This folder contains datasets generated by the repository.

OFFSIDES

offsides/offsides_all_adverse_event_samples.tsv contains generated positive/negative samples for 1,227 adverse events.
offsides/offsides_all_adverse_event_drugs.txt contains names of 2,728 drugs involved in the 1,227 adverse events.
offsides/offsides_all_adverse_event_summary.tsv contains a summary of sample size for the 1,227 adverse events.

tox21/tox21_assay_samples_all.tsv contains generated active/inactive samples for 59 toxicity assays from Tox21. tox21/tox21_assay_samples.tsv contains generated data for 16 toxicity assays with more than 500 active/inactive samples.
tox21/tox21_10k_library_atc_code.tsv contains ATC classification code of compounds in the Tox21 library.

LiverTox/dili_phenotype_terms.tsv contains 20 adverse event terms from OFFSIDES that are associated with drug-induced liver injury (DILI).
LiverTox/dili_phenotype_tox21_compounds.tsv contains Tox21 compounds associated with the 20 DILI events extracted from OFFSIDES.
LiverTox/dili_phenotype_dsstox_compounds.tsv contains DSSTox compounds associated with the 20 DILI events extracted from OFFSIDES.
LiverTox/dili_phenotype_tox21-rt-viability-hepg2-p1_association.tsv contains computed association odds ratio between Tox21 HepG2 Cell viability phenotype and 20 DILI phenotypes extracted from OFFSIDES.

KidneyTox/diki_phenotype_terms.tsv contains 24 adverse event terms from OFFSIDES that are associated with drug-induced kidney injury (DIKI).
KidneyTox/KidneyTox/diki_phenotype_tox21_compounds.tsv contains Tox21 compounds associated with the 24 DIKI events extracted from OFFSIDES.
KidneyTox/diki_phenotype_dsstox_compounds.tsv contains DSSTox compounds associated with the 24 DIKI events extracted from OFFSIDES.
KidneyTox/diki_phenotype_tox21-rt-viability-hek293-p1_association.tsv contains computed association odds ratio between Tox21 HEK293 Cell viability phenotype and 24 DIKI phenotypes extracted from OFFSIDES.

LINCS/ contains the processed mapping files between active compounds of Tox21 assays and cell line-matched LINCS instances under 6 different dosage-time combinations: