Postpone Meeting Today (December 10th 2021)

[mattodd]

Hi all,

Today's no good for me, sorry.

Current active things, following #103

• @QSimpson to update on whether shipment is incoming. Last day Paul can do the assay is Wednesday Dec 15th, so they'd need to be at UCL by the 14th.
• Lee Graves is sending data through after last week's meeting. I'll post when we get it. We were interested in a subtraction plot of experiment minus control, to reveal differences. Lee is also chasing getting the MRSA experiments done.
• Lee asked whether we'd ever gotten these compounds tested vs a kinase panel. Can someone check? I may need to go back to @TwistedSwisster if we dont know.
• Compounds for ADME in ADME data - Dec 2021 #104 have, I think, arrived at NEU and will be shipped out. This reduces the need for eval at Sue Charman's lab, but we do have funds for one in vivo PK evaluation, if we think that this is justified. I'm torn.
• @danaklug will share a paper draft ASAP.

Anything else? Hope everyone is nonomicron.

(I notice in passing that there is now a "Discussions" function on Github (look above) that might be useful, can't tell).

[QSimpson]

Hi All, sorry for the delay. Our next shipment is ready pending final QC checks leaving Boston on the 15th of December. I'll post a chemdraw shortly of the compounds being shipped.

[danaklug]

A link to the paper draft has been posted in #101 - I'll continue to work on it but please do have a look. Anyone can edit or add comments and all feedback and additions are welcome!

[QSimpson]

The following will be sent on the 15th. In addition we will also send ~70 mg of N-(4-fluorophenyl)-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine as requested by @danaklug

[danaklug]

Amazing, thanks @QSimpson!

[mattodd]

Awesome @QSimpson. This just misses the window for eval before Xmas, but @edwintse are you happy to ensure the samples are freezer-ed for evaluation in the new year?

[edwintse]

Yes, I'll make sure the samples are stored over the break

[danaklug]

Compounds have been given OSA IDs and added to the master sheet.