The Multichannel Igor Electrophysiology Suite (MIES) is a proven sweep based data acquisition software package for intracellular electrophysiology (patch clamp) [1, 2, 3, 4, 5, 6]. It offers top of its class flexibility and robustness for stimulus generation, data acquisition, and analysis.
- Run up to five DACs in parallel for scalable data acquisition.
- Acquire data on up to eight headstage on a single DAC to probe up to 56 connections at once.
- Create arbitrarily complex stimulus sets with an intuitive GUI.
- Export all data, including all of its metadata, into the industry-standard NWBv2-format and read it back in
- Run custom code during data acquisition for Automatic Experiment Control and real-time adaptability.
- Automate experimental setup using configuration files for streamlined workflows.
- Interact with MIES from other programming languages (Python, C++, Javascript, ...) through ZeroMQ.
- Track and manage your experiments with comprehensive metadata acquisition and browsing tools.
- Leverage the integrated scripting language for flexible, on-the-fly electrophysiology data evaluation.
- Ensure compatibility with every earlier version of MIES, protecting your previous work and workflows.
- Download the latest release
- Windows: Run the installer
- MacOSX (analysis only): Manual installation
- View the documentation
Video tutorial of the postsynaptic potential/postsynaptic current data (PSX) analysis module
- Windows 10 64-bit or MacOSX 10.10
- Windows 10 64-bit
- NIDAQ MX XOP
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Digital to analog converters (DAC):
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National Instruments:
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Instrutech/HEKA ITC:
ITC devices are at the End-Of-Service-Life (EOSL). National Instruments DACs are recommended for MIES users looking for new hardware.
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Amplifier: Molecular Devices 700B
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Pressure control (optional):
- QPV High Resolution Pressure Regulator from Proportion-Air, Inc.; Part name: QPV regulator (custom, see part No), -10 psi to +10 psi; Part no.: QPV1TBNEEN10P10PSGAXLDD
- controlled through ITC 18/1600 or National Instruments USB 6001
The last released version receives fixes for all critical bugs.