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Generalise the alignment score to one peptide against a set of germlines #24

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douweschulte opened this issue Mar 11, 2024 · 0 comments
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A-align Area: rustyms-align

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@douweschulte
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If you align one peptide against multiple germlines it is nice to have a way of determining which alignments are interesting. If this peptide can reasonably be assumed to come from one germline, it shares too much with a subset, or it does not match any at all.

Older thoughts: 1 score per germline for how likely to be enriched, taking into account that germlines can be distanced heterogeneously, that peptides can match incorrectly and the peptides can be plain wrong.
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When this abs score is normalised by the number of peptides it gives a feeling on how well peptides support this specific germline. Alternatively when normalised on the maximal absolute germline score it gives a feeling on the absolute number of support (and with that the number of peptides).

@douweschulte douweschulte added the A-align Area: rustyms-align label Mar 11, 2024
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