Created new class GeneAffectsChemicalAssociation with qualifiers

[RichardBruskiewich]

Resolves issue #1387.

@sierra-moxon, note that I added a rather atypical examples: tag value into the model. I don't know if this may be problematic - I don't see any other comparable examples in the file.

reference for the example:
https://ctdbase.org/detail.go?type=reference&acc=11042129

[sierra-moxon]

Is the underlying assumption of the example in this PR, that we are talking about a variant of TRPC4 that affects the chemical?

Is this added as the "inverse" of chemical affects gene association? (if so, the predicate here should be affected by -- eg. gene affected_by chemical).

[RichardBruskiewich]

Is the underlying assumption of the example in this PR, that we are talking about a variant of TRPC4 that affects the chemical?

Is this added as the "inverse" of chemical affects gene association? (if so, the predicate here should be affected by -- eg. gene affected_by chemical).

Hi @sierra-moxon, I think I commented a bit to you over slack, but again, here's what I know... The example edge given to me by Sandrine is:

        subject: TRPC4  # biolink:Gene
        predicate: affects
        object: Barium    # biolink:SmallMolecule
        object_aspect_qualifier: transport
        object_direction_qualifier: increased

It is a very good question to ask what the exact biochemical activity is of TRPC4: gene expression? variant affect? TRPC4 gene product directly interacting with the barium channel protein? all of the above?