Add support for MT inheritance models

[henrikstranneheim]

• Inherited maternally
• Transferred to all offspring
• Paternal MT DNA is not propagated to offspring
• All affected should carry variation

[moonso]

Ok so it is like AD, right?

[henrikstranneheim]

Yes, but the variant can only be inherited on the maternal side.

[moonso]

1. Mitochondria-linked Dominant (MD): Lika AD except
   • Only on MT
   • Mother affected and “1"
   • All offspring is affected and “1”
2. Mitochondria-linked (M):
   • Only on MT
   • Offspring can be either “0” or “1” i.e. reduced penetrance due to the bottleneck between generations (i.e. Mother to child transmission of MT subpopulation) or novel mutation in offspring
   • Mother unaffected and “0” or affected and “1"
   • Affected offspring is “1”
   • Unaffected offspring is “0"