weights=np.array([x0.shape[0] / (x0.shape[0] + x1.shape[0]), ZeroDivisionError: division by zero

[eynullazada]

Hi

I am trying to apply diffxpy to my data which has about 300 cells on rows and about 17k genes on columns. I have two predefined clusters. When I try to run I get that error message. I have removed columns with all zero values from the matrix.

Error Message:

• loading matrix: test_mat.txt
• cl1
  /mnt/ws/home/keynullazada/.conda/envs/p_env/lib/python3.7/site-packages/numpy/core/fromnumeric.py:3257: RuntimeWarning: Mean of empty slice.
  out=out, **kwargs)
  /mnt/ws/home/keynullazada/.conda/envs/p_env/lib/python3.7/site-packages/numpy/core/_methods.py:154: RuntimeWarning: invalid value encountered in true_divide
  ret, rcount, out=ret, casting='unsafe', subok=False)
  Traceback (most recent call last):
  File "/mnt/dv/wid/projects5/Roy-singlecell/js_work/scripts/DEG_listing/diffxpy_ttest_DEG_listing.py", line 30, in
  grouping="condition"
  File "/mnt/dv/wid/projects5/Roy-singlecell/sridharanlab/data/perturb-seq/ke_work/scRNAseqalone_KE_custom/submatrices/diffxpy_DEG/batchglm/diffxpy/diffxpy/testing/tests.py", line 860, in t_test
  is_sig_zerovar=is_sig_zerovar
  File "/mnt/dv/wid/projects5/Roy-singlecell/sridharanlab/data/perturb-seq/ke_work/scRNAseqalone_KE_custom/submatrices/diffxpy_DEG/batchglm/diffxpy/diffxpy/testing/det.py", line 1572, in init
  weights=np.array([x0.shape[0] / (x0.shape[0] + x1.shape[0]),
  ZeroDivisionError: division by zero

looking forward to hearing from you

Khagani