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jwildfire edited this page Dec 5, 2021 · 3 revisions

Graphic List

Released

In Development - Additional graphics are currently being developed or tested for use with safetyGraphics:

Idea List - Finally, we're always looking for new types of interesting visualizations to develop. We've discussed adding the following:

  • Forestly - https://elong0527.github.io/forestly/articles/example.html
  • Web Codebook - https://github.com/RhoInc/web-codebook
  • Add charts from clinDataReview pacakge (e.g. treemap) - vignette with examples is here
  • Nephrotoxicity Domain
    • Identify subjects with serum creatinine values exceeding ULN (plots of SCr over time).
    • Identify subjects with elevations of serum creatinine >2x baseline, even if the values remain within the normal range.
    • Identify subjects with estimated glomerular filtration rate (eGFR) below a threshold value. Calculate eGFR based on serum creatinine and cystatin C. Display changes over time and compare relative changes in eGFR by creatinine and by cystatin C as an indicator of possible renal transporter inhibition.
    • Display changes in BUN over time with Scr and/or eGFR as an indicator of pre-renal azotemia.
    • Display study drug and concomitant medication administration, an appearance of AEs, relative to renal lab changes.
  • QTc Prolongation Domain: Based on the CTSPedia QTc graphic, allow the ability to select a point to drill down to subject details, such as:
    • Changes in QTc (by Fridericia, Bazett, Nomogram, Framingham, Hodges) over time.
    • Display of heart rate relative to QTc (to identify instances when the HR is <60).
    • Display PK data (as available) relative to QTc changes.
  • AE Domain
    • Tendril Plot
    • Analysis of Recurrent AEs
    • AE clustering by time
  • Anaphylaxis
  • Injection site reactions
  • Hypersensitivity
  • AE clustering by time
  • Vital signs
  • Bleeding
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