DAllPhin-AtoM v0.9.1

Release Notes

1. User Interface of Elimination tab was redesigned.
2. Elimination Tab: Fh is calculated automatically using CL_h,int according to the dispersion model.
3. Minor bugs (weight units of animal species, units of plot axis, etc) were corrected.
4. The equation used internally to calculate CL_perm in the Fg prediction step was revised.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DAllPhin-AtoM v0.9.0

Release note (0.9.0)

1. The completely redesigned user interface (UI) and new features are introduced.
2. Concentration Prediction tab: The simulation speed for concentration prediction has been substantially improved by adopting the mrgsolve R package.
3. Full PBPK tab: The new feature implementing the simulation of plasma and tissue concentration profiles using a full PBPK model is available.
4. The PBPK approach in the Distribution tab: The predicted human tissue distribution (Kp) values in various tissues instead of Vss values are presented to the user.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DAllPhin-AtoM 0.8.9 ver

Release note (0.8.9)

1. Allometric approach in the Elimination tab: the unit of CL (L/hr) was corrected to “L/hr/kg”, and the same unit was marked in the "Allometric scaling result" box.
2. Allometric approach in the Distribution tab and the Elimination tab: When the brain weight (bw) or maximum life span (mlp) was chosen, the errors of omitting bw and mlp at the final calculation formulas for Q and CL were corrected.
3. “Hepatocyte” in the “in vitro/in vivo” option of the Elimination tab: the title of the fraction “Vcell/Vincubation” was corrected to “Ncell/Vincubation”.
4. The human body weight fixed to 70 kg was revised so that the user may choose between 60 and 70 kg.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

Dallphin-AtoM 0.8.8

Release note (0.8.8)

1. Elimination tab: The error in the body weight unit at the allometric CL prediction step was fixed.
2. Final Parameter tab: The error in the display of Vss for a 1 compartment model was fixed.
3. Distribution tab: The error in using the brain weight and MLP at the allometric Q prediction
   step was fixed.
4. Distribution tab: At the allometric 1 compartment model, the ka and Fa_Caco are automatically given like in the case of the 2 compartment model.
5. JRE (Java Runtime Environment) was changed from the Oracle JRE to the open JRE.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

Dallphin-AtoM 0.8.7

Drugs with allometry and Physiology inside - Animal to Human

Release note (0.8.7)

1. Qgut model was included to predict the intestinal bioavailability (Fg)
2. Allometric calculation methods of CL was added.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050