Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

How to imputate chrX using GLIMPSE2 #218

Open
raksasa opened this issue Jul 10, 2024 · 1 comment
Open

How to imputate chrX using GLIMPSE2 #218

raksasa opened this issue Jul 10, 2024 · 1 comment

Comments

@raksasa
Copy link

raksasa commented Jul 10, 2024

Hi,
I am trying to imputate chrX using GLIMPSE2, but not like GLIMPSE1, I found that there is no tutorial for chrX. I think the GLIMPSE1 workflow process chrX different to autosomal when preparing referenc panel (when calculating GL, the ploidy is setup by bcftools), while GLIMPSE2 do not document such step, and no ploidy parameters found in GLMPSE2_phase. Then what should I do if i am using BAM as input? or something I have misunderstoold?

thanks in advance~

@salim0mans
Copy link

Hi,
The authors indeed have a tutorial for Glimpse chrX imputation, but it's in Glimpse1 site:
https://odelaneau.github.io/GLIMPSE/glimpse1/tutorial_chrX.html
I believe the commands and flags are basically the same for Glimpse2.
The ploidy-related flag is --samples-file

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

2 participants