Highlights
- Multi-omics analysis identified TGF-β1–SMAD4 as key regulators in human skin aging
- THBS1 promoted and FMOD suppressed factors in skin aging
- THBS1 controlled high- and low-TGF-β1 state of the binary switch
- SMAD4 is a potential target for inhibiting THBS1 expression and cell senescence
$ git clone https://github.com/okadalabipr/Haga2023.git
bifurcation_analysis/: bifurcation analysis of TGF-β1, THBS1, and FMOD networkbioinformatics/: sequencing data analysisfigure/: graphical abstractmodeling/: mathematical modeling of TGF-β and VEGF signaling pathway dynamics on skin aging
MIT