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The analysis below identifies a number of miRNA and miRNA clusters (e.g. let-7a/let-7b/miR-4763) that are predicted to target different regions of SARS-CoV-2. Further work is needed to validate experimentally if the activation of these miRNA can prevent or slow down the replication of the SARS-CoV-2 virus and help with the COVID-19 pandemic. Of note is that let-7b was previously (https://pubmed.ncbi.nlm.nih.gov/22391672/) shown to be a regulator of Hep C virus replication.
Above is only a summary, view the full blog post at https://cm.jefferson.edu/coronavirus-targets/
These code notebooks are made available under the open source GNU GPL v3.0 license (https://www.gnu.org/licenses/gpl-3.0.en.html).