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MNI Average Brain (305 MRI) Stereotaxic Registration Model This is a version of the MNI Average Brain (an average of 305 T1-weighted MRI scans, linearly transformed to Talairach space) specially adapted for use with the MNI Linear Registration Package (mni_reg). Included in this package are the following files: average_305.mnc a version of the average MRI that covers the whole brain (unlike the original Talairach atlas), sampled with 1mm cubic voxels average_305_mask.mnc a mask of the brain in average_305.mnc, semi-automatically created by Dr. Colin Holmes <colin@pet.mni.mcgill.ca>. Note that this mask has had holes filled in, so it is a connected volume but includes non-brain tissue (eg. the CSF in the ventricles) average_305_headmask.mnc another mask, required for nonlinear mode Here's a brief summary of what you need to do: 1) Build and install the entire MNI AutoReg package, as described in the README with that package. 2) Install the model: * ./configure --prefix=/usr/local/mni or where you installed mni_autoreg * make * make install Now, you're ready to try out mritotal on real data. See the file TESTING included with MNI AutoReg for instructions on doing this. Any problems with this package should be reported to Andrew Janke <a.janke@gmail.com>, or Louis Collins <louis@bic.mni.mcgill.ca>. Reference: Collins, D.L., Neelin, P., Peters, T.M., Evans, A.C. (1994) Automatic 3-D intersubject registration of MR volumetric data in standardized Talairach space. J. Comput. Assist. Tomogr. 18 (2), 192–205. Evans, A.C., Collins, D.L., Milner, B. (1992) An MRI-based stereotaxic atlas from 250 young normal subjects. Proc 22nd Annual Symposium, Society for Neuroscience, 18, p. 408. Evans, A.C., Marrett, S., Neelin, P., Collins, D.L., Worsley, K., Dai, W., Milot, S., Meyer, E., Bub, D. (1992) Anatomical mapping of functional activation in stereotactic coordinate space. NeuroImage 1 (1), 43–63. Evans, A.C., Collins, D.L., Mills, S.R., Brown, E.D., Kelly, R.L., Peters, T.M. (1993) 3D statis- tical neuroanatomical models from 305 MRI volumes. Proc IEEE-Nuclear Science Symposium and Medical Imaging Conference, pp. 1813–1817.
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