Normalization method for whole exome data

[seunghun23]

Hi,

I am trying to run deconstructSigs using both v2 and v3 of COSMIC signatures and wonder what's the best option to use for "tri.counts.method" in each case.

I've tried following and wanted to make sure that this is the correct methods to use

For v2 - signatures.ref=signatures.cosmic , tri.counts.method="exome"
For v3 - signatures.ref=signatures.exome.cosmic.v3.may2019 , tri.counts.method="exome"

Thank you for your help in advance