Dietary_methionine_restriction

Code and scripts for analyzing metabolomics datasets for mice and human subjects undergoing dietary methionine restriction (MR).

Description of folders

• Chemotherapy: MATLAB scripts for analyzing metabolomics data for the combinational treatment of MR and chemotherapy (5-FU).
• Methionine_metabolites: MATLAB scripts for extracting metabolites within certain distance from methionine (i.e. methionine-related metabolites) in the human genome-scale metabolic network Recon2
• PDX: MATLAB scripts for analyzing metabolomics data for the patient-derived xenograft models of CRC
• Plasma: MATLAB scripts for analyzing metabolomics data for the plasma samples from different models
• Sarcoma: MATLAB scripts for analyzing metabolomics data for the Sarcoma models
• Time_course: MATLAB scripts for the singular value decomposition (SVD) analysis of time-course data in plasma of mice eating control/MR diets

Usage

The scripts were written and tested in MATLAB R2018b. To run the scripts, add heatmap.m to the MATLAB search path, then execute the .m file in the corresponding folder.

License

This software is released under the MIT License.