If you are a newcomer to apply the the Deep Learning in bioinformatics area, the first question you may have is "What is the profile of deep learning in bioinformatics at present?"
Here is a reading roadmap of papers applying Deep Learning in bioinformatics!
Those papers are mainly published in Nature, Nature Methods, Nature protocols, NAR, Briefings in Bioinformatics, Bioinformatics, Drug Discovery Today, Genome Research, Genome Biology, PLoS computational biology, JCIM, JPR, Distill Pub, CACM, JACM, JMLR, and NIPS.
The recently added journals are AC, Nature Chemistry, Nature Reviews Chemistry, and Nature structural & molecular biology.
I would continue adding papers to this roadmap.
[0] Zhifei Zhang. "pDeep: Predicting MS/MS Spectra of Peptides with Deep Learning." AC. (November 10, 2017).
[0] Naohiro Kobayashi. "Noise peak filtering in multi-dimensional NMR spectra using convolutional neural networks." Bioinformatics. (09 July 2018).
[1] Ming Li. "De novo peptide sequencing by deep learning." PNAS. (July 18, 2017).
[0] SKARYSZ, A. ... et al, . "Convolutional neural networks for automated targeted analysis of raw gas chromatography–mass spectrometry data." IJCNN 2018. (2018).
[0] Hongmei Lu. "Deep-Learning-Based Drug–Target Interaction Prediction." JPR. (March 6, 2017)
[1] Jianyang Zeng. "NeoDTI: Neural integration of neighbor information from a heterogeneous network for discovering new drug-target interactions." Bioinformatics. (02 July 2018)
[0] Pierre Baldi. "Deep Learning in Biomedical Data Science." Annual Review of Biomedical Data Science. (2018).
[0] Yaoqi Zhou. "Accurate Prediction of Protein Contact Maps by Coupling Residual Two-Dimensional Bidirectional Long Short-Term Memory with Convolutional Neural Networks." Bioinformatics. (19 June 2018).
[1] Jinbo Xu. "ComplexContact: a web server for inter-protein contact prediction using deep learning." NAR. (22 May 2018).
[2] Jinbo Xu. "Protein threading using residue co-variation and deep learning." Bioinformatics. (1 July 2018).
[0] Jianzhu Ma. "Using deep learning to model the hierarchical structure and function of a cell." Nature Methods. (2018-04). (ps) ⭐⭐⭐⭐⭐
[0] Abdullah M Khamis. "DeFine: deep convolutional neural networks accurately quantify intensities of transcription factor-DNA binding and facilitate evaluation of functional non-coding variants." NAR. (02 April 2018). (ps) ⭐⭐⭐⭐⭐
[0] Sungroh Yoon. "lncRNAnet: Long Non-coding RNA Identification using Deep Learning." Bioinformatics. (29 May 2018).
[1] Huaiqiu Zhu. "LncADeep: An ab initio lncRNA identification and functional annotation tool based on deep learning." Bioinformatics. (29 May 2018).
[0] Tianwei Yu. "A graph-embedded deep feedforward network for disease outcome classification and feature selection using gene expression data." Bioinformatics. (29 May 2018).
[1] Wesley De Neve. "SpliceRover: Interpretable Convolutional Neural: Networks for Improved Splice Site Prediction." Bioinformatics. (21 June 2018).
[2] David A Hendrix. "A deep recurrent neural network discovers complex biological rules to decipher RNA protein-coding potential." NAR. (09 July 2018)
[0] LuZhang, JianjunTan, DanHan, HaoZhu. "From machine learning to deep learning: progress in machine intelligence for rational drug discovery." Drug Discovery Today.
[1] Dapeng Xiong, Jianyang Zeng, and Haipeng Gong. "A deep learning framework for improving long-range residue–residue contact prediction using a hierarchical strategy." Bioinformatics.
[2] Yeeleng S. Vang, Xiaohui Xie. "HLA class I binding prediction via convolutional neural networks." Bioinformatics.
[3] Baoji He, S. M. Mortuza, Yanting Wang, Hong-Bin Shen, Yang Zhang."NeBcon: protein contact map prediction using neural network training coupled with naïve Bayes classifiers." Bioinformatics.
[4] Nansu Zong, Hyeoneui Kim, Victoria Ngo, Olivier Harismendy. "Deep mining heterogeneous networks of biomedical linked data to predict novel drug–target associations." Bioinformatics.
[5] José Juan Almagro Armenteros et al. "DeepLoc: Prediction of protein subcellular localization using deep learning." Bioinformatics.
[6] Bite Yang et al. "BiRen: predicting enhancers with a deep-learning-based model using the DNA sequence alone." Bioinformatics.
[7] William J. Godinez et al. "A multi-scale convolutional neural network for phenotyping high-content cellular images." Bioinformatics.
[8] Xiuquan Du, Yanping Zhang et al. "DeepPPI: Boosting Prediction of Protein–Protein Interactions with Deep Neural Networks." JCIM.
[9] Moritz Hess et al. "Partitioned learning of deep Boltzmann machines for SNP data." Bioinformatics.
[10] Travers Ching et al. "Opportunities and obstacles for deep learning in biology and medicine." bioRxiv.
[11] A Esteva et al. "Dermatologist-level classification of skin cancer with deep neural networks." Nature. (FEB 2 2017).
[12] Seonwoo Min et al. "Deep learning in bioinformatics." Briefings in bioinformatics. (16 June 2016).