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sorghum_T2T

The codes to assemble two sorghum cultivars.

How to download genome files and gene structure annotation files?

Due to the strict restrictions on the gff3 file format by the National Genomics Data Center, I was unable to succeed despite my efforts, so I have hosted the data on Figshare. https://figshare.com/articles/dataset/Sorghum_genome/25764612

Regarding the BTx623 gff3 file, after our gene structure annotation pipeline, I utilized the collinearity among genomic sequences to add structural models of genes that we had not discovered but were annotated in BTx623-v3 and BTx623-v5 (completed by Liftoff), and subsequently, I performed two rounds of updates using PASA.

This version of the gff3 file includes more gene models than either BTx623-v3 or BTx623-v5. I will keep refining this annotation file and update it in a timely manner. I continue to see potential for optimization in this annotation, particularly concerning the length issues of UTRs, and I strongly suggest further validation with RNA-seq data before related analyses.

The gene names in BTx623-v3 and BTx623-v5 are identical; however, the gene names in the gff3 file I uploaded do not match those in the annotation files for versions v3/v5. To prevent this misunderstanding, I have deposited the relationship between the amino acid sequences of the BTx623-T2T transcripts and those of the longest transcripts of v3/v5 on figshare.

Should you wish to learn more about optimizing annotation details, or if any issues arise during use, feel free to contact me at weichuanzheng1202@163.com at any time.

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