notebooks/bte_clustering.ipynb

{
 "cells": [
  {
   "cell_type": "raw",
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/"
    },
    "id": "UZZqPBS0UppM",
    "outputId": "281abfa6-b935-4d99-a267-e237900aa5dc"
   },
   "source": [
    "!pip install numpy pandas requests requests_cache SetSimilaritySearch"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {
    "id": "uG7JfetZjcXH"
   },
   "outputs": [],
   "source": [
    "from copy import copy,deepcopy\n",
    "from itertools import combinations\n",
    "import json\n",
    "import textwrap\n",
    "\n",
    "\n",
    "from fisher import pvalue_npy\n",
    "import matplotlib.pyplot as plt\n",
    "import networkx as nx\n",
    "import pandas as pd"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {
    "id": "rzoUUSDeVz0a"
   },
   "outputs": [],
   "source": [
    "import requests\n",
    "import requests_cache\n",
    "\n",
    "\n",
    "requests_cache.install_cache(\n",
    "    \"pfocr_cache\",\n",
    "    allowable_methods=['GET', 'POST'],\n",
    "    stale_if_error=False,\n",
    ")\n",
    "#requests_cache.remove_expired_responses()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "id": "j9DiSC9NU_Fa"
   },
   "source": [
    "# BTE: Cluster TRAPI Results by Selected PFOCR Figures\n",
    "\n",
    "From discussion with Andrew, we want to first identify a set of figures that can serve to cluster the TRAPI results. We can call these the \"cluster figures\".\n",
    "\n",
    "**Identify Cluster Figures**\n",
    "\n",
    "We identify the top cluster figures by iteratively running Fisher's Exact Test to identify PFOCR figures that are most similar to all the CURIEs from the BTE TRAPI results. To get each cluster figure, we do the following:\n",
    "\n",
    "1. Run Fisher's Exact Test for the CURIEs from each figure vs. the set of the unique CURIEs found from all the TRAPI results, limiting each  set of CURIEs to those with categories found in both PFOCR and BTE TRAPI, e.g., \"disease\" is found in PFOCR and \"biolink:Disease\" is found in BTE TRAPI\n",
    "2. Select the figure with the lowest p-value as a cluster figure\n",
    "3. Exclude that figure and the CURIEs in it\n",
    "4. Repeat to get the next cluster figure, continuing until:\n",
    "    - no more figures match the remaining BTE TRAPI results\n",
    "    - we've found some set number of figures (20)\n",
    "    - we run out of BTE TRAPI results\n",
    "    - we run out of PFOCR figures\n",
    "\n",
    "**Cluster BTE TRAPI Results by Selected PFOCR Figures (Cluster Figures)**\n",
    "\n",
    "Once we have a set of cluster figures, we use them to cluster the BTE TRAPI results. We do this by running Fisher's Exact Test to identify which Cluster Figure each BTE TRAPI result is most similar to. We don't actually cluster the TRAPI results by figure, however, because if a result is highly relevant to two figures, it can show up in both. It's more accurate to think of the figure as being a different view of the TRAPI results.\n",
    "\n",
    "**View TRAPI Results by PFOCR Figure**\n",
    "\n",
    "With BTE TRAPI results \"clustered\" (not actually clustered, because we show the same result multiple times for different figures if it's closely related to both) by PFOCR figure, we display the top figures, each with their most closely related BTE TRAPI results."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "id": "TxW41muraAFL"
   },
   "source": [
    "## Get BTE TRAPI Results\n",
    "\n",
    "RAB13"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/"
    },
    "id": "N71NYHWeVCj9",
    "outputId": "d8c2c9ae-9750-455c-ff61-b357b4ff0b2d",
    "tags": []
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "200\n",
      "got response from cache\n"
     ]
    }
   ],
   "source": [
    "query = {\n",
    "    \"message\": {\n",
    "        \"query_graph\": {\n",
    "            \"edges\": {\n",
    "                \"e0\": {\n",
    "                    \"subject\": \"n0\",\n",
    "                    \"object\": \"n1\",\n",
    "                    \"predicates\": [\n",
    "                        \"biolink:entity_regulates_entity\",\n",
    "                        \"biolink:genetically_interacts_with\"\n",
    "                    ]\n",
    "                },\n",
    "                \"e1\": {\n",
    "                    \"subject\": \"n1\",\n",
    "                    \"object\": \"n2\",\n",
    "                    \"predicates\": [\n",
    "                        \"biolink:related_to\"\n",
    "                    ]\n",
    "                }\n",
    "            },\n",
    "            \"nodes\": {\n",
    "                \"n0\": {\n",
    "                    \"ids\": [\n",
    "                        \"NCBIGene:5872\"\n",
    "                    ],\n",
    "                    \"categories\": [\n",
    "                        \"biolink:Gene\"\n",
    "                    ]\n",
    "                },\n",
    "                \"n1\": {\n",
    "                    \"categories\": [\n",
    "                        \"biolink:Gene\"\n",
    "                    ],\n",
    "                },\n",
    "                \"n2\": {\n",
    "                    \"categories\": [\n",
    "                        \"biolink:SmallMolecule\"\n",
    "                    ]\n",
    "                }\n",
    "            }\n",
    "        }\n",
    "    }\n",
    "}\n",
    "\n",
    "trapi_response = requests.post(\"http://localhost:3000/v1/query\", json=query)\n",
    "#trapi_response = requests.post(\"https://api.bte.ncats.io/v1/query\", json=query)\n",
    "#trapi_response = requests.post(\"https://arax.ncats.io/api/rtxkg2/v1.2/query\", json=query)\n",
    "#trapi_response = requests.post(\"https://arax.ncats.io/api/arax/v1.2/query\", json=query)\n",
    "print(trapi_response.status_code)\n",
    "if trapi_response.status_code != 200:\n",
    "    raise Exception(trapi_response.text)\n",
    "if trapi_response.from_cache:\n",
    "    print(f\"got response from cache\")\n",
    "\n",
    "trapi_message = trapi_response.json()[\"message\"]\n",
    "\n",
    "if len(trapi_message[\"results\"]) == 0:\n",
    "    raise Exception(f'No results returned')"
   ]
  },
  {
   "cell_type": "raw",
   "metadata": {},
   "source": [
    "print(json.dumps(query))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Analyze this GraphML file in Cytoscape: ./bte_sleeve_query_template.graphml\n"
     ]
    },
    {
     "data": {
      "text/plain": [
       "{('n0',\n",
       "  'n1'): Text(0.4999999999999998, 0.010922077232850467, 'biolink:entity_regulates_entity\\nbiolink:genetically_interacts_with'),\n",
       " ('n1',\n",
       "  'n2'): Text(-0.4994281440889846, -0.010909459543215703, 'biolink:related_to')}"
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    },
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "from collections import defaultdict\n",
    "\n",
    "\n",
    "G = nx.Graph()\n",
    "query_node_labels = {}\n",
    "for k, v in query['message']['query_graph']['nodes'].items():\n",
    "    node_ids = v.get('ids', [])\n",
    "    node_categories = v.get('categories', [])\n",
    "    G.add_node(k, categories=', '.join(node_categories))\n",
    "    query_node_labels[k] = '\\n'.join([k] + node_ids + node_categories)\n",
    "    #G.add_node(k, color='red')\n",
    "\n",
    "query_edge_labels = {}\n",
    "q_node_id_keys = set(['object', 'subject'])\n",
    "for q_edge_id,edge_v in query['message']['query_graph']['edges'].items():\n",
    "    for predicate in edge_v['predicates']:\n",
    "        G.add_edge(edge_v['subject'], edge_v['object'], predicate=predicate)\n",
    "    #G.add_edge(edge_v['subject'], edge_v['object'], predicates=', '.join(edge_v['predicates']))\n",
    "    #G.add_edge(edge_v['subject'], edge_v['object'], predicates=[1,2,3])\n",
    "    #G.add_edge(edge_v['subject'], edge_v['object'])\n",
    "    query_edge_labels[(edge_v['subject'], edge_v['object'])] = '\\n'.join(edge_v['predicates'])\n",
    "    \n",
    "query_template_f = './bte_sleeve_query_template.graphml'\n",
    "print(f'Analyze this GraphML file in Cytoscape: {query_template_f}')\n",
    "nx.write_graphml(G, query_template_f)\n",
    "\n",
    "options = {\n",
    "    'node_color': 'yellow',\n",
    "    'node_size': 5000,\n",
    "    'edge_color': 'black',\n",
    "    'width': 3,\n",
    "}\n",
    "query_template_layout = nx.spring_layout(G)\n",
    "nx.draw(G, pos=query_template_layout, **options)\n",
    "nx.draw_networkx_labels(G, query_template_layout, labels=query_node_labels, font_size=12,\n",
    "                        font_color='k', font_family='sans-serif',\n",
    "                        font_weight='normal', alpha=None, bbox=None, horizontalalignment='center',\n",
    "                        verticalalignment='center', ax=None, clip_on=False)\n",
    "nx.draw_networkx_edge_labels(G, pos=query_template_layout,\n",
    "                             edge_labels=query_edge_labels,\n",
    "                             label_pos=0.5, \n",
    "                             font_size=10, font_color='k', font_family='sans-serif',\n",
    "                             font_weight='normal', alpha=None, bbox=None, horizontalalignment='center',\n",
    "                             verticalalignment='center', ax=None, rotate=True, clip_on=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "# NOTE: we're including categories specified in the query template\n",
    "# in the next cell, and in a cell further down, we're also including\n",
    "# any categories from the TRAPI results.\n",
    "#\n",
    "# TODO: Some categories are supersets of others. Should we handle\n",
    "# this systematically?\n",
    "\n",
    "curie_categories = set()\n",
    "for v in query[\"message\"][\"query_graph\"][\"nodes\"].values():\n",
    "    if \"categories\" in v:\n",
    "        for category in v[\"categories\"]:\n",
    "            curie_categories.add(category)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/"
    },
    "id": "XRfyhW_Is73C",
    "outputId": "76ae9c51-0587-4f1e-91ac-f8d728ce6878"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "curie UMLS:C0903898 has multiple primary names: NATEGLINIDE and nateglinide\n",
      "curie UMLS:C0021641 has multiple primary names: Iletin and Insulin\n",
      "all CURIE prefixes found:\n",
      "{'PUBCHEM.COMPOUND', 'UNII', 'CHEBI', 'GTOPDB', 'UMLS', 'PR', 'NCBIGene', 'UniProtKB', 'HMDB', 'OMIM', 'CHEMBL.COMPOUND', 'ENSEMBL', 'MESH', 'HGNC', 'KEGG.COMPOUND', 'DrugCentral', 'INCHIKEY', 'DRUGBANK', 'CAS'}\n",
      "\n",
      "unified CURIE prefixes found:\n",
      "{'NCBIGene', 'MESH'}\n",
      "\n",
      "failed to unify 886 CURIEs\n"
     ]
    }
   ],
   "source": [
    "# for genes/gene products, chemicals and diseases\n",
    "preferred_prefixes = set([\"NCBIGene\", \"MESH\"])\n",
    "trapi_results_unified_curies = set()\n",
    "unification_failed_curies = set()\n",
    "unified_prefixes = set()\n",
    "all_prefixes = set()\n",
    "curie_to_name = dict()\n",
    "curie_to_categories = dict()\n",
    "curie_to_unified_curie = dict()\n",
    "for k, v in trapi_message[\"knowledge_graph\"][\"nodes\"].items():\n",
    "    name = v[\"name\"]\n",
    "    categories = v[\"categories\"]\n",
    "    curie_categories |= set(categories)\n",
    "\n",
    "    for a in v[\"attributes\"]:\n",
    "        if a[\"attribute_type_id\"] == \"biolink:xref\":\n",
    "            curies = a[\"value\"]\n",
    "\n",
    "            # k should always be one of the curies\n",
    "            if not k in curies:\n",
    "                raise Exception(f\"key {k} not in {curies}\")\n",
    "\n",
    "            unified_curie = None\n",
    "            intersecting_trapi_results_unified_curies = trapi_results_unified_curies.intersection(set(curies))\n",
    "            if len(intersecting_trapi_results_unified_curies) > 1:\n",
    "                raise Exception(f\"matching multiple: {k} to {list(intersecting_trapi_results_unified_curies)}\")\n",
    "            elif len(intersecting_trapi_results_unified_curies) == 1:\n",
    "                unified_curie = list(intersecting_trapi_results_unified_curies)[0]\n",
    "            else:\n",
    "                # get curie for preferred prefix. usually this is k, but not always.\n",
    "                for curie in curies:\n",
    "                    [prefix, identifier] = curie.split(\":\")\n",
    "                    if prefix in preferred_prefixes:\n",
    "                        unified_curie = curie\n",
    "                        trapi_results_unified_curies.add(unified_curie)\n",
    "                        break\n",
    "\n",
    "            if not unified_curie:\n",
    "                if k in curie_to_unified_curie:\n",
    "                    unified_curie = curie_to_unified_curie[k]\n",
    "                else:\n",
    "                    unification_failed_curies.add(k)\n",
    "                    break\n",
    "\n",
    "                #raise Exception(f\"failed to find a unified curie for {k} in {curies}\")\n",
    "\n",
    "            [unified_prefix, unified_identifier] = unified_curie.split(\":\")\n",
    "            unified_prefixes.add(unified_prefix)\n",
    "\n",
    "            for curie in curies:\n",
    "                [prefix, identifier] = curie.split(\":\")\n",
    "                all_prefixes.add(prefix)\n",
    "                if not curie in curie_to_unified_curie:\n",
    "                    curie_to_unified_curie[curie] = unified_curie\n",
    "                if not curie in curie_to_name:\n",
    "                    curie_to_name[curie] = name\n",
    "                    curie_to_categories[curie] = categories\n",
    "                elif curie_to_name[curie] != name:\n",
    "                    print(f\"curie {curie} has multiple primary names: {curie_to_name[curie]} and {name}\")\n",
    "                    #raise Exception(f\"curie{curie} has multiple names: {curie_to_name[curie]} and {name}\")\n",
    "\n",
    "\n",
    "#print(f'curie_categories: {curie_categories}')\n",
    "#print(\"\")\n",
    "#print(f\"curie_to_name key count: {len(curie_to_name.keys())}\")\n",
    "#print(f\"curie_to_unified_curie key count: {len(curie_to_unified_curie.keys())}\")\n",
    "#print(\"\")\n",
    "print(\"all CURIE prefixes found:\")\n",
    "print(all_prefixes)\n",
    "print(\"\")\n",
    "print(\"unified CURIE prefixes found:\")\n",
    "print(unified_prefixes)\n",
    "print(\"\")\n",
    "print(f\"failed to unify {len(unification_failed_curies)} CURIEs\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [],
   "source": [
    "columns = []\n",
    "q_node_id_keys = set([\"object\", \"subject\"])\n",
    "q_node_ids = []\n",
    "q_edge_ids = []\n",
    "for q_edge_id,edge_v in query[\"message\"][\"query_graph\"][\"edges\"].items():\n",
    "    q_edge_ids.append(q_edge_id)\n",
    "    q_node_id_found = False\n",
    "    for k,v in edge_v.items():\n",
    "        if (k in q_node_id_keys) and (type(v) is str):\n",
    "            if v not in columns:\n",
    "                q_node_ids.append(v)\n",
    "                columns.append(v)\n",
    "            if not q_node_id_found:\n",
    "                q_node_id_found = True\n",
    "                columns.append(q_edge_id)\n",
    "\n",
    "query_nodes_with_ids = set()\n",
    "for k, v in query['message']['query_graph']['nodes'].items():\n",
    "    node_ids = v.get('ids', [])\n",
    "    if node_ids:\n",
    "        query_nodes_with_ids.add(k)\n",
    "\n",
    "for q_node_id in q_node_ids:\n",
    "    columns.append(f\"{q_node_id}_original_curie\")\n",
    "    columns.append(f\"{q_node_id}_unified_curie\")\n",
    "\n",
    "columns.append(\"unified_curie_set\")\n",
    "\n",
    "trapi_result_columns = []\n",
    "for i in range(len(q_node_ids)):\n",
    "    trapi_result_columns.append(q_node_ids[i])\n",
    "    if i < len(q_edge_ids):\n",
    "        trapi_result_columns.append(q_edge_ids[i])\n",
    "\n",
    "unified_curie_columns = []\n",
    "for q_node_id in q_node_ids:\n",
    "    unified_curie_columns.append(f\"{q_node_id}_unified_curie\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {
    "id": "Wjqcf5E4Yk_h"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "warning: predicate direction(s) may be switched\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>n0</th>\n",
       "      <th>e0</th>\n",
       "      <th>n1</th>\n",
       "      <th>e1</th>\n",
       "      <th>n2</th>\n",
       "      <th>n0_original_curie</th>\n",
       "      <th>n0_unified_curie</th>\n",
       "      <th>n1_original_curie</th>\n",
       "      <th>n1_unified_curie</th>\n",
       "      <th>n2_original_curie</th>\n",
       "      <th>n2_unified_curie</th>\n",
       "      <th>unified_curie_set</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>RAB18</td>\n",
       "      <td>entity_negatively_regulated_by_entity</td>\n",
       "      <td>WATER</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>CHEMBL.COMPOUND:CHEMBL1098659</td>\n",
       "      <td>MESH:D014867</td>\n",
       "      <td>{MESH:D014867, NCBIGene:22931, NCBIGene:5872}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>RAB18</td>\n",
       "      <td>entity_positively_regulated_by_entity</td>\n",
       "      <td>WATER</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>CHEMBL.COMPOUND:CHEMBL1098659</td>\n",
       "      <td>MESH:D014867</td>\n",
       "      <td>{MESH:D014867, NCBIGene:22931, NCBIGene:5872}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>RAB18</td>\n",
       "      <td>entity_positively_regulated_by_entity</td>\n",
       "      <td>Isopropyl-beta-D-thiogalactopyranoside</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>PUBCHEM.COMPOUND:656894</td>\n",
       "      <td>MESH:D007544</td>\n",
       "      <td>{NCBIGene:5872, NCBIGene:22931, MESH:D007544}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>RAB18</td>\n",
       "      <td>entity_positively_regulated_by_entity</td>\n",
       "      <td>Trichostatin A</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>PUBCHEM.COMPOUND:444732</td>\n",
       "      <td>MESH:C012589</td>\n",
       "      <td>{MESH:C012589, NCBIGene:22931, NCBIGene:5872}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>RAB18</td>\n",
       "      <td>entity_negatively_regulated_by_entity</td>\n",
       "      <td>Mannitol</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>PUBCHEM.COMPOUND:6251</td>\n",
       "      <td>MESH:D008353</td>\n",
       "      <td>{NCBIGene:22931, MESH:D008353, NCBIGene:5872}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6125</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>coexists_with</td>\n",
       "      <td>5' Flanking Region</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>UMLS:C0949645</td>\n",
       "      <td>MESH:D024506</td>\n",
       "      <td>{MESH:D024506, NCBIGene:5872, NCBIGene:7046}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6126</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>coexists_with</td>\n",
       "      <td>1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-beta-D-...</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>PUBCHEM.COMPOUND:133445</td>\n",
       "      <td>MESH:C070423</td>\n",
       "      <td>{MESH:C070423, NCBIGene:5872, NCBIGene:7046}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6127</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>affects_response_to</td>\n",
       "      <td>Thioacetamide</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>PUBCHEM.COMPOUND:2723949</td>\n",
       "      <td>MESH:D013853</td>\n",
       "      <td>{MESH:D013853, NCBIGene:5872, NCBIGene:7046}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6128</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>increases_response_to</td>\n",
       "      <td>Thioacetamide</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>PUBCHEM.COMPOUND:2723949</td>\n",
       "      <td>MESH:D013853</td>\n",
       "      <td>{MESH:D013853, NCBIGene:5872, NCBIGene:7046}</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6129</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>coexists_with</td>\n",
       "      <td>Progesterone</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>PUBCHEM.COMPOUND:5994</td>\n",
       "      <td>MESH:D011374</td>\n",
       "      <td>{MESH:D011374, NCBIGene:5872, NCBIGene:7046}</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>6130 rows × 12 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "         n0                                  e0      n1  \\\n",
       "0     RAB13  entity_positively_regulates_entity   RAB18   \n",
       "1     RAB13  entity_positively_regulates_entity   RAB18   \n",
       "2     RAB13  entity_positively_regulates_entity   RAB18   \n",
       "3     RAB13  entity_positively_regulates_entity   RAB18   \n",
       "4     RAB13  entity_positively_regulates_entity   RAB18   \n",
       "...     ...                                 ...     ...   \n",
       "6125  RAB13          genetically_interacts_with  TGFBR1   \n",
       "6126  RAB13          genetically_interacts_with  TGFBR1   \n",
       "6127  RAB13          genetically_interacts_with  TGFBR1   \n",
       "6128  RAB13          genetically_interacts_with  TGFBR1   \n",
       "6129  RAB13          genetically_interacts_with  TGFBR1   \n",
       "\n",
       "                                         e1  \\\n",
       "0     entity_negatively_regulated_by_entity   \n",
       "1     entity_positively_regulated_by_entity   \n",
       "2     entity_positively_regulated_by_entity   \n",
       "3     entity_positively_regulated_by_entity   \n",
       "4     entity_negatively_regulated_by_entity   \n",
       "...                                     ...   \n",
       "6125                          coexists_with   \n",
       "6126                          coexists_with   \n",
       "6127                    affects_response_to   \n",
       "6128                  increases_response_to   \n",
       "6129                          coexists_with   \n",
       "\n",
       "                                                     n2 n0_original_curie  \\\n",
       "0                                                 WATER     NCBIGene:5872   \n",
       "1                                                 WATER     NCBIGene:5872   \n",
       "2                Isopropyl-beta-D-thiogalactopyranoside     NCBIGene:5872   \n",
       "3                                        Trichostatin A     NCBIGene:5872   \n",
       "4                                              Mannitol     NCBIGene:5872   \n",
       "...                                                 ...               ...   \n",
       "6125                                 5' Flanking Region     NCBIGene:5872   \n",
       "6126  1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-beta-D-...     NCBIGene:5872   \n",
       "6127                                      Thioacetamide     NCBIGene:5872   \n",
       "6128                                      Thioacetamide     NCBIGene:5872   \n",
       "6129                                       Progesterone     NCBIGene:5872   \n",
       "\n",
       "     n0_unified_curie n1_original_curie n1_unified_curie  \\\n",
       "0       NCBIGene:5872    NCBIGene:22931   NCBIGene:22931   \n",
       "1       NCBIGene:5872    NCBIGene:22931   NCBIGene:22931   \n",
       "2       NCBIGene:5872    NCBIGene:22931   NCBIGene:22931   \n",
       "3       NCBIGene:5872    NCBIGene:22931   NCBIGene:22931   \n",
       "4       NCBIGene:5872    NCBIGene:22931   NCBIGene:22931   \n",
       "...               ...               ...              ...   \n",
       "6125    NCBIGene:5872     NCBIGene:7046    NCBIGene:7046   \n",
       "6126    NCBIGene:5872     NCBIGene:7046    NCBIGene:7046   \n",
       "6127    NCBIGene:5872     NCBIGene:7046    NCBIGene:7046   \n",
       "6128    NCBIGene:5872     NCBIGene:7046    NCBIGene:7046   \n",
       "6129    NCBIGene:5872     NCBIGene:7046    NCBIGene:7046   \n",
       "\n",
       "                  n2_original_curie n2_unified_curie  \\\n",
       "0     CHEMBL.COMPOUND:CHEMBL1098659     MESH:D014867   \n",
       "1     CHEMBL.COMPOUND:CHEMBL1098659     MESH:D014867   \n",
       "2           PUBCHEM.COMPOUND:656894     MESH:D007544   \n",
       "3           PUBCHEM.COMPOUND:444732     MESH:C012589   \n",
       "4             PUBCHEM.COMPOUND:6251     MESH:D008353   \n",
       "...                             ...              ...   \n",
       "6125                  UMLS:C0949645     MESH:D024506   \n",
       "6126        PUBCHEM.COMPOUND:133445     MESH:C070423   \n",
       "6127       PUBCHEM.COMPOUND:2723949     MESH:D013853   \n",
       "6128       PUBCHEM.COMPOUND:2723949     MESH:D013853   \n",
       "6129          PUBCHEM.COMPOUND:5994     MESH:D011374   \n",
       "\n",
       "                                  unified_curie_set  \n",
       "0     {MESH:D014867, NCBIGene:22931, NCBIGene:5872}  \n",
       "1     {MESH:D014867, NCBIGene:22931, NCBIGene:5872}  \n",
       "2     {NCBIGene:5872, NCBIGene:22931, MESH:D007544}  \n",
       "3     {MESH:C012589, NCBIGene:22931, NCBIGene:5872}  \n",
       "4     {NCBIGene:22931, MESH:D008353, NCBIGene:5872}  \n",
       "...                                             ...  \n",
       "6125   {MESH:D024506, NCBIGene:5872, NCBIGene:7046}  \n",
       "6126   {MESH:C070423, NCBIGene:5872, NCBIGene:7046}  \n",
       "6127   {MESH:D013853, NCBIGene:5872, NCBIGene:7046}  \n",
       "6128   {MESH:D013853, NCBIGene:5872, NCBIGene:7046}  \n",
       "6129   {MESH:D011374, NCBIGene:5872, NCBIGene:7046}  \n",
       "\n",
       "[6130 rows x 12 columns]"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "trapi_results = trapi_message[\"results\"]\n",
    "\n",
    "result_row_data = []\n",
    "for trapi_result in trapi_results:\n",
    "    curie_to_qnode_ids = dict()\n",
    "    for qnode_id, entries in trapi_result[\"node_bindings\"].items():\n",
    "        for entry in entries:\n",
    "            curie = entry[\"id\"]\n",
    "            if curie not in curie_to_qnode_ids:\n",
    "                curie_to_qnode_ids[curie] = []\n",
    "            curie_to_qnode_ids[curie].append(qnode_id)\n",
    "\n",
    "    row_data_template = dict()\n",
    "    q_edge_id_to_predicates = dict()\n",
    "    trapi_result_curie_set = set()\n",
    "    for qedge_id, entries in trapi_result[\"edge_bindings\"].items():\n",
    "        for entry in entries:\n",
    "            curie = entry[\"id\"]\n",
    "            kg_entry = trapi_message[\"knowledge_graph\"][\"edges\"][curie]\n",
    "            subject_curie = kg_entry[\"subject\"]\n",
    "            object_curie = kg_entry[\"object\"]\n",
    "            predicate_curie = kg_entry[\"predicate\"]\n",
    "            [predicate_prefix, predicate_identifier] = predicate_curie.split(\":\")\n",
    "\n",
    "            if qedge_id not in q_edge_id_to_predicates:\n",
    "                q_edge_id_to_predicates[qedge_id] = set()\n",
    "            q_edge_id_to_predicates[qedge_id].add(predicate_identifier)\n",
    "\n",
    "            for curie in [subject_curie, object_curie]:\n",
    "                for qnode_id in curie_to_qnode_ids[curie]:\n",
    "                    if curie in curie_to_unified_curie:\n",
    "                        unified_curie = curie_to_unified_curie[curie]\n",
    "                    else:\n",
    "                        break\n",
    "\n",
    "                    name = curie_to_name[curie]\n",
    "                    row_data_template[qnode_id] = name\n",
    "\n",
    "                    trapi_result_curie_set.add(unified_curie)\n",
    "                    row_data_template[qnode_id + \"_original_curie\"] = curie\n",
    "                    row_data_template[qnode_id + \"_unified_curie\"] = unified_curie\n",
    "\n",
    "    if len(trapi_result_curie_set) != len(q_node_ids):\n",
    "        #print(f'skipping {list(curie_to_qnode_ids.keys())}')\n",
    "        continue\n",
    "\n",
    "    row_data_template[\"unified_curie_set\"] = trapi_result_curie_set\n",
    "    q_edge_ids_processed = set()\n",
    "    row_datas = [row_data_template]\n",
    "    for q_edge_id,predicates in q_edge_id_to_predicates.items():\n",
    "        next_row_datas = []\n",
    "        for row_data in row_datas:\n",
    "            for predicate in predicates:\n",
    "                next_row_data = deepcopy(row_data)\n",
    "                next_row_data[q_edge_id] = predicate\n",
    "                next_row_datas.append(\n",
    "                    next_row_data \n",
    "                )\n",
    "        row_datas = next_row_datas\n",
    "    result_row_data += row_datas\n",
    "\n",
    "print(\"warning: predicate direction(s) may be switched\")\n",
    "trapi_results_df = pd.DataFrame.from_records(result_row_data, columns=columns)\n",
    "trapi_results_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'NCBIGene:5872'}"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "user_specified_ids = set()\n",
    "for query_node in query_nodes_with_ids:\n",
    "    user_specified_ids.update(trapi_results_df[f'{query_node}_unified_curie'].tolist())\n",
    "user_specified_ids"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Unique CURIE count per query node:"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "n0: 1\n",
      "n1: 12\n",
      "n2: 1347\n"
     ]
    }
   ],
   "source": [
    "for q_node_id in q_node_ids:\n",
    "    print(f'{q_node_id}: {len(set(trapi_results_df[q_node_id]))}')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Total results count (excluding any that couldn't be unified):"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "3158"
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(set(trapi_results_df[\"unified_curie_set\"].map(sorted).map(tuple)))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "That's too too high for a researcher to efficiently go through manually. Let's try filtering to make that more manageable."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "id": "uCW1x4PxnjYJ",
    "tags": []
   },
   "source": [
    "## Get PFOCR Data\n",
    "\n",
    "We could get it from the API, but for now, we'll just go ahead and download the entire JSON file we gave to BTE."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/"
    },
    "id": "OyJJUHbepKp2",
    "outputId": "7237b5f0-8740-47cb-9e3d-b03ea02bdcab"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "status_code: 200\n"
     ]
    }
   ],
   "source": [
    "pfocr_url = \"https://www.dropbox.com/s/1f14t5zaseocyg6/bte_chemicals_diseases_genes.ndjson?dl=1\"\n",
    "pfocr_request = requests.get(pfocr_url)\n",
    "print(f\"status_code: {pfocr_request.status_code}\")\n",
    "if pfocr_request.status_code != 200:\n",
    "    print(pfocr_request.text)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {
    "id": "8fUaenkS0gg1"
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>figure_id</th>\n",
       "      <th>chemical_curie_set</th>\n",
       "      <th>disease_curie_set</th>\n",
       "      <th>gene_curie_set</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>PMC5732092__cshperspect-CYT-028522_F2.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:3326, NCBIGene:5196, NCBIGene:4790, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>PMC5793760__cshperspect-TGF-022210_F4.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:649, NCBIGene:7046, NCBIGene:653, NC...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>PMC5793761__cshperspect-TGF-031989_F1.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:4093, NCBIGene:649, NCBIGene:2657, N...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>PMC5830892__cshperspect-CEL-027961_F2.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:71, NCBIGene:59, NCBIGene:72, NCBIGe...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>PMC5830900__cshperspect-TGF-031997_F1.jpg</td>\n",
       "      <td>{MESH:D011374}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:4093, NCBIGene:649, NCBIGene:6776, N...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>77714</th>\n",
       "      <td>PMC2804790__253_2009_2262_Fig1_HTML.jpg</td>\n",
       "      <td>{MESH:C031105, MESH:D009243, MESH:C018475, MES...</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:124, NCBIGene:127, NCBIGene:131, NCB...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>77715</th>\n",
       "      <td>PMC6332787__thnov09p0126g006.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:8295, NCBIGene:29126, NCBIGene:6387,...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>77716</th>\n",
       "      <td>PMC5807036__IJO-52-03-0787-g01.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:6667, NCBIGene:2313, NCBIGene:285, N...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>77717</th>\n",
       "      <td>PMC6770832__cancers-11-01236-g005.jpg</td>\n",
       "      <td>{}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:4092, NCBIGene:4091, NCBIGene:4093, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>77718</th>\n",
       "      <td>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</td>\n",
       "      <td>{MESH:C029269, MESH:D014443}</td>\n",
       "      <td>{}</td>\n",
       "      <td>{NCBIGene:2065, NCBIGene:1806, NCBIGene:2064, ...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>77719 rows × 4 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                       figure_id  \\\n",
       "0      PMC5732092__cshperspect-CYT-028522_F2.jpg   \n",
       "1      PMC5793760__cshperspect-TGF-022210_F4.jpg   \n",
       "2      PMC5793761__cshperspect-TGF-031989_F1.jpg   \n",
       "3      PMC5830892__cshperspect-CEL-027961_F2.jpg   \n",
       "4      PMC5830900__cshperspect-TGF-031997_F1.jpg   \n",
       "...                                          ...   \n",
       "77714    PMC2804790__253_2009_2262_Fig1_HTML.jpg   \n",
       "77715           PMC6332787__thnov09p0126g006.jpg   \n",
       "77716         PMC5807036__IJO-52-03-0787-g01.jpg   \n",
       "77717      PMC6770832__cancers-11-01236-g005.jpg   \n",
       "77718  PMC4609065__12885_2015_1721_Fig5_HTML.jpg   \n",
       "\n",
       "                                      chemical_curie_set disease_curie_set  \\\n",
       "0                                                     {}                {}   \n",
       "1                                                     {}                {}   \n",
       "2                                                     {}                {}   \n",
       "3                                                     {}                {}   \n",
       "4                                         {MESH:D011374}                {}   \n",
       "...                                                  ...               ...   \n",
       "77714  {MESH:C031105, MESH:D009243, MESH:C018475, MES...                {}   \n",
       "77715                                                 {}                {}   \n",
       "77716                                                 {}                {}   \n",
       "77717                                                 {}                {}   \n",
       "77718                       {MESH:C029269, MESH:D014443}                {}   \n",
       "\n",
       "                                          gene_curie_set  \n",
       "0      {NCBIGene:3326, NCBIGene:5196, NCBIGene:4790, ...  \n",
       "1      {NCBIGene:649, NCBIGene:7046, NCBIGene:653, NC...  \n",
       "2      {NCBIGene:4093, NCBIGene:649, NCBIGene:2657, N...  \n",
       "3      {NCBIGene:71, NCBIGene:59, NCBIGene:72, NCBIGe...  \n",
       "4      {NCBIGene:4093, NCBIGene:649, NCBIGene:6776, N...  \n",
       "...                                                  ...  \n",
       "77714  {NCBIGene:124, NCBIGene:127, NCBIGene:131, NCB...  \n",
       "77715  {NCBIGene:8295, NCBIGene:29126, NCBIGene:6387,...  \n",
       "77716  {NCBIGene:6667, NCBIGene:2313, NCBIGene:285, N...  \n",
       "77717  {NCBIGene:4092, NCBIGene:4091, NCBIGene:4093, ...  \n",
       "77718  {NCBIGene:2065, NCBIGene:1806, NCBIGene:2064, ...  \n",
       "\n",
       "[77719 rows x 4 columns]"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "figures_df_data = []\n",
    "curies_to_figure_ids = {}\n",
    "figure_id_to_curies = {}\n",
    "figure_id_to_pfocr_result = {}\n",
    "for line in pfocr_request.text.splitlines():\n",
    "    pfocr_result = json.loads(line)\n",
    "    figure_id = pfocr_result[\"_id\"]\n",
    "\n",
    "    chemical_curies = set()\n",
    "    disease_curies = set()\n",
    "    gene_curies = set()\n",
    "    for identifier in pfocr_result[\"associatedWith\"][\"mentions\"][\"chemicals\"][\"mesh\"]:\n",
    "        curie = \"MESH:\" + identifier\n",
    "        chemical_curies.add(curie)\n",
    "    for identifier in pfocr_result[\"associatedWith\"][\"mentions\"][\"diseases\"][\"mesh\"]:\n",
    "        curie = \"MESH:\" + identifier\n",
    "        disease_curies.add(curie)\n",
    "    for identifier in pfocr_result[\"associatedWith\"][\"mentions\"][\"genes\"][\"ncbigene\"]:\n",
    "        curie = \"NCBIGene:\" + identifier\n",
    "        gene_curies.add(curie)\n",
    "\n",
    "    figure_id_to_pfocr_result[figure_id] = pfocr_result\n",
    "    figure_id_to_curies[figure_id] = curies\n",
    "\n",
    "    figures_df_data.append({\n",
    "        \"figure_id\": figure_id,\n",
    "        \"chemical_curie_set\": chemical_curies,\n",
    "        \"disease_curie_set\": disease_curies,\n",
    "        \"gene_curie_set\": gene_curies,\n",
    "    })\n",
    "\n",
    "figures_df = pd.DataFrame.from_records(figures_df_data)\n",
    "figures_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [],
   "source": [
    "biolink_category_to_pfocr_category = {\n",
    "    \"biolink:Drug\": \"chemical\",\n",
    "    \"biolink:ChemicalEntity\": \"chemical\",\n",
    "    \"biolink:SmallMolecule\": \"chemical\",\n",
    "    \"biolink:Disease\": \"disease\",\n",
    "    \"biolink:DiseaseOrPhenotypicFeature\": \"disease\",\n",
    "    \"biolink:Gene\": \"gene\",\n",
    "    \"biolink:GeneProduct\": \"gene\",\n",
    "    \"biolink:Protein\": \"gene\",\n",
    "}\n",
    "\n",
    "# limit to categories returned from query\n",
    "relevant_biolink_categories = set(biolink_category_to_pfocr_category.keys()).intersection(curie_categories)\n",
    "relevant_pfocr_categories = set([\n",
    "    biolink_category_to_pfocr_category[\n",
    "        biolink_category\n",
    "    ] for biolink_category in relevant_biolink_categories\n",
    "])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>figure_url</th>\n",
       "      <th>figure_title</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>figure_id</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>PMC5732092__cshperspect-CYT-028522_F2.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...</td>\n",
       "      <td>Interleukin (IL)-17RA/RC signaling pathways</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC5793760__cshperspect-TGF-022210_F4.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...</td>\n",
       "      <td>TGFB signaling pathways</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC5793761__cshperspect-TGF-031989_F1.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...</td>\n",
       "      <td>Bone morphogenetic protein (BMP) signaling pat...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC5830892__cshperspect-CEL-027961_F2.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...</td>\n",
       "      <td>FERM-binding partners of Crumbs3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC5830900__cshperspect-TGF-031997_F1.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...</td>\n",
       "      <td>Role of the TGFB family in mammary gland devel...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC2804790__253_2009_2262_Fig1_HTML.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2...</td>\n",
       "      <td>Ehrlich degradation pathway from amino acid to...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC6332787__thnov09p0126g006.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...</td>\n",
       "      <td>Illustration of the mechanisms underlying LPD ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC5807036__IJO-52-03-0787-g01.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...</td>\n",
       "      <td>Tumorigenic proteins significantly upregulated...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC6770832__cancers-11-01236-g005.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...</td>\n",
       "      <td>Simplified TGFB pathway leading to p21 expression</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</th>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4...</td>\n",
       "      <td>EGFR and ANXA3 to fluoropyrimidine resistance ...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>77719 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                                                                  figure_url  \\\n",
       "figure_id                                                                                      \n",
       "PMC5732092__cshperspect-CYT-028522_F2.jpg  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...   \n",
       "PMC5793760__cshperspect-TGF-022210_F4.jpg  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...   \n",
       "PMC5793761__cshperspect-TGF-031989_F1.jpg  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...   \n",
       "PMC5830892__cshperspect-CEL-027961_F2.jpg  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...   \n",
       "PMC5830900__cshperspect-TGF-031997_F1.jpg  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...   \n",
       "...                                                                                      ...   \n",
       "PMC2804790__253_2009_2262_Fig1_HTML.jpg    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2...   \n",
       "PMC6332787__thnov09p0126g006.jpg           https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...   \n",
       "PMC5807036__IJO-52-03-0787-g01.jpg         https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5...   \n",
       "PMC6770832__cancers-11-01236-g005.jpg      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...   \n",
       "PMC4609065__12885_2015_1721_Fig5_HTML.jpg  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4...   \n",
       "\n",
       "                                                                                figure_title  \n",
       "figure_id                                                                                     \n",
       "PMC5732092__cshperspect-CYT-028522_F2.jpg        Interleukin (IL)-17RA/RC signaling pathways  \n",
       "PMC5793760__cshperspect-TGF-022210_F4.jpg                            TGFB signaling pathways  \n",
       "PMC5793761__cshperspect-TGF-031989_F1.jpg  Bone morphogenetic protein (BMP) signaling pat...  \n",
       "PMC5830892__cshperspect-CEL-027961_F2.jpg                   FERM-binding partners of Crumbs3  \n",
       "PMC5830900__cshperspect-TGF-031997_F1.jpg  Role of the TGFB family in mammary gland devel...  \n",
       "...                                                                                      ...  \n",
       "PMC2804790__253_2009_2262_Fig1_HTML.jpg    Ehrlich degradation pathway from amino acid to...  \n",
       "PMC6332787__thnov09p0126g006.jpg           Illustration of the mechanisms underlying LPD ...  \n",
       "PMC5807036__IJO-52-03-0787-g01.jpg         Tumorigenic proteins significantly upregulated...  \n",
       "PMC6770832__cancers-11-01236-g005.jpg      Simplified TGFB pathway leading to p21 expression  \n",
       "PMC4609065__12885_2015_1721_Fig5_HTML.jpg  EGFR and ANXA3 to fluoropyrimidine resistance ...  \n",
       "\n",
       "[77719 rows x 2 columns]"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "figure_metadata_records = []\n",
    "figure_curie_df_data = []\n",
    "for line in pfocr_request.text.splitlines():\n",
    "    pfocr_result = json.loads(line)\n",
    "    figure_id = pfocr_result[\"_id\"]\n",
    "\n",
    "    chemical_curies = set()\n",
    "    disease_curies = set()\n",
    "    gene_curies = set()\n",
    "    for identifier in pfocr_result[\"associatedWith\"][\"mentions\"][\"chemicals\"][\"mesh\"]:\n",
    "        curie = \"MESH:\" + identifier\n",
    "        chemical_curies.add(curie)\n",
    "        figure_curie_df_data.append({\n",
    "            \"figure_id\": figure_id,\n",
    "            \"curie\": curie,\n",
    "            \"category\": \"chemical\",\n",
    "        })\n",
    "    for identifier in pfocr_result[\"associatedWith\"][\"mentions\"][\"diseases\"][\"mesh\"]:\n",
    "        curie = \"MESH:\" + identifier\n",
    "        disease_curies.add(curie)\n",
    "        figure_curie_df_data.append({\n",
    "            \"figure_id\": figure_id,\n",
    "            \"curie\": curie,\n",
    "            \"category\": \"disease\",\n",
    "        })\n",
    "    for identifier in pfocr_result[\"associatedWith\"][\"mentions\"][\"genes\"][\"ncbigene\"]:\n",
    "        curie = \"NCBIGene:\" + identifier\n",
    "        gene_curies.add(curie)\n",
    "        figure_curie_df_data.append({\n",
    "            \"figure_id\": figure_id,\n",
    "            \"curie\": curie,\n",
    "            \"category\": \"gene\",\n",
    "        })\n",
    "\n",
    "    figure_id_to_pfocr_result[figure_id] = pfocr_result\n",
    "    figure_id_to_curies[figure_id] = curies\n",
    "\n",
    "    figure_metadata_records.append({\n",
    "        \"figure_id\": figure_id,\n",
    "        \"figure_url\": pfocr_result[\"associatedWith\"][\"figureUrl\"],\n",
    "        \"figure_title\": pfocr_result[\"associatedWith\"][\"title\"],\n",
    "    })\n",
    "\n",
    "figure_metadata_df = pd.DataFrame.from_records(figure_metadata_records, index='figure_id')\n",
    "figure_metadata_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>figure_id</th>\n",
       "      <th>curie</th>\n",
       "      <th>category</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>PMC5732092__cshperspect-CYT-028522_F2.jpg</td>\n",
       "      <td>NCBIGene:5601</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>PMC5732092__cshperspect-CYT-028522_F2.jpg</td>\n",
       "      <td>NCBIGene:5595</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>PMC5732092__cshperspect-CYT-028522_F2.jpg</td>\n",
       "      <td>NCBIGene:1051</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>PMC5732092__cshperspect-CYT-028522_F2.jpg</td>\n",
       "      <td>NCBIGene:10131</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>PMC5732092__cshperspect-CYT-028522_F2.jpg</td>\n",
       "      <td>NCBIGene:23765</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1665596</th>\n",
       "      <td>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</td>\n",
       "      <td>NCBIGene:1956</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1665597</th>\n",
       "      <td>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</td>\n",
       "      <td>NCBIGene:4893</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1665598</th>\n",
       "      <td>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</td>\n",
       "      <td>NCBIGene:2064</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1665599</th>\n",
       "      <td>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</td>\n",
       "      <td>NCBIGene:3845</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1665600</th>\n",
       "      <td>PMC4609065__12885_2015_1721_Fig5_HTML.jpg</td>\n",
       "      <td>NCBIGene:306</td>\n",
       "      <td>gene</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>1665601 rows × 3 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                         figure_id           curie category\n",
       "0        PMC5732092__cshperspect-CYT-028522_F2.jpg   NCBIGene:5601     gene\n",
       "1        PMC5732092__cshperspect-CYT-028522_F2.jpg   NCBIGene:5595     gene\n",
       "2        PMC5732092__cshperspect-CYT-028522_F2.jpg   NCBIGene:1051     gene\n",
       "3        PMC5732092__cshperspect-CYT-028522_F2.jpg  NCBIGene:10131     gene\n",
       "4        PMC5732092__cshperspect-CYT-028522_F2.jpg  NCBIGene:23765     gene\n",
       "...                                            ...             ...      ...\n",
       "1665596  PMC4609065__12885_2015_1721_Fig5_HTML.jpg   NCBIGene:1956     gene\n",
       "1665597  PMC4609065__12885_2015_1721_Fig5_HTML.jpg   NCBIGene:4893     gene\n",
       "1665598  PMC4609065__12885_2015_1721_Fig5_HTML.jpg   NCBIGene:2064     gene\n",
       "1665599  PMC4609065__12885_2015_1721_Fig5_HTML.jpg   NCBIGene:3845     gene\n",
       "1665600  PMC4609065__12885_2015_1721_Fig5_HTML.jpg    NCBIGene:306     gene\n",
       "\n",
       "[1665601 rows x 3 columns]"
      ]
     },
     "execution_count": 16,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "figure_curie_df = pd.DataFrame.from_records(figure_curie_df_data)\n",
    "figure_curie_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "Index(['figure_id', 'curie', 'category'], dtype='object')"
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "figure_curie_df.columns"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Clustering"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "tags": []
   },
   "source": [
    "### Identify Cluster Figures\n",
    "\n",
    "See details in write-up at the top."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "number of figures w/ user-specified CURIEs: 209\n",
      "all_relevant_curie_count: 2481\n",
      "i: 0\n",
      "i: 1\n",
      "i: 2\n",
      "i: 3\n",
      "i: 4\n",
      "i: 5\n",
      "i: 6\n",
      "i: 7\n",
      "i: 8\n",
      "i: 9\n",
      "i: 10\n",
      "i: 11\n",
      "i: 12\n",
      "i: 13\n",
      "i: 14\n",
      "i: 15\n",
      "cluster figure count: 24\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>i</th>\n",
       "      <th>figure_id</th>\n",
       "      <th>p_value</th>\n",
       "      <th>next_best_figure_ids</th>\n",
       "      <th>next_best_p_value</th>\n",
       "      <th>yes_trapi_results_yes_figure</th>\n",
       "      <th>yes_trapi_results_no_figure</th>\n",
       "      <th>no_trapi_results_yes_figure</th>\n",
       "      <th>no_trapi_results_no_figure</th>\n",
       "      <th>figure_curies_in_trapi_results</th>\n",
       "      <th>curie_set</th>\n",
       "      <th>curies_to_exclude</th>\n",
       "      <th>len_curies_to_exclude</th>\n",
       "      <th>relevant_figures_unique_curie_count</th>\n",
       "      <th>relevant_figure_count</th>\n",
       "      <th>remaining_trapi_results_unified_curies</th>\n",
       "      <th>cluster_figure_id_count</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0</td>\n",
       "      <td>PMC6878783__OMCL2019-3849692.002.jpg</td>\n",
       "      <td>6.603677e-07</td>\n",
       "      <td>[PMC5923349__cancers-10-00094-g004.jpg]</td>\n",
       "      <td>7.065560e-07</td>\n",
       "      <td>3</td>\n",
       "      <td>1359</td>\n",
       "      <td>31</td>\n",
       "      <td>1088</td>\n",
       "      <td>{MESH:C005948, MESH:D012694, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:71, NCBIGene:70, NCBIGene:72, NCBIGe...</td>\n",
       "      <td>{MESH:C005948, MESH:D012694}</td>\n",
       "      <td>2</td>\n",
       "      <td>2481</td>\n",
       "      <td>209</td>\n",
       "      <td>1362</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>1</td>\n",
       "      <td>PMC5923349__cancers-10-00094-g004.jpg</td>\n",
       "      <td>7.246924e-07</td>\n",
       "      <td>[PMC2871926__rstb20100010-g1.jpg, PMC3729218__...</td>\n",
       "      <td>9.018272e-07</td>\n",
       "      <td>2</td>\n",
       "      <td>1358</td>\n",
       "      <td>42</td>\n",
       "      <td>1079</td>\n",
       "      <td>{NCBIGene:4485, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:50943, NCBIGene:108, NCBIGene:2309, ...</td>\n",
       "      <td>{NCBIGene:4485}</td>\n",
       "      <td>1</td>\n",
       "      <td>2480</td>\n",
       "      <td>208</td>\n",
       "      <td>1360</td>\n",
       "      <td>2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>2</td>\n",
       "      <td>PMC2871926__rstb20100010-g1.jpg</td>\n",
       "      <td>9.034239e-07</td>\n",
       "      <td>[PMC1855036__zmk0050780430011.jpg, PMC3261559_...</td>\n",
       "      <td>9.696647e-07</td>\n",
       "      <td>5</td>\n",
       "      <td>1354</td>\n",
       "      <td>75</td>\n",
       "      <td>1047</td>\n",
       "      <td>{MESH:D009584, NCBIGene:201475, NCBIGene:22931...</td>\n",
       "      <td>{NCBIGene:339122, NCBIGene:11158, NCBIGene:347...</td>\n",
       "      <td>{MESH:D009584, NCBIGene:201475, MESH:D008715, ...</td>\n",
       "      <td>5</td>\n",
       "      <td>2471</td>\n",
       "      <td>207</td>\n",
       "      <td>1359</td>\n",
       "      <td>7</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>2</td>\n",
       "      <td>PMC3729218__nihms419677f4.jpg</td>\n",
       "      <td>9.034239e-07</td>\n",
       "      <td>[PMC1855036__zmk0050780430011.jpg, PMC3261559_...</td>\n",
       "      <td>9.696647e-07</td>\n",
       "      <td>3</td>\n",
       "      <td>1356</td>\n",
       "      <td>77</td>\n",
       "      <td>1045</td>\n",
       "      <td>{NCBIGene:22931, NCBIGene:201475, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:286451, NCBIGene:339122, NCBIGene:11...</td>\n",
       "      <td>{MESH:D009584, NCBIGene:201475, MESH:D008715, ...</td>\n",
       "      <td>5</td>\n",
       "      <td>2471</td>\n",
       "      <td>207</td>\n",
       "      <td>1359</td>\n",
       "      <td>7</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>2</td>\n",
       "      <td>PMC3809539__pc_114736_f5.jpg</td>\n",
       "      <td>9.034239e-07</td>\n",
       "      <td>[PMC1855036__zmk0050780430011.jpg, PMC3261559_...</td>\n",
       "      <td>9.696647e-07</td>\n",
       "      <td>4</td>\n",
       "      <td>1355</td>\n",
       "      <td>76</td>\n",
       "      <td>1046</td>\n",
       "      <td>{MESH:D008715, NCBIGene:22931, NCBIGene:201475...</td>\n",
       "      <td>{NCBIGene:339122, NCBIGene:11158, NCBIGene:347...</td>\n",
       "      <td>{MESH:D009584, NCBIGene:201475, MESH:D008715, ...</td>\n",
       "      <td>5</td>\n",
       "      <td>2471</td>\n",
       "      <td>207</td>\n",
       "      <td>1359</td>\n",
       "      <td>7</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>2</td>\n",
       "      <td>PMC7012187__kpsb-15-01-1703503-g007.jpg</td>\n",
       "      <td>9.034239e-07</td>\n",
       "      <td>[PMC1855036__zmk0050780430011.jpg, PMC3261559_...</td>\n",
       "      <td>9.696647e-07</td>\n",
       "      <td>3</td>\n",
       "      <td>1356</td>\n",
       "      <td>77</td>\n",
       "      <td>1045</td>\n",
       "      <td>{NCBIGene:22931, NCBIGene:201475, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:8655, NCBIGene:22876, NCBIGene:33912...</td>\n",
       "      <td>{MESH:D009584, NCBIGene:201475, MESH:D008715, ...</td>\n",
       "      <td>5</td>\n",
       "      <td>2471</td>\n",
       "      <td>207</td>\n",
       "      <td>1359</td>\n",
       "      <td>7</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>2</td>\n",
       "      <td>PMC7607850__12885_2020_7568_Fig2_HTML.jpg</td>\n",
       "      <td>9.034239e-07</td>\n",
       "      <td>[PMC1855036__zmk0050780430011.jpg, PMC3261559_...</td>\n",
       "      <td>9.696647e-07</td>\n",
       "      <td>3</td>\n",
       "      <td>1356</td>\n",
       "      <td>77</td>\n",
       "      <td>1045</td>\n",
       "      <td>{NCBIGene:22931, NCBIGene:201475, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:339122, NCBIGene:11158, NCBIGene:365...</td>\n",
       "      <td>{MESH:D009584, NCBIGene:201475, MESH:D008715, ...</td>\n",
       "      <td>5</td>\n",
       "      <td>2471</td>\n",
       "      <td>207</td>\n",
       "      <td>1359</td>\n",
       "      <td>7</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>3</td>\n",
       "      <td>PMC1855036__zmk0050780430011.jpg</td>\n",
       "      <td>9.602047e-07</td>\n",
       "      <td>[PMC6273696__molecules-21-00148-g033.jpg]</td>\n",
       "      <td>1.042572e-06</td>\n",
       "      <td>1</td>\n",
       "      <td>1353</td>\n",
       "      <td>72</td>\n",
       "      <td>1055</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:142684, NCBIGene:5864, NCBIGene:5156...</td>\n",
       "      <td>{MESH:D015032, MESH:D002245, MESH:D002118, MES...</td>\n",
       "      <td>4</td>\n",
       "      <td>2439</td>\n",
       "      <td>202</td>\n",
       "      <td>1354</td>\n",
       "      <td>13</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>3</td>\n",
       "      <td>PMC3261559__emboj2011397f8.jpg</td>\n",
       "      <td>9.602047e-07</td>\n",
       "      <td>[PMC6273696__molecules-21-00148-g033.jpg]</td>\n",
       "      <td>1.042572e-06</td>\n",
       "      <td>2</td>\n",
       "      <td>1352</td>\n",
       "      <td>71</td>\n",
       "      <td>1056</td>\n",
       "      <td>{MESH:D015032, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:142684, NCBIGene:5864, NCBIGene:3383...</td>\n",
       "      <td>{MESH:D015032, MESH:D002245, MESH:D002118, MES...</td>\n",
       "      <td>4</td>\n",
       "      <td>2439</td>\n",
       "      <td>202</td>\n",
       "      <td>1354</td>\n",
       "      <td>13</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>3</td>\n",
       "      <td>PMC3504772__zbc0501231830007.jpg</td>\n",
       "      <td>9.602047e-07</td>\n",
       "      <td>[PMC6273696__molecules-21-00148-g033.jpg]</td>\n",
       "      <td>1.042572e-06</td>\n",
       "      <td>2</td>\n",
       "      <td>1352</td>\n",
       "      <td>71</td>\n",
       "      <td>1056</td>\n",
       "      <td>{MESH:D002245, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:142684, NCBIGene:5864, NCBIGene:5156...</td>\n",
       "      <td>{MESH:D015032, MESH:D002245, MESH:D002118, MES...</td>\n",
       "      <td>4</td>\n",
       "      <td>2439</td>\n",
       "      <td>202</td>\n",
       "      <td>1354</td>\n",
       "      <td>13</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>3</td>\n",
       "      <td>PMC4747172__oncotarget-06-41535-g001.jpg</td>\n",
       "      <td>9.602047e-07</td>\n",
       "      <td>[PMC6273696__molecules-21-00148-g033.jpg]</td>\n",
       "      <td>1.042572e-06</td>\n",
       "      <td>2</td>\n",
       "      <td>1352</td>\n",
       "      <td>71</td>\n",
       "      <td>1056</td>\n",
       "      <td>{NCBIGene:5872, MESH:D002784}</td>\n",
       "      <td>{NCBIGene:142684, NCBIGene:5864, NCBIGene:5906...</td>\n",
       "      <td>{MESH:D015032, MESH:D002245, MESH:D002118, MES...</td>\n",
       "      <td>4</td>\n",
       "      <td>2439</td>\n",
       "      <td>202</td>\n",
       "      <td>1354</td>\n",
       "      <td>13</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>3</td>\n",
       "      <td>PMC6356888__cancers-11-00027-g002.jpg</td>\n",
       "      <td>9.602047e-07</td>\n",
       "      <td>[PMC6273696__molecules-21-00148-g033.jpg]</td>\n",
       "      <td>1.042572e-06</td>\n",
       "      <td>2</td>\n",
       "      <td>1352</td>\n",
       "      <td>71</td>\n",
       "      <td>1056</td>\n",
       "      <td>{MESH:D002118, NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:142684, NCBIGene:5864, NCBIGene:3383...</td>\n",
       "      <td>{MESH:D015032, MESH:D002245, MESH:D002118, MES...</td>\n",
       "      <td>4</td>\n",
       "      <td>2439</td>\n",
       "      <td>202</td>\n",
       "      <td>1354</td>\n",
       "      <td>13</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>3</td>\n",
       "      <td>PMC6814454__nihms-1025611-f0003.jpg</td>\n",
       "      <td>9.602047e-07</td>\n",
       "      <td>[PMC6273696__molecules-21-00148-g033.jpg]</td>\n",
       "      <td>1.042572e-06</td>\n",
       "      <td>1</td>\n",
       "      <td>1353</td>\n",
       "      <td>72</td>\n",
       "      <td>1055</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:142684, NCBIGene:5864, NCBIGene:5071...</td>\n",
       "      <td>{MESH:D015032, MESH:D002245, MESH:D002118, MES...</td>\n",
       "      <td>4</td>\n",
       "      <td>2439</td>\n",
       "      <td>202</td>\n",
       "      <td>1354</td>\n",
       "      <td>13</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>4</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>14</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>5</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>15</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>6</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>16</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>7</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>17</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>8</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>18</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>9</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>10</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>20</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>11</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>21</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>12</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>22</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>13</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>23</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>14</td>\n",
       "      <td>PMC4607655__nihms715859f3.jpg</td>\n",
       "      <td>4.699700e-07</td>\n",
       "      <td>[PMC4804636__nihms-715982-f0002.jpg, PMC579095...</td>\n",
       "      <td>8.716236e-07</td>\n",
       "      <td>1</td>\n",
       "      <td>1349</td>\n",
       "      <td>42</td>\n",
       "      <td>1089</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>{NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...</td>\n",
       "      <td>{}</td>\n",
       "      <td>0</td>\n",
       "      <td>2432</td>\n",
       "      <td>196</td>\n",
       "      <td>1350</td>\n",
       "      <td>24</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "     i                                  figure_id       p_value  \\\n",
       "0    0       PMC6878783__OMCL2019-3849692.002.jpg  6.603677e-07   \n",
       "1    1      PMC5923349__cancers-10-00094-g004.jpg  7.246924e-07   \n",
       "2    2            PMC2871926__rstb20100010-g1.jpg  9.034239e-07   \n",
       "3    2              PMC3729218__nihms419677f4.jpg  9.034239e-07   \n",
       "4    2               PMC3809539__pc_114736_f5.jpg  9.034239e-07   \n",
       "5    2    PMC7012187__kpsb-15-01-1703503-g007.jpg  9.034239e-07   \n",
       "6    2  PMC7607850__12885_2020_7568_Fig2_HTML.jpg  9.034239e-07   \n",
       "7    3           PMC1855036__zmk0050780430011.jpg  9.602047e-07   \n",
       "8    3             PMC3261559__emboj2011397f8.jpg  9.602047e-07   \n",
       "9    3           PMC3504772__zbc0501231830007.jpg  9.602047e-07   \n",
       "10   3   PMC4747172__oncotarget-06-41535-g001.jpg  9.602047e-07   \n",
       "11   3      PMC6356888__cancers-11-00027-g002.jpg  9.602047e-07   \n",
       "12   3        PMC6814454__nihms-1025611-f0003.jpg  9.602047e-07   \n",
       "13   4              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "14   5              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "15   6              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "16   7              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "17   8              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "18   9              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "19  10              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "20  11              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "21  12              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "22  13              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "23  14              PMC4607655__nihms715859f3.jpg  4.699700e-07   \n",
       "\n",
       "                                 next_best_figure_ids  next_best_p_value  \\\n",
       "0             [PMC5923349__cancers-10-00094-g004.jpg]       7.065560e-07   \n",
       "1   [PMC2871926__rstb20100010-g1.jpg, PMC3729218__...       9.018272e-07   \n",
       "2   [PMC1855036__zmk0050780430011.jpg, PMC3261559_...       9.696647e-07   \n",
       "3   [PMC1855036__zmk0050780430011.jpg, PMC3261559_...       9.696647e-07   \n",
       "4   [PMC1855036__zmk0050780430011.jpg, PMC3261559_...       9.696647e-07   \n",
       "5   [PMC1855036__zmk0050780430011.jpg, PMC3261559_...       9.696647e-07   \n",
       "6   [PMC1855036__zmk0050780430011.jpg, PMC3261559_...       9.696647e-07   \n",
       "7           [PMC6273696__molecules-21-00148-g033.jpg]       1.042572e-06   \n",
       "8           [PMC6273696__molecules-21-00148-g033.jpg]       1.042572e-06   \n",
       "9           [PMC6273696__molecules-21-00148-g033.jpg]       1.042572e-06   \n",
       "10          [PMC6273696__molecules-21-00148-g033.jpg]       1.042572e-06   \n",
       "11          [PMC6273696__molecules-21-00148-g033.jpg]       1.042572e-06   \n",
       "12          [PMC6273696__molecules-21-00148-g033.jpg]       1.042572e-06   \n",
       "13  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "14  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "15  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "16  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "17  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "18  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "19  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "20  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "21  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "22  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "23  [PMC4804636__nihms-715982-f0002.jpg, PMC579095...       8.716236e-07   \n",
       "\n",
       "    yes_trapi_results_yes_figure  yes_trapi_results_no_figure  \\\n",
       "0                              3                         1359   \n",
       "1                              2                         1358   \n",
       "2                              5                         1354   \n",
       "3                              3                         1356   \n",
       "4                              4                         1355   \n",
       "5                              3                         1356   \n",
       "6                              3                         1356   \n",
       "7                              1                         1353   \n",
       "8                              2                         1352   \n",
       "9                              2                         1352   \n",
       "10                             2                         1352   \n",
       "11                             2                         1352   \n",
       "12                             1                         1353   \n",
       "13                             1                         1349   \n",
       "14                             1                         1349   \n",
       "15                             1                         1349   \n",
       "16                             1                         1349   \n",
       "17                             1                         1349   \n",
       "18                             1                         1349   \n",
       "19                             1                         1349   \n",
       "20                             1                         1349   \n",
       "21                             1                         1349   \n",
       "22                             1                         1349   \n",
       "23                             1                         1349   \n",
       "\n",
       "    no_trapi_results_yes_figure  no_trapi_results_no_figure  \\\n",
       "0                            31                        1088   \n",
       "1                            42                        1079   \n",
       "2                            75                        1047   \n",
       "3                            77                        1045   \n",
       "4                            76                        1046   \n",
       "5                            77                        1045   \n",
       "6                            77                        1045   \n",
       "7                            72                        1055   \n",
       "8                            71                        1056   \n",
       "9                            71                        1056   \n",
       "10                           71                        1056   \n",
       "11                           71                        1056   \n",
       "12                           72                        1055   \n",
       "13                           42                        1089   \n",
       "14                           42                        1089   \n",
       "15                           42                        1089   \n",
       "16                           42                        1089   \n",
       "17                           42                        1089   \n",
       "18                           42                        1089   \n",
       "19                           42                        1089   \n",
       "20                           42                        1089   \n",
       "21                           42                        1089   \n",
       "22                           42                        1089   \n",
       "23                           42                        1089   \n",
       "\n",
       "                       figure_curies_in_trapi_results  \\\n",
       "0         {MESH:C005948, MESH:D012694, NCBIGene:5872}   \n",
       "1                      {NCBIGene:4485, NCBIGene:5872}   \n",
       "2   {MESH:D009584, NCBIGene:201475, NCBIGene:22931...   \n",
       "3    {NCBIGene:22931, NCBIGene:201475, NCBIGene:5872}   \n",
       "4   {MESH:D008715, NCBIGene:22931, NCBIGene:201475...   \n",
       "5    {NCBIGene:22931, NCBIGene:201475, NCBIGene:5872}   \n",
       "6    {NCBIGene:22931, NCBIGene:201475, NCBIGene:5872}   \n",
       "7                                     {NCBIGene:5872}   \n",
       "8                       {MESH:D015032, NCBIGene:5872}   \n",
       "9                       {MESH:D002245, NCBIGene:5872}   \n",
       "10                      {NCBIGene:5872, MESH:D002784}   \n",
       "11                      {MESH:D002118, NCBIGene:5872}   \n",
       "12                                    {NCBIGene:5872}   \n",
       "13                                    {NCBIGene:5872}   \n",
       "14                                    {NCBIGene:5872}   \n",
       "15                                    {NCBIGene:5872}   \n",
       "16                                    {NCBIGene:5872}   \n",
       "17                                    {NCBIGene:5872}   \n",
       "18                                    {NCBIGene:5872}   \n",
       "19                                    {NCBIGene:5872}   \n",
       "20                                    {NCBIGene:5872}   \n",
       "21                                    {NCBIGene:5872}   \n",
       "22                                    {NCBIGene:5872}   \n",
       "23                                    {NCBIGene:5872}   \n",
       "\n",
       "                                            curie_set  \\\n",
       "0   {NCBIGene:71, NCBIGene:70, NCBIGene:72, NCBIGe...   \n",
       "1   {NCBIGene:50943, NCBIGene:108, NCBIGene:2309, ...   \n",
       "2   {NCBIGene:339122, NCBIGene:11158, NCBIGene:347...   \n",
       "3   {NCBIGene:286451, NCBIGene:339122, NCBIGene:11...   \n",
       "4   {NCBIGene:339122, NCBIGene:11158, NCBIGene:347...   \n",
       "5   {NCBIGene:8655, NCBIGene:22876, NCBIGene:33912...   \n",
       "6   {NCBIGene:339122, NCBIGene:11158, NCBIGene:365...   \n",
       "7   {NCBIGene:142684, NCBIGene:5864, NCBIGene:5156...   \n",
       "8   {NCBIGene:142684, NCBIGene:5864, NCBIGene:3383...   \n",
       "9   {NCBIGene:142684, NCBIGene:5864, NCBIGene:5156...   \n",
       "10  {NCBIGene:142684, NCBIGene:5864, NCBIGene:5906...   \n",
       "11  {NCBIGene:142684, NCBIGene:5864, NCBIGene:3383...   \n",
       "12  {NCBIGene:142684, NCBIGene:5864, NCBIGene:5071...   \n",
       "13  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "14  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "15  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "16  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "17  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "18  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "19  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "20  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "21  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "22  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "23  {NCBIGene:100506658, NCBIGene:1495, NCBIGene:7...   \n",
       "\n",
       "                                    curies_to_exclude  len_curies_to_exclude  \\\n",
       "0                        {MESH:C005948, MESH:D012694}                      2   \n",
       "1                                     {NCBIGene:4485}                      1   \n",
       "2   {MESH:D009584, NCBIGene:201475, MESH:D008715, ...                      5   \n",
       "3   {MESH:D009584, NCBIGene:201475, MESH:D008715, ...                      5   \n",
       "4   {MESH:D009584, NCBIGene:201475, MESH:D008715, ...                      5   \n",
       "5   {MESH:D009584, NCBIGene:201475, MESH:D008715, ...                      5   \n",
       "6   {MESH:D009584, NCBIGene:201475, MESH:D008715, ...                      5   \n",
       "7   {MESH:D015032, MESH:D002245, MESH:D002118, MES...                      4   \n",
       "8   {MESH:D015032, MESH:D002245, MESH:D002118, MES...                      4   \n",
       "9   {MESH:D015032, MESH:D002245, MESH:D002118, MES...                      4   \n",
       "10  {MESH:D015032, MESH:D002245, MESH:D002118, MES...                      4   \n",
       "11  {MESH:D015032, MESH:D002245, MESH:D002118, MES...                      4   \n",
       "12  {MESH:D015032, MESH:D002245, MESH:D002118, MES...                      4   \n",
       "13                                                 {}                      0   \n",
       "14                                                 {}                      0   \n",
       "15                                                 {}                      0   \n",
       "16                                                 {}                      0   \n",
       "17                                                 {}                      0   \n",
       "18                                                 {}                      0   \n",
       "19                                                 {}                      0   \n",
       "20                                                 {}                      0   \n",
       "21                                                 {}                      0   \n",
       "22                                                 {}                      0   \n",
       "23                                                 {}                      0   \n",
       "\n",
       "    relevant_figures_unique_curie_count  relevant_figure_count  \\\n",
       "0                                  2481                    209   \n",
       "1                                  2480                    208   \n",
       "2                                  2471                    207   \n",
       "3                                  2471                    207   \n",
       "4                                  2471                    207   \n",
       "5                                  2471                    207   \n",
       "6                                  2471                    207   \n",
       "7                                  2439                    202   \n",
       "8                                  2439                    202   \n",
       "9                                  2439                    202   \n",
       "10                                 2439                    202   \n",
       "11                                 2439                    202   \n",
       "12                                 2439                    202   \n",
       "13                                 2432                    196   \n",
       "14                                 2432                    196   \n",
       "15                                 2432                    196   \n",
       "16                                 2432                    196   \n",
       "17                                 2432                    196   \n",
       "18                                 2432                    196   \n",
       "19                                 2432                    196   \n",
       "20                                 2432                    196   \n",
       "21                                 2432                    196   \n",
       "22                                 2432                    196   \n",
       "23                                 2432                    196   \n",
       "\n",
       "    remaining_trapi_results_unified_curies  cluster_figure_id_count  \n",
       "0                                     1362                        1  \n",
       "1                                     1360                        2  \n",
       "2                                     1359                        7  \n",
       "3                                     1359                        7  \n",
       "4                                     1359                        7  \n",
       "5                                     1359                        7  \n",
       "6                                     1359                        7  \n",
       "7                                     1354                       13  \n",
       "8                                     1354                       13  \n",
       "9                                     1354                       13  \n",
       "10                                    1354                       13  \n",
       "11                                    1354                       13  \n",
       "12                                    1354                       13  \n",
       "13                                    1350                       14  \n",
       "14                                    1350                       15  \n",
       "15                                    1350                       16  \n",
       "16                                    1350                       17  \n",
       "17                                    1350                       18  \n",
       "18                                    1350                       19  \n",
       "19                                    1350                       20  \n",
       "20                                    1350                       21  \n",
       "21                                    1350                       22  \n",
       "22                                    1350                       23  \n",
       "23                                    1350                       24  "
      ]
     },
     "execution_count": 18,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Importing reduce for \n",
    "# rolling computations\n",
    "from functools import reduce\n",
    "  \n",
    "def set_union(series):\n",
    "    return reduce(lambda x, y: x | y, series)\n",
    "\n",
    "def create_set(series):\n",
    "    return set(series.tolist())\n",
    "\n",
    "\n",
    "# TODO: remove cluster_figure_data and its associated DF.\n",
    "# It's just a temporary thing to show what's happening inside.\n",
    "cluster_figure_data = []\n",
    "def get_next_cluster_figures(\n",
    "    all_relevant_curie_count,\n",
    "    remaining_relevant_figure_curie_df,\n",
    "    remaining_trapi_results_unified_curies,\n",
    "    iteration_limit=15,\n",
    "    i=0,\n",
    "    cluster_figure_ids=[],\n",
    "):\n",
    "    print(f'i: {i}')\n",
    "    \n",
    "    relevant_figures_unique_curie_count = len(set(\n",
    "        remaining_relevant_figure_curie_df[\"curie\"].drop_duplicates()\n",
    "    ))\n",
    "    \n",
    "    relevant_figure_count = len(set(\n",
    "        remaining_relevant_figure_curie_df[\"figure_id\"].drop_duplicates()\n",
    "    ))\n",
    "\n",
    "    if (\n",
    "        i >= iteration_limit\n",
    "    ) or (\n",
    "        len(remaining_trapi_results_unified_curies) == 0\n",
    "    ) or (\n",
    "        relevant_figure_count == 0\n",
    "    ):\n",
    "        return cluster_figure_ids\n",
    "    \n",
    "    remaining_figures_df = remaining_relevant_figure_curie_df[\n",
    "        [\"figure_id\", \"curie\"]\n",
    "    ].groupby(\"figure_id\").agg(\n",
    "        create_set\n",
    "    ).rename(columns={\n",
    "        \"curie\": \"curie_set\"\n",
    "    })\n",
    "\n",
    "    remaining_figures_df[\"figure_curie_count\"] = remaining_figures_df[\"curie_set\"].map(len)\n",
    "\n",
    "    remaining_figures_df[\"figure_curies_in_trapi_results\"] = remaining_figures_df[\"curie_set\"].map(\n",
    "        lambda curie_set: remaining_trapi_results_unified_curies.intersection(\n",
    "            set(curie_set)\n",
    "        )\n",
    "    )\n",
    "\n",
    "    # number of CURIEs in both TRAPI results and figure\n",
    "    remaining_figures_df[\"yes_trapi_results_yes_figure\"] = remaining_figures_df[\n",
    "        \"figure_curies_in_trapi_results\"\n",
    "    ].map(len)\n",
    "\n",
    "    # number of CURIEs in TRAPI results but not in figure\n",
    "    remaining_figures_df[\"yes_trapi_results_no_figure\"] = (\n",
    "        len(remaining_trapi_results_unified_curies) -\n",
    "        remaining_figures_df[\"yes_trapi_results_yes_figure\"]\n",
    "    )\n",
    "\n",
    "    # number of CURIEs not in TRAPI results but in figure\n",
    "    remaining_figures_df[\"no_trapi_results_yes_figure\"] = (\n",
    "        remaining_figures_df[\"figure_curie_count\"] -\n",
    "        remaining_figures_df[\"yes_trapi_results_yes_figure\"]\n",
    "    )\n",
    "\n",
    "    # number of CURIEs not in TRAPI results and not in figure,\n",
    "    # ie., number of unique CURIEs only in other figures\n",
    "    remaining_figures_df[\"no_trapi_results_no_figure\"] = (\n",
    "        all_relevant_curie_count -\n",
    "        len(remaining_trapi_results_unified_curies) -\n",
    "        remaining_figures_df[\"no_trapi_results_yes_figure\"]\n",
    "    )\n",
    "\n",
    "    # see https://stackoverflow.com/a/58661068/5354298\n",
    "    _, _, twosided = pvalue_npy(\n",
    "        remaining_figures_df[\"yes_trapi_results_yes_figure\"].to_numpy('uint'),\n",
    "        remaining_figures_df[\"yes_trapi_results_no_figure\"].to_numpy('uint'),\n",
    "        remaining_figures_df[\"no_trapi_results_yes_figure\"].to_numpy('uint'),\n",
    "        remaining_figures_df[\"no_trapi_results_no_figure\"].to_numpy('uint'),\n",
    "    )\n",
    "\n",
    "    remaining_figures_df[\"p_value\"] = pd.Series(twosided, index=remaining_figures_df.index)\n",
    "    remaining_figures_df[\"p_value\"].sort_values()\n",
    "    \n",
    "    min_df = remaining_figures_df[\n",
    "        remaining_figures_df[\"p_value\"] == remaining_figures_df[\"p_value\"].min()\n",
    "    ]\n",
    "        \n",
    "    cluster_figure_ids.extend(min_df.index.tolist())\n",
    "    \n",
    "    # TODO: should we always keep the user-specified CURIE ids?\n",
    "    curies_to_exclude = set(min_df[\"figure_curies_in_trapi_results\"].agg(set_union)) - user_specified_ids\n",
    "    \n",
    "    next_min_df_score = remaining_figures_df[\n",
    "        remaining_figures_df[\"p_value\"] > remaining_figures_df[\"p_value\"].min()\n",
    "    ][\"p_value\"].min()\n",
    "    next_min_df = remaining_figures_df[remaining_figures_df[\"p_value\"] == next_min_df_score]\n",
    "    \n",
    "    for cluster_figure_id, min_row in min_df.iterrows():\n",
    "        cluster_figure_data.append({\n",
    "            \"i\": i,\n",
    "            \"figure_id\": cluster_figure_id,\n",
    "            \"p_value\": min_row[\"p_value\"],\n",
    "            \"next_best_figure_ids\": next_min_df.index.tolist(),\n",
    "            \"next_best_p_value\": next_min_df[\"p_value\"].min(),\n",
    "            \"yes_trapi_results_yes_figure\": min_row[\"yes_trapi_results_yes_figure\"],\n",
    "            \"yes_trapi_results_no_figure\": min_row[\"yes_trapi_results_no_figure\"],\n",
    "            \"no_trapi_results_yes_figure\": min_row[\"no_trapi_results_yes_figure\"],\n",
    "            \"no_trapi_results_no_figure\": min_row[\"no_trapi_results_no_figure\"],\n",
    "            \"figure_curies_in_trapi_results\": min_row[\"figure_curies_in_trapi_results\"],\n",
    "            \"curie_set\": min_row[\"curie_set\"],\n",
    "            \"curies_to_exclude\": curies_to_exclude,\n",
    "            \"len_curies_to_exclude\": len(curies_to_exclude),\n",
    "            \"relevant_figures_unique_curie_count\": relevant_figures_unique_curie_count,\n",
    "            \"relevant_figure_count\": relevant_figure_count,\n",
    "            \"remaining_trapi_results_unified_curies\": len(remaining_trapi_results_unified_curies),\n",
    "            \"cluster_figure_id_count\": len(cluster_figure_ids),\n",
    "        })\n",
    "\n",
    "    if len(curies_to_exclude) == 0:\n",
    "        # On this iteration, failed to match any additional CURIE(s)\n",
    "        # This figure will be excluded, so we'll try again w/ another figure.\n",
    "        next_remaining_relevant_figure_curie_df = remaining_relevant_figure_curie_df\n",
    "    else:\n",
    "        next_remaining_relevant_figure_curie_df = remaining_relevant_figure_curie_df[\n",
    "            (~remaining_relevant_figure_curie_df[\"figure_id\"].isin(\n",
    "                cluster_figure_ids\n",
    "            ))\n",
    "        ]\n",
    "    \n",
    "    return get_next_cluster_figures(\n",
    "        all_relevant_curie_count,\n",
    "        next_remaining_relevant_figure_curie_df,\n",
    "        remaining_trapi_results_unified_curies - curies_to_exclude,\n",
    "        iteration_limit,\n",
    "        i + 1,\n",
    "        cluster_figure_ids,\n",
    "    )\n",
    "\n",
    "\n",
    "# don't worry whether cluster figure has user-specified IDs\n",
    "#relevant_figure_curie_df = figure_curie_df[figure_curie_df[\"category\"].isin(\n",
    "#    list(relevant_pfocr_categories)\n",
    "#)]\n",
    "# only use cluster figures that have the user-specified ids\n",
    "figures_with_user_specified_ids = set(\n",
    "    figure_curie_df[\n",
    "        figure_curie_df[\"curie\"].isin(user_specified_ids)\n",
    "    ][\"figure_id\"]\n",
    ")\n",
    "print(f'number of figures w/ user-specified CURIEs: {len(figures_with_user_specified_ids)}')\n",
    "relevant_figure_curie_df = figure_curie_df[figure_curie_df[\"category\"].isin(\n",
    "    list(relevant_pfocr_categories)\n",
    ") & figure_curie_df[\"figure_id\"].isin(\n",
    "    figures_with_user_specified_ids\n",
    ")]\n",
    "\n",
    "all_relevant_curie_count = len(set(\n",
    "    relevant_figure_curie_df[\"curie\"].drop_duplicates()\n",
    "))\n",
    "print(f'all_relevant_curie_count: {all_relevant_curie_count}')\n",
    "\n",
    "cluster_figure_ids_out = get_next_cluster_figures(\n",
    "    all_relevant_curie_count,\n",
    "    relevant_figure_curie_df,\n",
    "    trapi_results_unified_curies,\n",
    ")\n",
    "print(f'cluster figure count: {len(cluster_figure_ids_out)}')\n",
    "cluster_figure_df = pd.DataFrame.from_records(cluster_figure_data)\n",
    "cluster_figure_df"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Cluster BTE TRAPI Results by Selected PFOCR Figures (Cluster Figures)\n",
    "\n",
    "See details in write-up at the top."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [],
   "source": [
    "figures_df = relevant_figure_curie_df[\n",
    "    relevant_figure_curie_df[\"figure_id\"].isin(set(cluster_figure_df[\"figure_id\"]))\n",
    "][[\"figure_id\", \"curie\"]].groupby(\"figure_id\").agg(\n",
    "    create_set\n",
    ").rename(columns={\n",
    "    \"curie\": \"figure_curie_set\"\n",
    "}).join(\n",
    "    figure_metadata_df\n",
    ").reset_index()\n",
    "\n",
    "figures_df[\"figure_curie_count\"] = figures_df[\"figure_curie_set\"].map(len)\n",
    "\n",
    "figures_df['crossjoin_key'] = 0\n",
    "trapi_results_df['crossjoin_key'] = 0\n",
    "\n",
    "trapi_results_with_figures_df = trapi_results_df.merge(\n",
    "    figures_df, on='crossjoin_key', how='outer'\n",
    ").rename(columns={\n",
    "    \"unified_curie_set\": \"trapi_result_curie_set\"\n",
    "})\n",
    "\n",
    "trapi_results_with_figures_df[\"common_curie_set\"] = trapi_results_with_figures_df.apply(\n",
    "    lambda r: r[\"trapi_result_curie_set\"] & r[\"figure_curie_set\"], axis=1\n",
    ")\n",
    "trapi_results_with_figures_df\n",
    "# number of CURIEs in both TRAPI result and figure\n",
    "# trapi_curies_in_figure\n",
    "# x\n",
    "# Selected & Having the property\n",
    "trapi_results_with_figures_df[\"yes_trapi_result_yes_figure\"] = (\n",
    "    trapi_results_with_figures_df[\"common_curie_set\"].map(len)\n",
    ")\n",
    "\n",
    "# number of CURIEs in TRAPI result but not in figure\n",
    "# q_node_id_count - trapi_curies_in_figure\n",
    "# n - x\n",
    "# Selected & Not Having the property\n",
    "trapi_results_with_figures_df[\"yes_trapi_result_no_figure\"] = (\n",
    "    len(q_node_ids) - trapi_results_with_figures_df[\"yes_trapi_result_yes_figure\"]\n",
    ")\n",
    "\n",
    "# number of CURIEs not in TRAPI result but in figure\n",
    "# curies_in_figure - trapi_curies_in_figure\n",
    "# N - x\n",
    "# Not Selected & Having the property\n",
    "trapi_results_with_figures_df[\"no_trapi_result_yes_figure\"] = (\n",
    "    trapi_results_with_figures_df[\"figure_curie_set\"].map(len) - \n",
    "    trapi_results_with_figures_df[\"yes_trapi_result_yes_figure\"]\n",
    ")\n",
    "\n",
    "# number of CURIEs not in TRAPI result and not in figure,\n",
    "# ie., number of unique CURIEs only in other figures\n",
    "# 28735 - curies_in_figure - q_node_id_count + trapi_curies_in_figure\n",
    "# M - (n + N) + x\n",
    "# Not Selected & Not Having the property\n",
    "trapi_results_with_figures_df[\"no_trapi_result_no_figure\"] = (\n",
    "    all_relevant_curie_count -\n",
    "    trapi_results_with_figures_df[\"figure_curie_set\"].map(len) -\n",
    "    len(q_node_ids) +\n",
    "    trapi_results_with_figures_df[\"yes_trapi_result_yes_figure\"]\n",
    ")\n",
    "\n",
    "# see https://stackoverflow.com/a/58661068/5354298\n",
    "_, _, twosided = pvalue_npy(\n",
    "    trapi_results_with_figures_df[\"yes_trapi_result_yes_figure\"].to_numpy('uint'),\n",
    "    trapi_results_with_figures_df[\"yes_trapi_result_no_figure\"].to_numpy('uint'),\n",
    "    trapi_results_with_figures_df[\"no_trapi_result_yes_figure\"].to_numpy('uint'),\n",
    "    trapi_results_with_figures_df[\"no_trapi_result_no_figure\"].to_numpy('uint'),\n",
    ")\n",
    "\n",
    "trapi_results_with_figures_df[\"p_value\"] = pd.Series(twosided, index=trapi_results_with_figures_df.index)\n",
    "trapi_results_with_figures_df[\"p_value\"].sort_values()\n",
    "\n",
    "# Needed in order to use the TRAPI result CURIEs as a key. A Python Set is not hashable.\n",
    "trapi_results_with_figures_df[\"trapi_result_curies_key\"] = trapi_results_with_figures_df[\n",
    "    \"trapi_result_curie_set\"\n",
    "].map(\n",
    "    lambda x: tuple(sorted(x))\n",
    ")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(array([ 6388.,     0.,     0.,     0.,  6116., 11981.,     0.,     0.,\n",
       "            0., 61335.]),\n",
       " array([2.44657613e-05, 9.39062144e-03, 1.87567771e-02, 2.81229328e-02,\n",
       "        3.74890885e-02, 4.68552442e-02, 5.62213998e-02, 6.55875555e-02,\n",
       "        7.49537112e-02, 8.43198669e-02, 9.36860225e-02]),\n",
       " <BarContainer object of 10 artists>)"
      ]
     },
     "execution_count": 20,
     "metadata": {},
     "output_type": "execute_result"
    },
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "plt.hist(trapi_results_with_figures_df[\"p_value\"])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## View TRAPI Results by PFOCR Figure"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>n0</th>\n",
       "      <th>e0</th>\n",
       "      <th>n1</th>\n",
       "      <th>e1</th>\n",
       "      <th>n2</th>\n",
       "      <th>n0_original_curie</th>\n",
       "      <th>n0_unified_curie</th>\n",
       "      <th>n1_original_curie</th>\n",
       "      <th>n1_unified_curie</th>\n",
       "      <th>n2_original_curie</th>\n",
       "      <th>...</th>\n",
       "      <th>figure_url</th>\n",
       "      <th>figure_title</th>\n",
       "      <th>figure_curie_count</th>\n",
       "      <th>common_curie_set</th>\n",
       "      <th>yes_trapi_result_yes_figure</th>\n",
       "      <th>yes_trapi_result_no_figure</th>\n",
       "      <th>no_trapi_result_yes_figure</th>\n",
       "      <th>no_trapi_result_no_figure</th>\n",
       "      <th>p_value</th>\n",
       "      <th>trapi_result_curies_key</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>1225</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>RAB18</td>\n",
       "      <td>entity_negatively_regulated_by_entity</td>\n",
       "      <td>Cholesterol</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>NCBIGene:22931</td>\n",
       "      <td>PUBCHEM.COMPOUND:5997</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4...</td>\n",
       "      <td>Mechanisms for autophagy modulation by isopren...</td>\n",
       "      <td>73</td>\n",
       "      <td>{NCBIGene:22931, MESH:D002784, NCBIGene:5872}</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>70</td>\n",
       "      <td>2408</td>\n",
       "      <td>0.000024</td>\n",
       "      <td>(MESH:D002784, NCBIGene:22931, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17553</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_negatively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>entity_positively_regulated_by_entity</td>\n",
       "      <td>Serine</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:5951</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...</td>\n",
       "      <td>Astaxanthin improves insulin sensitivity and g...</td>\n",
       "      <td>34</td>\n",
       "      <td>{MESH:D012694, NCBIGene:5872}</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>32</td>\n",
       "      <td>2446</td>\n",
       "      <td>0.000542</td>\n",
       "      <td>(MESH:D012694, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17511</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>entity_negatively_regulated_by_entity</td>\n",
       "      <td>Serine</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:5951</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...</td>\n",
       "      <td>Astaxanthin improves insulin sensitivity and g...</td>\n",
       "      <td>34</td>\n",
       "      <td>{MESH:D012694, NCBIGene:5872}</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>32</td>\n",
       "      <td>2446</td>\n",
       "      <td>0.000542</td>\n",
       "      <td>(MESH:D012694, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17525</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>entity_positively_regulated_by_entity</td>\n",
       "      <td>Serine</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:5951</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...</td>\n",
       "      <td>Astaxanthin improves insulin sensitivity and g...</td>\n",
       "      <td>34</td>\n",
       "      <td>{MESH:D012694, NCBIGene:5872}</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>32</td>\n",
       "      <td>2446</td>\n",
       "      <td>0.000542</td>\n",
       "      <td>(MESH:D012694, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>63487</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>SMAD4</td>\n",
       "      <td>entity_negatively_regulated_by_entity</td>\n",
       "      <td>Serine</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:4089</td>\n",
       "      <td>NCBIGene:4089</td>\n",
       "      <td>PUBCHEM.COMPOUND:5951</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...</td>\n",
       "      <td>Astaxanthin improves insulin sensitivity and g...</td>\n",
       "      <td>34</td>\n",
       "      <td>{MESH:D012694, NCBIGene:5872}</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>32</td>\n",
       "      <td>2446</td>\n",
       "      <td>0.000542</td>\n",
       "      <td>(MESH:D012694, NCBIGene:4089, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41103</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_negatively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>coexists_with</td>\n",
       "      <td>Sodium alginate</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:5102882</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7...</td>\n",
       "      <td>ZA inhibits mevalonate pathway</td>\n",
       "      <td>80</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>79</td>\n",
       "      <td>2399</td>\n",
       "      <td>0.093686</td>\n",
       "      <td>(MESH:D000464, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41105</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>interacts_with</td>\n",
       "      <td>beta-D-Fructofuranosyl alpha-D-glucopyranoside</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:91692850</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2...</td>\n",
       "      <td>Model describing the movement of preleptotene ...</td>\n",
       "      <td>80</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>79</td>\n",
       "      <td>2399</td>\n",
       "      <td>0.093686</td>\n",
       "      <td>(MESH:D000073893, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41108</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_positively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>interacts_with</td>\n",
       "      <td>beta-D-Fructofuranosyl alpha-D-glucopyranoside</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:91692850</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3...</td>\n",
       "      <td>Mutations causing susceptibility to intestinal...</td>\n",
       "      <td>80</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>79</td>\n",
       "      <td>2399</td>\n",
       "      <td>0.093686</td>\n",
       "      <td>(MESH:D000073893, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>40948</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>entity_negatively_regulates_entity</td>\n",
       "      <td>INS</td>\n",
       "      <td>coexists_with</td>\n",
       "      <td>Lipopolysaccharide</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>NCBIGene:3630</td>\n",
       "      <td>PUBCHEM.COMPOUND:11970143</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7...</td>\n",
       "      <td>Simplified model summarizing the effect of OSR...</td>\n",
       "      <td>80</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>79</td>\n",
       "      <td>2399</td>\n",
       "      <td>0.093686</td>\n",
       "      <td>(MESH:D008070, NCBIGene:3630, NCBIGene:5872)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>85819</th>\n",
       "      <td>RAB13</td>\n",
       "      <td>genetically_interacts_with</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>coexists_with</td>\n",
       "      <td>Progesterone</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:5872</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>NCBIGene:7046</td>\n",
       "      <td>PUBCHEM.COMPOUND:5994</td>\n",
       "      <td>...</td>\n",
       "      <td>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7...</td>\n",
       "      <td>ZA inhibits mevalonate pathway</td>\n",
       "      <td>80</td>\n",
       "      <td>{NCBIGene:5872}</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>79</td>\n",
       "      <td>2399</td>\n",
       "      <td>0.093686</td>\n",
       "      <td>(MESH:D011374, NCBIGene:5872, NCBIGene:7046)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>85820 rows × 25 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "          n0                                  e0      n1  \\\n",
       "1225   RAB13  entity_positively_regulates_entity   RAB18   \n",
       "17553  RAB13  entity_negatively_regulates_entity     INS   \n",
       "17511  RAB13  entity_positively_regulates_entity     INS   \n",
       "17525  RAB13  entity_positively_regulates_entity     INS   \n",
       "63487  RAB13          genetically_interacts_with   SMAD4   \n",
       "...      ...                                 ...     ...   \n",
       "41103  RAB13  entity_negatively_regulates_entity     INS   \n",
       "41105  RAB13  entity_positively_regulates_entity     INS   \n",
       "41108  RAB13  entity_positively_regulates_entity     INS   \n",
       "40948  RAB13  entity_negatively_regulates_entity     INS   \n",
       "85819  RAB13          genetically_interacts_with  TGFBR1   \n",
       "\n",
       "                                          e1  \\\n",
       "1225   entity_negatively_regulated_by_entity   \n",
       "17553  entity_positively_regulated_by_entity   \n",
       "17511  entity_negatively_regulated_by_entity   \n",
       "17525  entity_positively_regulated_by_entity   \n",
       "63487  entity_negatively_regulated_by_entity   \n",
       "...                                      ...   \n",
       "41103                          coexists_with   \n",
       "41105                         interacts_with   \n",
       "41108                         interacts_with   \n",
       "40948                          coexists_with   \n",
       "85819                          coexists_with   \n",
       "\n",
       "                                                   n2 n0_original_curie  \\\n",
       "1225                                      Cholesterol     NCBIGene:5872   \n",
       "17553                                          Serine     NCBIGene:5872   \n",
       "17511                                          Serine     NCBIGene:5872   \n",
       "17525                                          Serine     NCBIGene:5872   \n",
       "63487                                          Serine     NCBIGene:5872   \n",
       "...                                               ...               ...   \n",
       "41103                                 Sodium alginate     NCBIGene:5872   \n",
       "41105  beta-D-Fructofuranosyl alpha-D-glucopyranoside     NCBIGene:5872   \n",
       "41108  beta-D-Fructofuranosyl alpha-D-glucopyranoside     NCBIGene:5872   \n",
       "40948                              Lipopolysaccharide     NCBIGene:5872   \n",
       "85819                                    Progesterone     NCBIGene:5872   \n",
       "\n",
       "      n0_unified_curie n1_original_curie n1_unified_curie  \\\n",
       "1225     NCBIGene:5872    NCBIGene:22931   NCBIGene:22931   \n",
       "17553    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "17511    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "17525    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "63487    NCBIGene:5872     NCBIGene:4089    NCBIGene:4089   \n",
       "...                ...               ...              ...   \n",
       "41103    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "41105    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "41108    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "40948    NCBIGene:5872     NCBIGene:3630    NCBIGene:3630   \n",
       "85819    NCBIGene:5872     NCBIGene:7046    NCBIGene:7046   \n",
       "\n",
       "               n2_original_curie  ...  \\\n",
       "1225       PUBCHEM.COMPOUND:5997  ...   \n",
       "17553      PUBCHEM.COMPOUND:5951  ...   \n",
       "17511      PUBCHEM.COMPOUND:5951  ...   \n",
       "17525      PUBCHEM.COMPOUND:5951  ...   \n",
       "63487      PUBCHEM.COMPOUND:5951  ...   \n",
       "...                          ...  ...   \n",
       "41103   PUBCHEM.COMPOUND:5102882  ...   \n",
       "41105  PUBCHEM.COMPOUND:91692850  ...   \n",
       "41108  PUBCHEM.COMPOUND:91692850  ...   \n",
       "40948  PUBCHEM.COMPOUND:11970143  ...   \n",
       "85819      PUBCHEM.COMPOUND:5994  ...   \n",
       "\n",
       "                                              figure_url  \\\n",
       "1225   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4...   \n",
       "17553  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...   \n",
       "17511  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...   \n",
       "17525  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...   \n",
       "63487  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6...   \n",
       "...                                                  ...   \n",
       "41103  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7...   \n",
       "41105  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2...   \n",
       "41108  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3...   \n",
       "40948  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7...   \n",
       "85819  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7...   \n",
       "\n",
       "                                            figure_title  figure_curie_count  \\\n",
       "1225   Mechanisms for autophagy modulation by isopren...                  73   \n",
       "17553  Astaxanthin improves insulin sensitivity and g...                  34   \n",
       "17511  Astaxanthin improves insulin sensitivity and g...                  34   \n",
       "17525  Astaxanthin improves insulin sensitivity and g...                  34   \n",
       "63487  Astaxanthin improves insulin sensitivity and g...                  34   \n",
       "...                                                  ...                 ...   \n",
       "41103                     ZA inhibits mevalonate pathway                  80   \n",
       "41105  Model describing the movement of preleptotene ...                  80   \n",
       "41108  Mutations causing susceptibility to intestinal...                  80   \n",
       "40948  Simplified model summarizing the effect of OSR...                  80   \n",
       "85819                     ZA inhibits mevalonate pathway                  80   \n",
       "\n",
       "                                    common_curie_set  \\\n",
       "1225   {NCBIGene:22931, MESH:D002784, NCBIGene:5872}   \n",
       "17553                  {MESH:D012694, NCBIGene:5872}   \n",
       "17511                  {MESH:D012694, NCBIGene:5872}   \n",
       "17525                  {MESH:D012694, NCBIGene:5872}   \n",
       "63487                  {MESH:D012694, NCBIGene:5872}   \n",
       "...                                              ...   \n",
       "41103                                {NCBIGene:5872}   \n",
       "41105                                {NCBIGene:5872}   \n",
       "41108                                {NCBIGene:5872}   \n",
       "40948                                {NCBIGene:5872}   \n",
       "85819                                {NCBIGene:5872}   \n",
       "\n",
       "      yes_trapi_result_yes_figure yes_trapi_result_no_figure  \\\n",
       "1225                            3                          0   \n",
       "17553                           2                          1   \n",
       "17511                           2                          1   \n",
       "17525                           2                          1   \n",
       "63487                           2                          1   \n",
       "...                           ...                        ...   \n",
       "41103                           1                          2   \n",
       "41105                           1                          2   \n",
       "41108                           1                          2   \n",
       "40948                           1                          2   \n",
       "85819                           1                          2   \n",
       "\n",
       "      no_trapi_result_yes_figure  no_trapi_result_no_figure   p_value  \\\n",
       "1225                          70                       2408  0.000024   \n",
       "17553                         32                       2446  0.000542   \n",
       "17511                         32                       2446  0.000542   \n",
       "17525                         32                       2446  0.000542   \n",
       "63487                         32                       2446  0.000542   \n",
       "...                          ...                        ...       ...   \n",
       "41103                         79                       2399  0.093686   \n",
       "41105                         79                       2399  0.093686   \n",
       "41108                         79                       2399  0.093686   \n",
       "40948                         79                       2399  0.093686   \n",
       "85819                         79                       2399  0.093686   \n",
       "\n",
       "                               trapi_result_curies_key  \n",
       "1225     (MESH:D002784, NCBIGene:22931, NCBIGene:5872)  \n",
       "17553     (MESH:D012694, NCBIGene:3630, NCBIGene:5872)  \n",
       "17511     (MESH:D012694, NCBIGene:3630, NCBIGene:5872)  \n",
       "17525     (MESH:D012694, NCBIGene:3630, NCBIGene:5872)  \n",
       "63487     (MESH:D012694, NCBIGene:4089, NCBIGene:5872)  \n",
       "...                                                ...  \n",
       "41103     (MESH:D000464, NCBIGene:3630, NCBIGene:5872)  \n",
       "41105  (MESH:D000073893, NCBIGene:3630, NCBIGene:5872)  \n",
       "41108  (MESH:D000073893, NCBIGene:3630, NCBIGene:5872)  \n",
       "40948     (MESH:D008070, NCBIGene:3630, NCBIGene:5872)  \n",
       "85819     (MESH:D011374, NCBIGene:5872, NCBIGene:7046)  \n",
       "\n",
       "[85820 rows x 25 columns]"
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# This isn't really a significance threshold. It's more just intended to\n",
    "# exclude results where the p-value is 1 or very close to it.\n",
    "threshold = 0.9\n",
    "significant_trapi_results_with_figures_df = trapi_results_with_figures_df[\n",
    "    trapi_results_with_figures_df[\"p_value\"] < 0.9\n",
    "]\n",
    "\n",
    "# all\n",
    "cooccurrence_df = significant_trapi_results_with_figures_df.sort_values(\n",
    "    \"p_value\"\n",
    ")\n",
    "\n",
    "### first and any other query node\n",
    "##q_node_id_combination = (q_node_ids[0],)\n",
    "\n",
    "## first and second query nodes\n",
    "##q_node_id_combination = (q_node_ids[0], q_node_ids[1])\n",
    "\n",
    "### first and last query nodes\n",
    "##q_node_id_combination = (q_node_ids[0], q_node_ids[-1])\n",
    "\n",
    "### second and last query nodes\n",
    "##q_node_id_combination = (q_node_ids[1], q_node_ids[-1])\n",
    "\n",
    "### every query node with 'ids' specified\n",
    "##q_node_id_combination = query_nodes_with_ids\n",
    "\n",
    "#print(f'{\" & \".join(q_node_id_combination)}')\n",
    "#s = pd.Series(\n",
    "#    [True] * len(significant_trapi_results_with_figures_df),\n",
    "#    index=significant_trapi_results_with_figures_dfindex\n",
    "#)\n",
    "#for q_node_id in q_node_id_combination:\n",
    "#    s = s & significant_trapi_results_with_figures_df.apply(\n",
    "#        lambda r: r[f'{q_node_id}_unified_curie'] in r[\"common_curie_set\"], axis=1\n",
    "#    )\n",
    "#cooccurrence_df = significant_trapi_results_with_figures_df[s == True].sort_values(\n",
    "#    \"p_value\"\n",
    "#)\n",
    "\n",
    "cooccurrence_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747172/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747172/bin/oncotarget-06-41535-g001.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:22931, MESH:D002784\n",
       "    </span> \n",
       "    (p-value: 2.4e-05)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB18</span>\n",
       " - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Cholesterol</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C512195\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D003561\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C515233\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000714967\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C554092\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D005472\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C522973\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C527797\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D000068196\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878783/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878783/bin/OMCL2019-3849692.002.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Astaxanthin improves insulin sensitivity and glucose uptake\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
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    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:3630, MESH:D012694\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4089, MESH:D012694\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - SMAD4 - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:7316, MESH:C005948\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - UBC - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Astaxanthin</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - UBC - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Astaxanthin</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:D012694\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - MST1 - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - MST1 - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:7316, MESH:D012694\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - UBC - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - UBC - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:7046, MESH:D012694\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - TGFBR1 - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:6789, MESH:D012694\n",
       "    </span> \n",
       "    (p-value: 5.4e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - STK4 - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - STK4 - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Serine</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4089, MESH:C532162\n",
       "    </span> \n",
       "    (p-value: 4.1e-02)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - SMAD4 - associated_with_resistance_to - Pictilisib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - genetically_interacts_with - SMAD4 - associated_with_sensitivity_to - Pictilisib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:3630, MESH:D011374\n",
       "    </span> \n",
       "    (p-value: 4.1e-02)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_positively_regulated_by_entity - Progesterone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_negatively_regulated_by_entity - Progesterone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_negatively_regulated_by_entity - Progesterone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_positively_regulated_by_entity - Progesterone</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:3630, MESH:C585539\n",
       "    </span> \n",
       "    (p-value: 4.1e-02)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_positively_regulated_by_entity - Alpelisib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_negatively_regulated_by_entity - Alpelisib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_positively_regulated_by_entity - Alpelisib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_negatively_regulated_by_entity - Alpelisib</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923349/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923349/bin/cancers-10-00094-g004.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Leukocyte-intrinsic Hippo pathway functions\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
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    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C473711\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:D008550\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - entity_positively_regulated_by_entity - Melatonin</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - entity_negatively_regulated_by_entity - Melatonin</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C582670\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - Alectinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:D005944\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - entity_negatively_regulated_by_entity - D-Glucosamine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C540576\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_sensitivity_to - 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C506269\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_sensitivity_to - 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C508757\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - Ispinesib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C010945\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - Embelin</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_sensitivity_to - Embelin</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:D020097\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - entity_negatively_regulated_by_entity - H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys(1)-Phe-Gly-Arg-Cys(1)-Gly-Leu-Gly-Ser-Ser-Ser-Ser-Ile-Arg-Asp-Met-Lys-Lys-Val-Leu-Arg-Arg-His-OH</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:4485, MESH:C000706872\n",
       "    </span> \n",
       "    (p-value: 9.1e-04)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">MST1</span>\n",
       " - associated_with_resistance_to - N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814454/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814454/bin/nihms-1025611-f0003.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Substrates of PD enzymes identified by proteomics.(A) The PINK1-parkin mitophagy pathway\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
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     "metadata": {},
     "output_type": "display_data"
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    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C515233\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D003561\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C512195\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D005472\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C554092\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C527797\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C522973\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000714967\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D000068196\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C471109\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - BMS-345541 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - BMS-345541 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - BMS-345541 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - BMS-345541 free base</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504772/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504772/bin/zbc0501231830007.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Proposed mechanism for the spatiotemporal regulation of Rabex-5 in the endocytic trafficking of ubiquitinated L1\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C512195\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:3630, MESH:D002245\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Carbon dioxide</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - INS - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Carbon dioxide</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_positively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Carbon dioxide</span>\n",
       "</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - INS - entity_negatively_regulated_by_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">Carbon dioxide</span>\n",
       "</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000714967\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D003561\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C515233\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C522973\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C554092\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D005472\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C527797\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D000068196\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855036/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855036/bin/zmk0050780430011.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Working model for the caveolin-dependent trafficking of M1 muscarinic receptor\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D003561\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C512195\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C515233\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000714967\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C579675\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C522973\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C554092\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D005472\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C527797\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D000068196\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261559/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261559/bin/emboj2011397f8.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            The regulatory function of UBD-GEF proteins auto-ubiquitylation\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
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     "metadata": {},
     "output_type": "display_data"
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    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000714967\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C512195\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D003561\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C515233\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C522973\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D005472\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C554092\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C527797\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C532254\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D000068196\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356888/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356888/bin/cancers-11-00027-g002.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            TRPML1-3 and TPC1-2 in the endocytic pathway\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D003561\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Cytarabine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Cytarabine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C512195\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Elesclomol</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000714967\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - OBATOCLAX MESYLATE</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C515233\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Saracatinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D005472\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-Fluorouracil</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-Fluorouracil</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C554092\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Avagacestat</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Avagacestat</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C522973\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PI-103</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - PI-103</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C527797\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - PF-00562271 free base</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D000068196\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Paclitaxel</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Paclitaxel</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C471109\n",
       "    </span> \n",
       "    (p-value: 2.5e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - BMS-345541 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - BMS-345541 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - BMS-345541 free base</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - BMS-345541 free base</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607850/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607850/bin/12885_2020_7568_Fig2_HTML.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            ZA inhibits mevalonate pathway\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C544967\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Quizartinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Quizartinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Quizartinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Quizartinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C003724\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - S-Trityl-L-cysteine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - S-Trityl-L-cysteine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - S-Trityl-L-cysteine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - S-Trityl-L-cysteine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C524135\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000710356\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000706872\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C561695\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - (S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - (S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D002166\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Camptothecin</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Camptothecin</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C544308\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C040947\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Dimethyloxalylglycine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Dimethyloxalylglycine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Dimethyloxalylglycine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Dimethyloxalylglycine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C528327\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Fedratinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Fedratinib</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
       "    <figure style=\"margin: 5px !important;\">\n",
       "        <a target=\"_blank\" href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871926/\">\n",
       "          <img src=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871926/bin/rstb20100010-g1.jpg\" style=\"max-height: 500px; max-width: 100%;\">\n",
       "        </a>\n",
       "        <br>\n",
       "        <caption>\n",
       "            Model describing the movement of preleptotene spermatocytes across the BTB\n",
       "        </caption>\n",
       "    </figure>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000604219\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C544967\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Quizartinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Quizartinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Quizartinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Quizartinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C003724\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - S-Trityl-L-cysteine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - S-Trityl-L-cysteine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - S-Trityl-L-cysteine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - S-Trityl-L-cysteine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C524135\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:D002166\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Camptothecin</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Camptothecin</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000710356\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C528327\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Fedratinib</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Fedratinib</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C000706872\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C040947\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Dimethyloxalylglycine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_sensitivity_to - Dimethyloxalylglycine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Dimethyloxalylglycine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - Dimethyloxalylglycine</span>\n",
       "</div>\n",
       "<br>\n",
       "<div>\n",
       "    <span style=\"font-weight: bold; font-size: small;\">\n",
       "        TRAPI result NCBIGene:5872, NCBIGene:201475, MESH:C510150\n",
       "    </span> \n",
       "    (p-value: 3.0e-03)\n",
       "    <br>\n",
       "    \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_negatively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine</span><br>\n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB13</span>\n",
       " - entity_positively_regulates_entity - \n",
       "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">RAB12</span>\n",
       " - associated_with_resistance_to - 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine</span>\n",
       "</div>\n"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "...\n",
      "\n",
      "plus 3148 more TRAPI results\n",
      "\n",
      "...\n",
      "\n",
      "\n",
      "plus 4 more figures, each with TRAPI results\n",
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "from IPython.display import Image\n",
    "from IPython.core.display import HTML \n",
    "\n",
    "\n",
    "outer_limit = 10\n",
    "inner_limit = 10\n",
    "\n",
    "count = 0\n",
    "for figure_id, one_figure_id_df in cooccurrence_df.groupby(\"figure_id\", sort=False):\n",
    "    [pmc,filename] = figure_id.split(\"__\")\n",
    "    paper_url = f\"https://www.ncbi.nlm.nih.gov/pmc/articles/{pmc}/\"\n",
    "    figure_url = f\"https://www.ncbi.nlm.nih.gov/pmc/articles/{pmc}/bin/{filename}\"\n",
    "    figure_title = list(set(one_figure_id_df[\"figure_title\"]))[0]\n",
    "\n",
    "    display(HTML(data=f'''\n",
    "<div style=\"border: 1px solid slategray; padding: 6px;\">\n",
    "    <figure style=\"margin: 5px !important;\">\n",
    "        <a target=\"_blank\" href=\"{paper_url}\">\n",
    "          <img src=\"{figure_url}\" style=\"max-height: 500px; max-width: 100%;\">\n",
    "        </a>\n",
    "        <br>\n",
    "        <caption>\n",
    "            {figure_title}\n",
    "        </caption>\n",
    "    </figure>\n",
    "</div>\n",
    "'''))\n",
    "\n",
    "    trapi_results_row_sets = []\n",
    "    \n",
    "    for trapi_result_curie_combo, one_trapi_result_curie_combo_df in one_figure_id_df[(\n",
    "        trapi_result_columns +\n",
    "        unified_curie_columns +\n",
    "        [\"trapi_result_curies_key\", \"common_curie_set\", \"p_value\"]\n",
    "    )].groupby(\"trapi_result_curies_key\", sort=False):\n",
    "        overlap_names = []\n",
    "        for curie in one_trapi_result_curie_combo_df[\"common_curie_set\"].tolist()[0]:\n",
    "            name = curie_to_name[curie]\n",
    "            overlap_names.append(name)\n",
    "\n",
    "        trapi_results_rows = []\n",
    "        for i,row in one_trapi_result_curie_combo_df.iterrows():\n",
    "            trapi_result_chunks = []\n",
    "            for trapi_result_column in trapi_result_columns:\n",
    "                row_value = row[trapi_result_column]\n",
    "                if row_value in overlap_names:\n",
    "                    trapi_result_chunk = f'''\n",
    "<span style=\"border: 1px orange solid; padding: 1px; border-radius: 4px;\">{row_value}</span>\n",
    "'''\n",
    "                else:\n",
    "                    trapi_result_chunk = f'{row_value}'\n",
    "                trapi_result_chunks.append(trapi_result_chunk)\n",
    "                \n",
    "            trapi_results_rows.append(\n",
    "                f'{\" - \".join(trapi_result_chunks)}</span>'\n",
    "            )\n",
    "        \n",
    "        ordered_trapi_result_curie_combo = []\n",
    "        for unified_curie_column in unified_curie_columns:\n",
    "            ordered_trapi_result_curie_combo.append(list(set(\n",
    "                one_trapi_result_curie_combo_df[unified_curie_column]\n",
    "            ))[0])\n",
    "        \n",
    "        p_value = list(set(one_trapi_result_curie_combo_df[\"p_value\"]))[0]\n",
    "        trapi_results_row_sets.append(f'''\n",
    "<div>\n",
    "    <span style=\"font-weight: bold; font-size: small;\">\n",
    "        TRAPI result {\", \".join(ordered_trapi_result_curie_combo)}\n",
    "    </span> \n",
    "    (p-value: {p_value:.1e})\n",
    "    <br>\n",
    "    {\"<br>\".join(trapi_results_rows)}\n",
    "</div>\n",
    "''')\n",
    "\n",
    "    trapi_results_row_set_count = len(trapi_results_row_sets)\n",
    "    display(HTML(data=\"<br>\".join(trapi_results_row_sets[:inner_limit])))\n",
    "    if trapi_results_row_set_count > inner_limit:\n",
    "        print(f\"...\")\n",
    "        print(\"\")\n",
    "        print(f\"plus {trapi_results_row_set_count - inner_limit} more TRAPI results\")\n",
    "    print(\"\")\n",
    "\n",
    "    count += 1\n",
    "    if count >= outer_limit:\n",
    "        print(\"...\")\n",
    "        print(\"\")\n",
    "        print(f'''\n",
    "plus {len(set(cooccurrence_df[\"figure_id\"])) - outer_limit} more figures, each with TRAPI results\n",
    "''')\n",
    "        print(\"\")\n",
    "        break"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
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   "name": "bte_clustering.ipynb",
   "provenance": []
  },
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