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deconstructSig usage #7
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Hi Oliver, best, |
Hi Oliver, |
I actually haven’t — and didn’t spot that contradictory information Ouch.
We’ll be comparing the deconstructSig calls vs a set of around 300 PDACs in the next 2 months or so. Can provide an update at that point. Alternatively, new signatures are being presented just now at ICGG in Seoul which should be released in the next month; might make sense to wait for the next round of tools.
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Thanks, at least I'll notifiy the deconstructSigs authors about the contradictory info. |
Analysis of mutational signatures in PCGR 0.4.0 is made more configurable (user can specify trimer normalization and number of signatures in search space) |
Hi,
done some more testing and seem to be running into odd mutational signatures that I did not expect. It seems that PCGR defaults to exome data (tri.counts.method = 'exome') which might be causing problems with WGS results. Any chance of making this configurable?
Best, Oliver
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