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A question about general mode in logistic mode #89
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Hi @shangguandong1996, great question! There are two possibilities:
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Thanks for your reply :) Actually, I am interested in plants . According to the
Is it mean that all TF will share same parameter(or I can say weight) about motif, ATAC-Seq, H3K27ac ? Please forgive me if I misunderstand something :) Guandong Shang |
Hi, deal developer
I have a question about general mode when traing logistic mode. In my thinking, the TF-specific mode is based on 237 TFs from REMAP. I take TF A as a example.
The 1 represent TF A ChIP-Seq bind in databse, 0 represent other TF bind in other peak in all enhancer peak stie. So using logistic mode will produce TF-A specific β parameters for motif zscore, socore of ATAC, H3K27ac, ChIP. Then I can predict probabilty of TF-A binding in my enhacer site using above paramter.
But If I just have motif databse in other species other than human or mouse, how can I train mode using logistic mode. After all, I have no training data. I noticed you have offer general mode for this condition, but I am confused the theory behind.
Best wishes
Guandong Shang
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