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clean_data_all_level.json
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[
{
"id": "R-HSA-1640170",
"label": "Cell Cycle",
"weight": 739.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1640170",
"groups": [
{
"id": "R-HSA-1500620",
"label": "Meiosis",
"weight": 89.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1500620",
"groups": [
{
"id": "R-HSA-1221632",
"label": "Meiotic synapsis",
"weight": 60.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1221632"
},
{
"id": "R-HSA-912446",
"label": "Meiotic recombination",
"weight": 57.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912446"
}
]
},
{
"id": "R-HSA-69278",
"label": "Cell Cycle, Mitotic",
"weight": 574.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69278",
"groups": [
{
"id": "R-HSA-453274",
"label": "Mitotic G2-G2/M phases",
"weight": 205.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-453274",
"groups": [
{
"id": "R-HSA-68911",
"label": "G2 Phase",
"weight": 5.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68911"
},
{
"id": "R-HSA-69275",
"label": "G2/M Transition",
"weight": 203.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69275",
"groups": [
{
"id": "R-HSA-156711",
"label": "Polo-like kinase mediated events",
"weight": 16.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156711"
},
{
"id": "R-HSA-2565942",
"label": "Regulation of PLK1 Activity at G2/M Transition",
"weight": 87.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2565942"
},
{
"id": "R-HSA-380287",
"label": "Centrosome maturation",
"weight": 81.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380287",
"groups": [
{
"id": "R-HSA-380270",
"label": "Recruitment of mitotic centrosome proteins and complexes",
"weight": 81.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380270"
},
{
"id": "R-HSA-380284",
"label": "Loss of proteins required for interphase microtubule organization from the centrosome",
"weight": 69.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380284",
"groups": [
{
"id": "R-HSA-380259",
"label": "Loss of Nlp from mitotic centrosomes",
"weight": 69.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380259"
}
]
}
]
},
{
"id": "R-HSA-69273",
"label": "Cyclin A/B1/B2 associated events during G2/M transition",
"weight": 30.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69273",
"groups": [
{
"id": "R-HSA-170145",
"label": "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes",
"weight": 3.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170145"
}
]
},
{
"id": "R-HSA-8852276",
"label": "The role of GTSE1 in G2/M progression after G2 checkpoint",
"weight": 79.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8852276"
},
{
"id": "R-HSA-8854050",
"label": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis",
"weight": 55.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854050"
},
{
"id": "R-HSA-8854518",
"label": "AURKA Activation by TPX2",
"weight": 72.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854518"
},
{
"id": "R-HSA-8854521",
"label": "Interaction between PHLDA1 and AURKA",
"weight": 2.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854521"
}
]
}
]
},
{
"id": "R-HSA-453276",
"label": "Regulation of mitotic cell cycle",
"weight": 86.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-453276",
"groups": [
{
"id": "R-HSA-174143",
"label": "APC/C-mediated degradation of cell cycle proteins",
"weight": 86.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174143",
"groups": [
{
"id": "R-HSA-174084",
"label": "Autodegradation of Cdh1 by Cdh1:APC/C",
"weight": 63.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174084"
},
{
"id": "R-HSA-174178",
"label": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1",
"weight": 72.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174178"
},
{
"id": "R-HSA-176407",
"label": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase",
"weight": 19.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176407"
},
{
"id": "R-HSA-176408",
"label": "Regulation of APC/C activators between G1/S and early anaphase",
"weight": 80.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176408",
"groups": [
{
"id": "R-HSA-141405",
"label": "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components",
"weight": 20.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141405",
"groups": [
{
"id": "R-HSA-141430",
"label": "Inactivation of APC/C via direct inhibition of the APC/C complex",
"weight": 20.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141430"
}
]
},
{
"id": "R-HSA-174113",
"label": "SCF-beta-TrCP mediated degradation of Emi1",
"weight": 55.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174113"
},
{
"id": "R-HSA-176417",
"label": "Phosphorylation of Emi1",
"weight": 6.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176417"
}
]
},
{
"id": "R-HSA-176814",
"label": "Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins",
"weight": 76.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176814",
"groups": [
{
"id": "R-HSA-176409",
"label": "APC/C:Cdc20 mediated degradation of mitotic proteins",
"weight": 75.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176409",
"groups": [
{
"id": "R-HSA-174048",
"label": "APC/C:Cdc20 mediated degradation of Cyclin B",
"weight": 23.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174048"
},
{
"id": "R-HSA-174154",
"label": "APC/C:Cdc20 mediated degradation of Securin",
"weight": 67.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174154"
},
{
"id": "R-HSA-179419",
"label": "APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",
"weight": 73.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-179419",
"groups": [
{
"id": "R-HSA-174184",
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174184",
"label": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A",
"weight": 72.0
},
{
"id": "R-HSA-179409",
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-179409",
"label": "APC-Cdc20 mediated degradation of Nek2A",
"weight": 25.0
}
]
}
]
},
{
"id": "R-HSA-176412",
"label": "Phosphorylation of the APC/C",
"weight": 19.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176412"
}
]
}
]
}
]
},
{
"id": "R-HSA-453279",
"label": "Mitotic G1-G1/S phases",
"weight": 171.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-453279",
"groups": [
{
"id": "R-HSA-1538133",
"label": "G0 and Early G1",
"weight": 41.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1538133",
"groups": [
{
"id": "R-HSA-1362277",
"label": "Transcription of E2F targets under negative control by DREAM complex",
"weight": 31.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1362277"
},
{
"id": "R-HSA-1362300",
"label": "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1",
"weight": 16.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1362300"
}
]
},
{
"id": "R-HSA-69206",
"label": "G1/S Transition",
"weight": 145.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69206",
"groups": [
{
"id": "R-HSA-113510",
"label": "E2F mediated regulation of DNA replication",
"weight": 23.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113510",
"groups": [
{
"id": "R-HSA-113501",
"label": "Inhibition of replication initiation of damaged DNA by RB1/E2F1",
"weight": 14.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113501"
},
{
"id": "R-HSA-113507",
"label": "E2F-enabled inhibition of pre-replication complex formation",
"weight": 9.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113507"
}
]
},
{
"id": "R-HSA-68962",
"label": "Activation of the pre-replicative complex",
"weight": 33.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68962"
},
{
"id": "R-HSA-69202",
"label": "Cyclin E associated events during G1/S transition ",
"weight": 83.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69202",
"groups": [
{
"id": "R-HSA-187577",
"label": "SCF(Skp2)-mediated degradation of p27/p21",
"weight": 60.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187577"
},
{
"id": "R-HSA-69200",
"label": "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes",
"weight": 4.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69200"
}
]
},
{
"id": "R-HSA-69205",
"label": "G1/S-Specific Transcription",
"weight": 34.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69205",
"groups": [
{
"id": "R-HSA-539107",
"label": "Activation of E2F1 target genes at G1/S",
"weight": 34.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-539107"
}
]
}
]
},
{
"id": "R-HSA-69236",
"label": "G1 Phase",
"weight": 44.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69236",
"groups": [
{
"id": "R-HSA-69231",
"label": "Cyclin D associated events in G1",
"weight": 44.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69231"
}
]
}
]
},
{
"id": "R-HSA-68886",
"label": "M Phase",
"weight": 391.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68886",
"groups": [
{
"id": "R-HSA-2555396",
"label": "Mitotic Metaphase and Anaphase",
"weight": 203.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2555396",
"groups": [
{
"id": "R-HSA-68881",
"label": "Mitotic Metaphase/Anaphase Transition",
"weight": 2.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68881"
},
{
"id": "R-HSA-68882",
"label": "Mitotic Anaphase",
"weight": 202.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68882",
"groups": [
{
"id": "R-HSA-2467813",
"label": "Separation of Sister Chromatids",
"weight": 190.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2467813"
},
{
"id": "R-HSA-2995410",
"label": "Nuclear Envelope Reassembly",
"weight": 14.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2995410",
"groups": [
{
"id": "R-HSA-2995383",
"label": "Initiation of Nuclear Envelope Reformation",
"weight": 14.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2995383"
}
]
}
]
}
]
},
{
"id": "R-HSA-68875",
"label": "Mitotic Prophase",
"weight": 128.0,
"url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68875",
"groups": [
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"id": "R-HSA-162658",
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