancreatic secretory trypsin inhibitor activity
HP:0034546	Presence of uterus in 46,XY individual
HP:0034547	Intraluminal meconium calcification
HP:0034548	Portal vein hypoplasia
HP:0034549	Adrenal leiomyoma
HP:0034550	Small intestinal lymphoplasmacytic infiltrate
HP:0034551	Triggered by neuroleptic medication
HP:0034552	Abnormal peroxisomal morphology
HP:0034553	Absence of peroxisomes
HP:0034554	Paucity of peroxisomes
HP:0034555	Reduced sulfide:quinone oxidoreductase activity
HP:0034556	Deficit at segmental level
HP:0034557	Rhabdoid tumor
HP:0034558	Rhabdoid tumor of the ovary
HP:0034559	Cardiac rhabdoid tumor
HP:0034560	Malignant rhabdoid tumor of the bladder
HP:0034561	Malignant rhabdoid tumor of liver
HP:0034562	Malignant rhabdoid tumor of muscle
HP:0034563	Neck teratoma
HP:0034564	Kidney teratoma
HP:0034565	Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level
HP:0034566	Aplasia of posterior communicating artery
HP:0034567	Optic pit
HP:0034568	Ameliorated by naloxone
HP:0034569	Ameliorated by pyridoxal phosphate
HP:0034570	Thickened intrahepatic portal venules
HP:0034571	Ovarian fibrosis
HP:0034572	Pigment incontinence
HP:0034573	Abnormal epidermal protein expression
HP:0034574	Reduced epidermal keratin 10 protein expression
HP:0034575	Reduced epidermal collagen IV protein expression
HP:0034576	Reduced epidermal bullous pemphigoid antigen 1 protein expression
HP:0034577	Reduced epidermal collagen VII protein expression
HP:0034578	Reduced epidermal collagen XVII protein expression
HP:0034579	Reduced epidermal integrin alpha6beta4 protein expression
HP:0034580	Reduced epidermal plectin protein expression
HP:0034581	Bloodstream Trypanosoma cruzi
HP:0034582	Abnormal lymph node cell composition
HP:0034583	Lipid-laden lymph node macrophages
HP:0034584	Abnormal pancreatic acinus morphology
HP:0034585	Cochlear nerve hypoplasia
HP:0034586	Glutathionuria
HP:0034587	Nevus psiloliparus
HP:0034588	Crypt hyperplasia
HP:0034589	Increased circulating dehydroepiandrosterone-sulfate concentration
HP:0034590	Abnormal circulating thyroxine-binding globulin concentration
HP:0034591	Decreased circulating thyroxine-binding globulin concentration
HP:0034592	Elevated circulating beta-aminoisobutyric acid concentration
HP:0034593	Elevated circulating dihydrouracil concentration
HP:0034594	Elevated circulating dihydrothymine concentration
HP:0034595	Elevated circulating N-carbamyl-beta-alanine concentration
HP:0034596	Elevated ciculating 5-hydroxymethyluracil concentration
HP:0034597	Decreased CSF creatinine concentration
HP:0034598	Elevated urinary creatine level
HP:0034599	Decreased circulating biotin concentration
HP:0034600	Elevated circulating thrombopoietin concentration
HP:0034601	Decreased circulating C1q concentration
HP:0034602	Decreased circulating apolipoprotein A-II concentration
HP:0034603	Elevated circulating CA19-9 concentration
HP:0034604	Elevated circulating DOPA concentration
HP:0034605	Elevated CSF DOPA concentration
HP:0034606	Elevated circulating porphyrin concentration
HP:0034607	Decreased circulating 17-hydroxyprogesterone concentration
HP:0034608	Decreased circulating transcobalamin II concentration
HP:0034609	Polychromasia
HP:0034610	Decreased circulating myo-inositol concentration
HP:0034611	Elevated circulating arabitol concentration
HP:0034612	Elevated urine arabitol level
HP:0034613	Elevated urine erythritol level
HP:0034614	Elevated circulating erythritol concentration
HP:0034615	Reduced circulating matrix metalloproteinase 2 concentration
HP:0034616	Abnormal circulating coenzyme concentration
HP:0034617	Elevated circulating S-adenosyl methionine concentration
HP:0034618	Abnormal ...

2023-01-27 Release

What's Changed

• Make sure the hp.json version is copied correctly into HPOA by @matentzn in #9566
• Return of the diff by @matentzn in #9600
• Prepare HPO release by @matentzn in #9602

New terms

term id	term label
HP:0034517	Pretibial hyperpigmentation
HP:0034518	Gingival fragility
HP:0034519	Muscle fiber fuchsinophilic inclusion bodies
HP:0034520	Esophageal myenteric plexus degeneration
HP:4000125	Recent honey ingestion
HP:4000124	High dietary oxalate intake
HP:4000127	Aggravated by sodium channel blocking agents
HP:4000126	Raw egg-white ingestion
HP:4000121	Triggered by poison ivy, poson oak, or sumac
HP:4000120	Triggered by nickel
HP:4000123	Nutrition history
HP:4000122	History of exclusive breast feeding
HP:4000117	Valproate exposure
HP:4000116	Carbamazepine exposure
HP:4000119	Calcium channel blocker exposure
HP:4000118	Hydralazine exposure
HP:4000113	Aminoglycoside exposure
HP:4000112	Medication history
HP:4000115	Potassium-sparing diuretic exposure
HP:4000114	Statin exposure
HP:4000109	Triggered by electromagnetic field
HP:4000108	Bone marrow erythroid vacuolization
HP:4000111	Asbestos exposure
HP:4000110	Exposure history
HP:4000105	Abnormal four chamber view of the fetal heart
HP:4000104	Curved dental root
HP:4000107	Positive lupus band test
HP:4000106	Spleen hamartoma
HP:4000101	Triggered by exposure to medication
HP:4000100	Positive lactose hydrogen breath test
HP:4000103	Ameliorated by oral zinc supplementation
HP:4000102	Triggered by allopurinol
HP:4000093	Ectopic tooth eruption
HP:4000095	Elevated circulating thymine concentration
HP:4000094	Corpus cavernosum hypoplasia
HP:4000160	Typified by low penetrance
HP:4000159	Typified by moderate penetrance
HP:4000158	Typified by high penetrance
HP:4000153	Cervical squamous cell papilloma
HP:4000152	Alternating laterality
HP:4000154	Liver leiomyoma
HP:4000149	Lymph node necrosis
HP:4000148	Portal artery hyperplasia
HP:4000151	History of recent cotralateral injury
HP:4000150	Multinucleated neuron
HP:4000145	History of recent viral illness
HP:4000144	Recent past medical history
HP:4000147	Abnormal portal artery morphology
HP:4000146	History of recent dental procedure
HP:4000141	Left ventricular dilatation
HP:4000140	Fetal bowel dilatation
HP:4000143	Abnormal fetal heart outflow tract
HP:4000142	Fetal trigonocephaly
HP:4000137	Isoniazid exposure
HP:4000136	6-mercaptopurine exposure
HP:4000139	Fetal abdominal cyst
HP:4000138	Absent cavum septum pellucidum
HP:4000133	Triggered by angiotensin-converting enzyme inhibitor
HP:4000132	Aggravated by phenytoin
HP:4000135	5-fluorouracil exposure
HP:4000134	Prostaglandin E1 exposure
HP:4000129	Recent blood transfusion
HP:4000128	Nitric oxide addiction
HP:4000131	Ameliorated by vitamin D
HP:4000130	Ameliorated by colchicine

Full Changelog: v2022-12-15...v2022-01-27