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How SAMap deal with species-specific cell types/clusters in integration? #151

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DiracZhu1998 opened this issue Jul 9, 2024 · 0 comments

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@DiracZhu1998
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Dear Dr. Atarashansky,

I tried your wonderful tool with a dataset containing species-specific cell types, but the species-specific cell type can still map to another species' cell type with a mapping score above 0.5. Although the gene pairs supporting this only have around 100 gene pairs. If I understand your paper correctly, your method will force the species-specific cell types to map to a similar (but not homologous) cell type with much more weight on the small number of genes in the gene homology graph.

Could you confirm that?

Best wishes,
YZ

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