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biolink-model.owl.ttl
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@prefix AGRKB: <https://www.alliancegenome.org/> .
@prefix CHADO: <http://gmod.org/wiki/Chado/> .
@prefix CHEMBL.MECHANISM: <https://www.ebi.ac.uk/chembl/mechanism/inspect/> .
@prefix CPT: <https://www.ama-assn.org/practice-management/cpt/> .
@prefix CTD: <http://ctdbase.org/> .
@prefix DGIdb: <https://www.dgidb.org/interaction_types> .
@prefix DOID-PROPERTY: <http://purl.obolibrary.org/obo/doid#> .
@prefix DrugCentral: <http://drugcentral.org/drugcard/> .
@prefix ECTO: <http://purl.obolibrary.org/obo/ECTO_> .
@prefix EDAM-DATA: <http://edamontology.org/data_> .
@prefix EFO: <http://www.ebi.ac.uk/efo/EFO_> .
@prefix ExO: <http://purl.obolibrary.org/obo/ExO_> .
@prefix FYPO: <http://purl.obolibrary.org/obo/FYPO_> .
@prefix GOP: <http://purl.obolibrary.org/obo/go#> .
@prefix GOREL: <http://purl.obolibrary.org/obo/GOREL_> .
@prefix HANCESTRO: <http://www.ebi.ac.uk/ancestro/ancestro_> .
@prefix HCPCS: <http://purl.bioontology.org/ontology/HCPCS/> .
@prefix HsapDv: <http://purl.obolibrary.org/obo/HsapDv_> .
@prefix IAO: <http://purl.obolibrary.org/obo/IAO_> .
@prefix INO: <http://purl.obolibrary.org/obo/INO_> .
@prefix LOINC: <http://loinc.org/rdf/> .
@prefix MAXO: <http://purl.obolibrary.org/obo/MAXO_> .
@prefix MESH: <http://id.nlm.nih.gov/mesh/> .
@prefix MI: <http://purl.obolibrary.org/obo/MI_> .
@prefix NBO-PROPERTY: <http://purl.obolibrary.org/obo/nbo#> .
@prefix NCIT-OBO: <http://purl.obolibrary.org/obo/ncit#> .
@prefix NDDF: <http://purl.bioontology.org/ontology/NDDF/> .
@prefix OBAN: <http://purl.org/oban/> .
@prefix OIO: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix PHAROS: <http://pharos.nih.gov> .
@prefix PathWhiz: <http://smpdb.ca/pathways/#> .
@prefix REPODB: <http://apps.chiragjpgroup.org/repoDB/> .
@prefix RO: <http://purl.obolibrary.org/obo/RO_> .
@prefix RXNORM: <http://purl.bioontology.org/ontology/RXNORM/> .
@prefix SEMMEDDB: <https://skr3.nlm.nih.gov/SemMedDB> .
@prefix SIO: <http://semanticscience.org/resource/SIO_> .
@prefix SNOMEDCT: <http://snomed.info/id/> .
@prefix STY: <http://purl.bioontology.org/ontology/STY/> .
@prefix UBERGRAPH: <http://translator.renci.org/ubergraph-axioms.ofn#> .
@prefix UBERON_CORE: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix UBERON_NONAMESPACE: <http://purl.obolibrary.org/obo/core#> .
@prefix UMLSSG: <https://lhncbc.nlm.nih.gov/semanticnetwork/download/sg_archive/SemGroups-v04.txt> .
@prefix UO-PROPERTY: <http://purl.obolibrary.org/obo/uo#> .
@prefix VANDF: <https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF/> .
@prefix VMC: <https://github.com/ga4gh/vr-spec/> .
@prefix WBVocab: <http://bio2rdf.org/wormbase_vocabulary> .
@prefix WBbt: <http://purl.obolibrary.org/obo/WBbt_> .
@prefix WIKIDATA: <https://www.wikidata.org/entity/> .
@prefix WIKIDATA_PROPERTY: <https://www.wikidata.org/prop/> .
@prefix XPO: <http://purl.obolibrary.org/obo/XPO_> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix bioschemas: <https://bioschemas.org/> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dcid: <https://datacommons.org/browser/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix gff3: <https://github.com/The-Sequence-Ontology/Specifications/blob/master/gff3.md#> .
@prefix gpi: <https://github.com/geneontology/go-annotation/blob/master/specs/gpad-gpi-2-0.md#> .
@prefix linkml: <https://w3id.org/linkml/> .
@prefix orphanet: <http://www.orpha.net/ORDO/Orphanet_> .
@prefix os: <https://github.com/cmungall/owlstar/blob/master/owlstar.ttl> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix qud: <http://qudt.org/1.1/schema/qudt#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix schema: <http://schema.org/> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix wgs: <http://www.w3.org/2003/01/geo/wgs84_pos> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
<https://w3id.org/biolink/biolink-model.owl.ttl> a owl:Ontology ;
rdfs:label "Biolink-Model" ;
IAO:0000700 biolink:Annotation,
biolink:CaseToEntityAssociationMixin,
biolink:CellLineToEntityAssociationMixin,
biolink:ChemicalEntityOrGeneOrGeneProduct,
biolink:ChemicalEntityOrProteinOrPolypeptide,
biolink:ChemicalEntityToEntityAssociationMixin,
biolink:ChemicalOrDrugOrTreatment,
biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin,
biolink:DiseaseToEntityAssociationMixin,
biolink:Entity,
biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin,
biolink:EntityToExposureEventAssociationMixin,
biolink:EntityToOutcomeAssociationMixin,
biolink:EpigenomicEntity,
biolink:FrequencyQualifierMixin,
biolink:GeneExpressionMixin,
biolink:GeneGroupingMixin,
biolink:GeneToEntityAssociationMixin,
biolink:GenomicEntity,
biolink:GenotypeToEntityAssociationMixin,
biolink:InformationResourceCollection,
biolink:MacromolecularMachineMixin,
biolink:MacromolecularMachineToEntityAssociationMixin,
biolink:MappingCollection,
biolink:MaterialSampleToEntityAssociationMixin,
biolink:ModelToDiseaseAssociationMixin,
biolink:OntologyClass,
biolink:OrganismTaxonToEntityAssociation,
biolink:Outcome,
biolink:PathologicalEntityMixin,
biolink:PhysicalEssenceOrOccurrent,
biolink:PredicateMapping,
biolink:RelationshipQuantifier,
biolink:SubjectOfInvestigation,
biolink:ThingWithTaxon,
biolink:VariantToEntityAssociationMixin ;
dct:license "https://creativecommons.org/publicdomain/zero/1.0/" ;
pav:version "3.3.2" ;
linkml:generation_date "2023-05-04T23:01:41" ;
linkml:metamodel_version "1.7.0" ;
linkml:source_file "biolink-model.yaml" ;
linkml:source_file_date "2023-05-04T23:00:24" ;
linkml:source_file_size 355095 .
biolink:AccessibleDnaRegion a owl:Class ;
rdfs:label "accessible dna region" ;
rdfs:subClassOf biolink:ChemicalEntityOrGeneOrGeneProduct,
biolink:GenomicEntity,
biolink:OntologyClass,
biolink:PhysicalEssence,
biolink:RegulatoryRegion ;
skos:altLabel "atac-seq accessible region",
"dnase-seq accessible region" ;
skos:definition "A region (or regions) of a chromatinized genome that has been measured to be more accessible to an enzyme such as DNase-I or Tn5 Transpose" ;
skos:exactMatch <http://purl.obolibrary.org/obo/SO_0002231> .
biolink:AnatomicalEntityToAnatomicalEntityOntogenicAssociation a owl:Class ;
rdfs:label "anatomical entity to anatomical entity ontogenic association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
skos:definition "A relationship between two anatomical entities where the relationship is ontogenic, i.e. the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship." .
biolink:AnatomicalEntityToAnatomicalEntityPartOfAssociation a owl:Class ;
rdfs:label "anatomical entity to anatomical entity part of association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
biolink:AnatomicalEntityToAnatomicalEntityAssociation ;
skos:definition "A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms" .
biolink:Bacterium a owl:Class ;
rdfs:label "bacterium" ;
rdfs:subClassOf biolink:OrganismalEntity ;
skos:definition "A member of a group of unicellular microorganisms lacking a nuclear membrane, that reproduce by binary fission and are often motile." ;
skos:exactMatch STY:T007,
<http://purl.obolibrary.org/obo/NCBITaxon_1869227> .
biolink:BehaviorToBehavioralFeatureAssociation a owl:Class ;
rdfs:label "behavior to behavioral feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_count ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:Behavior ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:BehavioralFeature ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_total ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:BiologicalSex ;
owl:onProperty biolink:sex_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_quotient ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_percentage ],
biolink:Association,
biolink:EntityToPhenotypicFeatureAssociationMixin ;
skos:definition "An association between an mixture behavior and a behavioral feature manifested by the individual exhibited or has exhibited the behavior." .
biolink:BehavioralExposure a owl:Class ;
rdfs:label "behavioral exposure" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:TimeType ;
owl:onProperty biolink:timepoint ],
biolink:Attribute,
biolink:ExposureEvent ;
skos:definition "A behavioral exposure is a factor relating to behavior impacting an individual." .
biolink:BehavioralOutcome a owl:Class ;
rdfs:label "behavioral outcome" ;
rdfs:subClassOf biolink:Outcome ;
skos:definition "An outcome resulting from an exposure event which is the manifestation of human behavior." .
biolink:BioticExposure a owl:Class ;
rdfs:label "biotic exposure" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:TimeType ;
owl:onProperty biolink:timepoint ],
biolink:Attribute,
biolink:ExposureEvent ;
skos:altLabel "bacterial exposure",
"viral exposure" ;
skos:definition "An external biotic exposure is an intake of (sometimes pathological) biological organisms (including viruses)." .
biolink:Book a owl:Class ;
rdfs:label "book" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:allValuesFrom linkml:String ;
owl:onProperty rdf:type ],
[ a owl:Restriction ;
owl:onClass linkml:String ;
owl:onProperty biolink:id ;
owl:qualifiedCardinality 1 ],
biolink:Publication ;
skos:definition "This class may rarely be instantiated except if use cases of a given knowledge graph support its utility." .
biolink:CaseToPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "case to phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_quotient ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:BiologicalSex ;
owl:onProperty biolink:sex_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_total ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_percentage ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_count ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
biolink:Association,
biolink:CaseToEntityAssociationMixin,
biolink:EntityToPhenotypicFeatureAssociationMixin ;
skos:definition "An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype." .
biolink:Cell a owl:Class ;
rdfs:label "cell" ;
rdfs:subClassOf biolink:AnatomicalEntity ;
skos:exactMatch MESH:D002477,
STY:T025,
<http://purl.obolibrary.org/obo/CL_0000000>,
<http://purl.obolibrary.org/obo/GO_0005623>,
SIO:010001,
WIKIDATA:Q7868 .
biolink:CellLineAsAModelOfDiseaseAssociation a owl:Class ;
rdfs:label "cell line as a model of disease association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:CellLine ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
biolink:CellLineToDiseaseOrPhenotypicFeatureAssociation,
biolink:EntityToDiseaseAssociationMixin,
biolink:ModelToDiseaseAssociationMixin .
biolink:ChemicalAffectsGeneAssociation a owl:Class ;
rdfs:label "chemical affects gene association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:ChemicalEntityDerivativeEnum ;
owl:onProperty biolink:subject_derivative_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
owl:onProperty biolink:subject_part_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:DirectionQualifierEnum ;
owl:onProperty biolink:object_direction_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
owl:onProperty biolink:subject_form_or_variant_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:ChemicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:OrganismTaxon ;
owl:onProperty biolink:species_context_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
owl:onProperty biolink:object_aspect_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty biolink:subject_context_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:String ;
owl:onProperty biolink:qualified_predicate ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
owl:onProperty biolink:object_part_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty biolink:object_context_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
owl:onProperty biolink:object_form_or_variant_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
owl:onProperty biolink:subject_aspect_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:CausalMechanismQualifierEnum ;
owl:onProperty biolink:causal_mechanism_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty biolink:anatomical_context_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:DirectionQualifierEnum ;
owl:onProperty biolink:subject_direction_qualifier ],
biolink:Association ;
skos:definition "Describes an effect that a chemical has on a gene or gene product (e.g. an impact of on its abundance, activity, localization, processing, expression, etc.)" .
biolink:ChemicalEntityAssessesNamedThingAssociation a owl:Class ;
rdfs:label "chemical entity assesses named thing association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:NamedThing ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:ChemicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
biolink:Association .
biolink:ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation a owl:Class ;
rdfs:label "chemical entity or gene or gene product regulates gene association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:ChemicalEntityOrGeneOrGeneProduct ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:DirectionQualifierEnum ;
owl:onProperty biolink:object_direction_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
biolink:Association ;
skos:definition "A regulatory relationship between two genes" .
biolink:ChemicalGeneInteractionAssociation a owl:Class ;
rdfs:label "chemical gene interaction association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty biolink:anatomical_context_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
owl:onProperty biolink:subject_form_or_variant_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
owl:onProperty biolink:subject_part_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty biolink:object_context_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty biolink:subject_context_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:ChemicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:ChemicalEntityDerivativeEnum ;
owl:onProperty biolink:subject_derivative_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalPartQualifierEnum ;
owl:onProperty biolink:object_part_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:ChemicalOrGeneOrGeneProductFormOrVariantEnum ;
owl:onProperty biolink:object_form_or_variant_qualifier ],
biolink:Association,
biolink:ChemicalToEntityAssociationMixin ;
skos:definition "describes a physical interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)" ;
skos:exactMatch SIO:001257 .
biolink:ChemicalOrDrugOrTreatmentSideEffectDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "chemical or drug or treatment side effect disease or phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
biolink:ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation,
biolink:ChemicalToEntityAssociationMixin,
biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
skos:definition "This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disesae or phenotypic feature is a secondary, typically (but not always) undesirable effect." .
biolink:ChemicalToChemicalDerivationAssociation a owl:Class ;
rdfs:label "chemical to chemical derivation association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:ChemicalEntity ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:ChemicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:allValuesFrom biolink:MacromolecularMachineMixin ;
owl:onProperty biolink:catalyst_qualifier ],
biolink:ChemicalToChemicalAssociation ;
skos:definition """A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
IF
R has-input C1 AND
R has-output C2 AND
R enabled-by P AND
R type Reaction
THEN
C1 derives-into C2 <<catalyst qualifier P>>""" .
biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "chemical to disease or phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:DiseaseOrPhenotypicFeature ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
biolink:Association,
biolink:ChemicalToEntityAssociationMixin,
biolink:EntityToDiseaseOrPhenotypicFeatureAssociationMixin ;
skos:definition "An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype." ;
skos:narrowMatch SIO:000993 .
biolink:ChemicalToPathwayAssociation a owl:Class ;
rdfs:label "chemical to pathway association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:Pathway ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:ChemicalEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
biolink:Association,
biolink:ChemicalToEntityAssociationMixin ;
skos:definition "An interaction between a chemical entity and a biological process or pathway." ;
skos:exactMatch SIO:001250 .
biolink:ChiSquaredAnalysisResult a owl:Class ;
rdfs:label "chi squared analysis result" ;
rdfs:subClassOf biolink:StudyResult ;
skos:definition "A result of a chi squared analysis." .
biolink:ClinicalFinding a owl:Class ;
rdfs:label "clinical finding" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:allValuesFrom biolink:ClinicalAttribute ;
owl:onProperty biolink:has_attribute ],
biolink:PhenotypicFeature ;
skos:definition "this category is currently considered broad enough to tag clinical lab measurements and other biological attributes taken as 'clinical traits' with some statistical score, for example, a p value in genetic associations." .
biolink:ClinicalMeasurement a owl:Class ;
rdfs:label "clinical measurement" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:OntologyClass ;
owl:onProperty biolink:has_attribute_type ;
owl:qualifiedCardinality 1 ],
biolink:ClinicalAttribute ;
skos:definition "A clinical measurement is a special kind of attribute which results from a laboratory observation from a subject individual or sample. Measurements can be connected to their subject by the 'has attribute' slot." ;
skos:exactMatch EFO:0001444 .
biolink:ClinicalTrial a owl:Class ;
rdfs:label "clinical trial" ;
rdfs:subClassOf biolink:ClinicalEntity .
biolink:Cohort a owl:Class ;
rdfs:label "cohort" ;
rdfs:subClassOf biolink:StudyPopulation,
biolink:SubjectOfInvestigation ;
skos:definition "A group of people banded together or treated as a group who share common characteristics. A cohort 'study' is a particular form of longitudinal study that samples a cohort, performing a cross-section at intervals through time." ;
skos:exactMatch WIKIDATA:Q1303415 ;
skos:narrowMatch STY:T097,
STY:T099,
STY:T100,
STY:T101 .
biolink:CommonDataElement a owl:Class ;
rdfs:label "common data element" ;
rdfs:subClassOf biolink:InformationContentEntity ;
skos:closeMatch <http://purl.obolibrary.org/obo/NCIT_C19984> ;
skos:definition "A Common Data Element (CDE) is a standardized, precisely defined question, paired with a set of allowable responses, used systematically across different sites, studies, or clinical trials to ensure consistent data collection. Multiple CDEs (from one or more Collections) can be curated into Forms. (https://cde.nlm.nih.gov/home)" .
biolink:ComplexChemicalExposure a owl:Class ;
rdfs:label "complex chemical exposure" ;
rdfs:subClassOf biolink:Attribute ;
skos:definition "A complex chemical exposure is an intake of a chemical mixture (e.g. gasoline), other than a drug." .
biolink:ComplexMolecularMixture a owl:Class ;
rdfs:label "complex molecular mixture" ;
rdfs:subClassOf biolink:ChemicalMixture ;
skos:definition "A complex molecular mixture is a chemical mixture composed of two or more molecular entities with unknown concentration and stoichiometry." .
biolink:ConceptCountAnalysisResult a owl:Class ;
rdfs:label "concept count analysis result" ;
rdfs:subClassOf biolink:StudyResult ;
skos:definition "A result of a concept count analysis." .
biolink:ContributorAssociation a owl:Class ;
rdfs:label "contributor association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:allValuesFrom biolink:OntologyClass ;
owl:onProperty biolink:qualifiers ],
[ a owl:Restriction ;
owl:onClass biolink:InformationContentEntity ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:Agent ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
biolink:Association ;
skos:definition "Any association between an entity (such as a publication) and various agents that contribute to its realisation" .
biolink:DiseaseOrPhenotypicFeatureExposure a owl:Class ;
rdfs:label "disease or phenotypic feature exposure" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:TimeType ;
owl:onProperty biolink:timepoint ],
biolink:Attribute,
biolink:ExposureEvent,
biolink:PathologicalEntityMixin ;
skos:definition "A disease or phenotypic feature state, when viewed as an exposure, represents an precondition, leading to or influencing an outcome, e.g. HIV predisposing an individual to infections; a relative deficiency of skin pigmentation predisposing an individual to skin cancer." .
biolink:DiseaseOrPhenotypicFeatureOutcome a owl:Class ;
rdfs:label "disease or phenotypic feature outcome" ;
rdfs:subClassOf biolink:Outcome ;
skos:definition "Physiological outcomes resulting from an exposure event which is the manifestation of a disease or other characteristic phenotype." .
biolink:DiseaseOrPhenotypicFeatureToGeneticInheritanceAssociation a owl:Class ;
rdfs:label "disease or phenotypic feature to genetic inheritance association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:GeneticInheritance ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
biolink:Association,
biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
skos:definition "An association between either a disease or a phenotypic feature and its mode of (genetic) inheritance." .
biolink:DiseaseOrPhenotypicFeatureToLocationAssociation a owl:Class ;
rdfs:label "disease or phenotypic feature to location association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:AnatomicalEntity ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
biolink:Association,
biolink:DiseaseOrPhenotypicFeatureToEntityAssociationMixin ;
skos:definition "An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site." .
biolink:DiseaseToExposureEventAssociation a owl:Class ;
rdfs:label "disease to exposure event association" ;
rdfs:subClassOf biolink:Association,
biolink:DiseaseToEntityAssociationMixin,
biolink:EntityToExposureEventAssociationMixin ;
skos:definition "An association between an exposure event and a disease." .
biolink:DiseaseToPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "disease to phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_percentage ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_count ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_quotient ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:PhenotypicFeature ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:BiologicalSex ;
owl:onProperty biolink:sex_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:Disease ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_total ],
biolink:Association,
biolink:DiseaseToEntityAssociationMixin,
biolink:EntityToPhenotypicFeatureAssociationMixin ;
skos:closeMatch dcid:DiseaseSymptomAssociation ;
skos:definition "An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way." .
biolink:DrugLabel a owl:Class ;
rdfs:label "drug label" ;
rdfs:subClassOf biolink:Publication ;
skos:broadMatch NCIT-OBO:C41203 ;
skos:definition "a document accompanying a drug or its container that provides written, printed or graphic information about the drug, including drug contents, specific instructions or warnings for administration, storage and disposal instructions, etc. " .
biolink:DrugToGeneAssociation a owl:Class ;
rdfs:label "drug to gene association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
biolink:Association,
biolink:DrugToEntityAssociationMixin ;
skos:definition "An interaction between a drug and a gene or gene product." ;
skos:relatedMatch SIO:001257 .
biolink:DrugToGeneInteractionExposure a owl:Class ;
rdfs:label "drug to gene interaction exposure" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:allValuesFrom biolink:Gene ;
owl:onProperty biolink:has_gene_or_gene_product ],
biolink:DrugExposure,
biolink:GeneGroupingMixin ;
skos:definition "drug to gene interaction exposure is a drug exposure is where the interactions of the drug with specific genes are known to constitute an 'exposure' to the organism, leading to or influencing an outcome." .
biolink:DruggableGeneToDiseaseAssociation a owl:Class ;
rdfs:label "druggable gene to disease association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:allValuesFrom biolink:DruggableGeneCategoryEnum ;
owl:onProperty biolink:has_evidence ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
biolink:EntityToDiseaseAssociationMixin,
biolink:GeneToDiseaseAssociation,
biolink:GeneToEntityAssociationMixin .
biolink:EntityToDiseaseAssociation a owl:Class ;
rdfs:label "entity to disease association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FDAApprovalStatusEnum ;
owl:onProperty biolink:FDA_approval_status ],
biolink:Association .
biolink:EntityToPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "entity to phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FDAApprovalStatusEnum ;
owl:onProperty biolink:FDA_approval_status ],
biolink:Association .
biolink:EnvironmentalFeature a owl:Class ;
rdfs:label "environmental feature" ;
rdfs:subClassOf biolink:PlanetaryEntity ;
skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_01000254> .
biolink:EnvironmentalFoodContaminant a owl:Class ;
rdfs:label "environmental food contaminant" ;
rdfs:subClassOf biolink:ChemicalEntity ;
skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_78299> .
biolink:EnvironmentalProcess a owl:Class ;
rdfs:label "environmental process" ;
rdfs:subClassOf biolink:Occurrent,
biolink:PlanetaryEntity ;
skos:exactMatch <http://purl.obolibrary.org/obo/ENVO_02500000> .
biolink:EpidemiologicalOutcome a owl:Class ;
rdfs:label "epidemiological outcome" ;
rdfs:subClassOf biolink:Outcome ;
skos:definition "An epidemiological outcome, such as societal disease burden, resulting from an exposure event." ;
skos:relatedMatch <http://purl.obolibrary.org/obo/NCIT_C19291> .
biolink:Event a owl:Class ;
rdfs:label "event" ;
rdfs:subClassOf biolink:NamedThing ;
skos:definition "Something that happens at a given place and time." ;
skos:exactMatch STY:T051,
<http://purl.obolibrary.org/obo/NCIT_C25499> .
biolink:ExonToTranscriptRelationship a owl:Class ;
rdfs:label "exon to transcript relationship" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onClass biolink:Transcript ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:Exon ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
biolink:SequenceFeatureRelationship ;
skos:definition "A transcript is formed from multiple exons" .
biolink:ExposureEventToOutcomeAssociation a owl:Class ;
rdfs:label "exposure event to outcome association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:TimeType ;
owl:onProperty biolink:temporal_context_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:PopulationOfIndividualOrganisms ;
owl:onProperty biolink:population_context_qualifier ],
biolink:Association,
biolink:EntityToOutcomeAssociationMixin ;
skos:definition "An association between an exposure event and an outcome." .
biolink:ExposureEventToPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "exposure event to phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_count ],
[ a owl:Restriction ;
owl:onClass biolink:ExposureEvent ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:BiologicalSex ;
owl:onProperty biolink:sex_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Integer ;
owl:onProperty biolink:has_total ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_percentage ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_quotient ],
biolink:Association,
biolink:EntityToPhenotypicFeatureAssociationMixin ;
skos:definition "Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype." .
biolink:Food a owl:Class ;
rdfs:label "food" ;
rdfs:subClassOf biolink:ChemicalMixture ;
skos:definition "A substance consumed by a living organism as a source of nutrition" ;
skos:exactMatch STY:T168 .
biolink:FoodAdditive a owl:Class ;
rdfs:label "food additive" ;
rdfs:subClassOf biolink:ChemicalEntity ;
skos:relatedMatch <http://purl.obolibrary.org/obo/CHEBI_64047> .
biolink:Fungus a owl:Class ;
rdfs:label "fungus" ;
rdfs:subClassOf biolink:CellularOrganism ;
skos:definition "A kingdom of eukaryotic, heterotrophic organisms that live as saprobes or parasites, including mushrooms, yeasts, smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi refer to those that grow as multicellular colonies (mushrooms and molds)." ;
skos:exactMatch STY:T004,
<http://purl.obolibrary.org/obo/FOODON_03411261>,
<http://purl.obolibrary.org/obo/NCIT_C14209> ;
skos:narrowMatch <http://purl.obolibrary.org/obo/FOODON_03315605>,
<http://purl.obolibrary.org/obo/NCBITaxon_1670606> .
biolink:GeneAsAModelOfDiseaseAssociation a owl:Class ;
rdfs:label "gene as a model of disease association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:FrequencyValue ;
owl:onProperty biolink:frequency_qualifier ],
biolink:EntityToDiseaseAssociationMixin,
biolink:GeneToDiseaseAssociation,
biolink:ModelToDiseaseAssociationMixin .
biolink:GeneHasVariantThatContributesToDiseaseAssociation a owl:Class ;
rdfs:label "gene has variant that contributes to disease association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:String ;
owl:onProperty biolink:subject_form_or_variant_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:Disease ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:onClass biolink:GeneOrGeneProduct ;
owl:onProperty rdf:subject ;
owl:qualifiedCardinality 1 ],
biolink:GeneToDiseaseAssociation .
biolink:GeneToDiseaseOrPhenotypicFeatureAssociation a owl:Class ;
rdfs:label "gene to disease or phenotypic feature association" ;
rdfs:subClassOf [ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:GeneOrGeneProductOrChemicalEntityAspectEnum ;
owl:onProperty biolink:subject_aspect_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:PredicateType ;
owl:onProperty rdf:predicate ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:Onset ;
owl:onProperty biolink:onset_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:BiologicalSex ;
owl:onProperty biolink:sex_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass linkml:Double ;
owl:onProperty biolink:has_percentage ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:DirectionQualifierEnum ;
owl:onProperty biolink:object_direction_qualifier ],
[ a owl:Restriction ;
owl:onClass biolink:DiseaseOrPhenotypicFeature ;
owl:onProperty rdf:object ;
owl:qualifiedCardinality 1 ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;
owl:onClass biolink:SeverityValue ;
owl:onProperty biolink:severity_qualifier ],
[ a owl:Restriction ;
owl:maxQualifiedCardinality 1 ;