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Adapting GenePairFinder to identify gene pairs with divergent expression in a pair of clusters? #154

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laracbusby opened this issue Oct 15, 2024 · 0 comments

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@laracbusby
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Hi,

Thanks for such an awesome tool to integrate across species datasets!

I am curious whether there would be a way to adapt the GenePairFinder function to identify gene pairs that are 1) expressed differentially between a pair of clusters (1 from each species) and 2) contribute negatively to the correlation score between that pair of clusters.

I am interested in identifying genes that are expressed in one species but not the other in a specific pair of clusters - i.e., what are the gene level differences which contribute most significantly toward the lowering of a correlation value between two clusters?

Thanks so much!

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